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All Journal Folia Medica Indonesiana Journal of Social Research
Shanti, Bayu Dharma
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Humanities Computer Science & IT Economics, Econometrics & Finance Education Social Sciences Other

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Effectivity of Erythropoietin Alpha Compared to Erythropoietin Beta in Patients with Chronic Kidney Disease-Anemia on Hemodialysis Prasetya, Anak Agung Ngurah Putra Riana; Suprapti, Budi; Shanti, Bayu Dharma
Folia Medica Indonesiana Vol. 55 No. 2 (2019): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.652 KB) | DOI: 10.20473/fmi.v55i2.24461

Abstract

Anemia in patient with chronic kidney disease could cause a lot of complication. The first line therapy of this condition is by treating with erythropoiesis-stimulating agents (ESA) or called erythropoietin. The erythropoietin alpha and beta were two types of the human recombinant erythropoietin that are usually used in Indonesia. The aim of this study was to determine the effectivity of erythropoietin alpha compared to erythropoietin beta especially in haemoglobin and haematocrit level. This prospective observational study was conducted in March – September 2016. The inclusion criteria were CKD stage 5 patients with a minimum of 3 months of regular hemodialysis, Hb <10 g/dL with enough iron status ST > 20% and FS > 200ng/mL. The methology of this study had been approved by the Health Research Ethics Committee of the Bhayangkara H.S. Samsoeri Mertojoso Hospital, Surabaya. Patients received 2000 IU subcutaneous erythropoietin twice a week on both groups. Blood sample was withdrawn in pre-treatment and after 4 weeks of post erythropoietin therapy treatment for measurement of haemoglobin and haematocrit. Target for this erythropoietin therapy are increase of Hb 0.5 – 1.5 g/dL (not to exceed 12 g/dL) and increase of Hct level 2 – 4 % in 4 weeks. Based on the inclusion criteria, there were 20 patients in this study (10 patient each of both erythropoietin alpha either beta group) that consist of 7 women and 13 men. After the treatment, the mean of increased haemoglobin level for erythropoietin alpha group was 1.28 ± 0.80 g/dL (p=0.001) and erythropoietin beta was 0.37 ± 0.95 g/dL (p=0.254). The mean of increased haematocrit level for erytropoietin alpha group was 3.56 ± 3.46 % (p=0.010) and erythropoietin beta was 1.34 ± 2.71 % (p=0.152). In comparison of haemoglobin and haematocrit achievement in both groups showed that erythropoietin alpha gave better achievement in haemoglobin parameter (p=0.033), but there were no differences in both groups on haematocrit parameters (p=0.127).
A Comparison of The Incidence of Coronary Heart Disease In Police Based In Urban And Rural Areas: A Study of East Java Regional Police Rakhmawati, Iwana Anny; Khrisna, Bagus Putra Dharma; Shanti, Bayu Dharma; Valentine, Vammy Baverly; Fadila, Alvin
Journal of Social Research Vol. 4 No. 1 (2024): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i1.2356

Abstract

Coronary heart disease (CHD) poses significant risks to health, especially among police officers, a high-risk occupational group due to their demanding work conditions. Factors such as high workloads, occupational stress, poor eating habits, lack of exercise, shift work, and sleep disturbances contribute to CHD risks. This study examined differences in CHD prevalence and risk factors between urban and rural police officers in East Java as part of an evaluation for preventive strategies. A cross-sectional study involving 766 police officers (383 urban, 383 rural) was conducted during 2024 medical check-ups at Bhayangkara State Police Hospital Surabaya. Data collection included physical exams, ECG, treadmill tests, and laboratory analyses of cholesterol and fasting blood sugar. CHD was identified through ischemic ECG changes, treadmill test symptoms, or medical history of cardiac events. Results showed CHD prevalence significantly higher among urban officers (89.7%) compared to rural counterparts (10.3%) (p=0.000). Total cholesterol was significantly associated with CHD risk (p=0.003). These findings highlight the greater vulnerability of urban police officers to CHD, emphasizing the need for proactive prevention strategies. Regular clinical and echocardiographic follow-ups, combined with lifestyle modifications and treatment, are critical to mitigating CHD risks and improving health outcomes for police officers in both urban and rural settings.
Co-Authors Budi Suprapti Fadila, Alvin Khrisna, Bagus Putra Dharma Prasetya, Anak Agung Ngurah Putra Riana Rakhmawati, Iwana Anny Valentine, Vammy Baverly