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All Journal Althea Medical Journal Cermin Dunia Kedokteran
Jones, Frenky
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Health Professions Medicine & Pharmacology Public Health

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Akurasi Diagnostik Fibrosis Hati Berdasarkan Rasio Red Cell Distribution Width (RDW) dan Jumlah Trombosit dibandingkan Fibroscan pada Penderita Hepatitis B Kronik Jones, Frenky; Sembiring, Juwita; Zain, Lukman Hakim
Cermin Dunia Kedokteran Vol 43, No 9 (2016): Kardiovaskuler
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.765 KB) | DOI: 10.55175/cdk.v43i9.858

Abstract

Hepatitis B kronik merupakan masalah global dan Indonesia termasuk negara yang memiliki prevalensi hepatitis B yang tinggi. Keterbatasan tindakan biopsi hati untuk mendiagnosis fibrosis hati karena invasif, membangkitkan penelitian metode non-invasif. Dilakukan penelitian uji diagnostik potong lintang untuk mengetahui akurasi rasio RDW terhadap jumlah trombosit untuk memprediksi derajat fibrosis hati penderita hepatitis B kronik. Terhadap subjek penelitian dilakukan pemeriksaan HBsAg, darah rutin, dan fibroscan di RSUP H. Adam Malik, Medan, sejak Januari 2015 sampai Maret 2015. Nilai rasio RDW terhadap trombosit dihitung dari hasil pemeriksaan darah rutin. Derajat fibrosis hati dinilai berdasarkan hasil fibroscan dari skala F0-F4. Prosedur analisis adalah ROC dan AUC. Dari 34 kasus, 20 orang (58,8%) termasuk kelompok fibrosis hati ringan-sedang (F≤2) dan 14 orang (41,2%) kelompok fibrosis berat (F>2). Nilai akurasi sebesar 72,3 % (95% CI: 84,1% s/d 97%). Dengan nilai cut off 0,0591, didapatkan sensitivitas 71,4%, spesifisitas 60%, NPP 55,6%, NPN 75%, RKP 1,79, dan RKN 0,48. Simpulan: Rasio RDW terhadap jumlah trombosit mampu memprediksi derajat fibrosis hati penderita hepatitis B kronik dengan tingkat akurasi sedang (72,3%).Chronic hepatitis B is a global problem and Indonesia has a high prevalence of hepatitis B. Limitation of liver biopsy as an invasive method, initiates many studies on non invasive diagnosing method for liver fibrosis. The cross sectional study was conducted to determine the accuracy of RDW to Platelet Ratio (RPR) in predicting liver fibrosis degree in chronic hepatitis B. HBsAg, complete blood count, and fibroscan was examined in H. Adam Malik Hospital, Medan, from January - March, 2015. RPR was calculated. The degree of liver fibrosis assessed by fibroscan on a scale of F0-F4. The accuracy was evaluated by constructing ROC and the AUC. From 34 cases, 20 subjects (58,8%) in mild-moderate liver fibrosis (F≤2) and 14 subjects (41,2%) in severe liver fibrosis (F>2). The accuracy is 72,3 % (95% CI : 84,1% - 97 %) with a cut off value 0,0591. Sensitivity 71,4%, specificity 60%, PPV 55,6%, NPV 75%, PPR is 1,79, and NPR is 0,48. Conclusion: RDW to platelet ratio can predict liver fibrosis grade in chronic hepatitis B with a moderate degree of accuracy (72,3%).
Difference of Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio, and Platelet-to-Lymphocyte Ratio in Patients with Non-Hodgkin and Hodgkin Lymphoma Jones, Frenky; Mersiana, Lusi; Oehadian, Amaylia; Marthoenis, Marthoenis
Althea Medical Journal Vol 11, No 4 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n4.3335

Abstract

Background: Malignancy and inflammation are strongly connected. The inflammatory processes play a significant part in the development of lymphoma. Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) can be used as potential biomarkers of inflammation in lymphoma. This study aimed to discover the differences between NLR, MLR, and PLR in patients diagnosed with non-Hodgkin lymphoma (NHL), and Hodgkin lymphoma (HL). Methods: This study employed a retrospective design using data from the lymphoma registry at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia from 2020 to 2023. Sampling was carried out consecutively. Hematological data of patients with NHL and HL before chemotherapy were collected. The variance between the two groups was examined utilizing the Mann-Whitney U test.Results: In total, 122 data of patients were included, consisting of 75% NHL patients and 25% HL patients with a median age of 54 years (IQR 43–62). The overall NLR, MLR, and PLR tended to be lower in nHL than in HL patients although the differences were not statistically significant; with NLR 2.7 (0.7 – 12.2) vs. 3.2 (1.1 – 10.8)  p=0.287, MLR 0.36 (0.04 – 1.86) vs. 0.46 (0.09 – 1.78) p=0.150, and PLR was 160.6 (20.2 – 1533.3) vs. 211.2 (50.6–1156.3) p=0.189, for NHL and HL, respectively.Conclusion: The lower values of NLR, MLR, and PLR in NHL indicate lower systemic inflammatory status in NHL than HL patients. Further studies are needed to evaluate dynamic changes of these biomarkers during treatment.
Co-Authors Amaylia Oehadian Juwita Sembiring Lukman Hakim Zain M. Marthoenis Mersiana, Lusi