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All Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Cermin Dunia Kedokteran
Taufiqurrohman, Agus
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Health Professions Medicine & Pharmacology Public Health

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Epilepsi Terkait Tumor Otak Pada Suspek Tumor Sinonasal Dengan Infiltrasi Serebral: Sebuah Laporan Kasus Darumurti, Rissito Centricia; Setyana, Michael Kevin Robby; Khairani, Atitya Fithri; Taufiqurrohman, Agus
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 1 No. 2 (2023)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

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Abstract

Epilepsi adalah gangguan otak yang ditandai dengan kecenderungan terjadinya kejang atau bangkitan epileptik. Epilepsi yang ditimbulkan oleh tumor otak disebut epilepsi terkait tumor otak. Patofisiologi yang mendasarinya masih belum banyak dipahami tetapi telah terbukti bersifat multifaktorial. Tujuan penulisan artikel ini adalah untuk melaporkan kasus dari seorang pasien perempuan berusia 50 tahun datang dengan keluhan utama kejang disertai benjolan di mata kanan yang terus membesar selama 6 bulan terakhir. Pemeriksaan fisik menunjukkan proptosis, gangguan visus dan papilatrofi pada mata kanan, paresis nervus kranialis III, IV, dan VI dekstra, lesi nervus kranialis V sensoris cabang I dan II dekstra, refleks primitif glabela positif, dan gangguan kognitif berat dengan ketergantungan ringan-sedang. Hasil radiologi menunjukkan suspek tumor sinonasal dekstra dengan infitrasi serebral. Hasil elektroensefalografi menunjukkan gambaran abnormal dengan frontal bilateral epileptiform discharges (L>R) disertai focal slowing regio frontalis dan frontal intermittent rhythmic delta activity (FIRDA) yang konsisten dengan klinis focal seizures disorder dapat sesuai dengan epilepsi lobus frontalis. Pasien mendapatkan terapi steroid deksametason intravena, fenitoin, asam valproat, asam folat, kalium aspartat, dan haloperidol. Pasien dipulangkan setelah perawatan hari kesepuluh dalam kondisi bebas kejang selama tujuh hari. Kondisi tumor pada kasus telah mencapai stadium lanjut, sebagaimana ditunjukkan oleh invasi tumor ke struktur tulang di sekitarnya dan struktur intrakranial sehingga memicu terjadinya epilepsi. Epilepsi dapat terkontrol dengan terapi steroid intravena serta obat anti epilepsi kombinasi.  KATA KUNCI: epilepsi; tumor otak; tumor sinonasal.
Manajemen Epilepsi pada Kehamilan Taufiqurrohman, Agus; Nuradyo, Damodoro; Harsono, Harsono
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol1, No 1, (2009)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

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Epilepsy is recognized as the commonest serious neurological disorder in the world. Women with epilepsy  experience several gender-related physical and social problems. They constitute high obstetric risk because of reduced fertility, risk of seizures during pregnancy, and complications of pregnancy. Hormonal and other factors can alter the pharmacokinetics of antiepileptic drugs during pregnancy and puerperium. Antenatal exposure to antiepileptic drugs, particularly at higher dosage and in polytherapy, increases the risk of fetal malformation. Recent reports raise the possibility of selective developmental language deficits and neurocognitive deficits with antenatal exposure to antiepileptic drugs. There are concerns regarding the effect of traces of antiepileptic drugs that pass to the infant during breast-feeding. The pre conception management is the cornerstone for epilepsy care in Women with epilepsy. A careful reappraisal of each case should ascertain the diagnosis, the need for continued antiepileptic drugs therapy, selection of appropriate antiepileptic drugs, optimization of the dosage, and prescription of folic acid. During pregnancy, the fetal status needs to be monitored with estimation of serum a-feto-protein and ultrasound screening for malformations. The dosage of antiepileptic drugs can be adjusted according to clinical requirement and blood levels of antiepileptic drugs. Several institutions recommend oral vitamin K toward the end of pregnancy when enzymeinducing.Key Words : epilepsy, pregnancy, management, complication
Spastic Paraplegia Secondary to Spinal Metastasis in a Patient with Advanced-Stage Breast Cancer: A Case Report: Case Report Luvita Sari, Fery; Taufiqurrohman, Agus
Cermin Dunia Kedokteran Vol 53 No 10 (2026): Oktober 2026 - CDK 357
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v53i10.2014

Abstract

Introduction: Spinal metastasis in breast cancer patients can lead to severe pain, neurological deficits, and significant morbidity, impacting quality of life and chances of survival in breast cancer patients. Case: A 48-year-old woman was referred to a neurologist because of lower extremity weakness. Due to spinal cord compression, she had paraplegia with chronic progressive mixed-type lower back pain, with radiating to the pelvis, accompanied by numbness, tingling, and burning from both feet to the subumbilical region, and impairment of defecation and urination. She had a history of breast cancer with chemotherapy and radiotherapy. Her numeric rating scale score was 7, ID pain score was 4, Karnofsky score was 40; neurological examination revealed spastic paraplegia, segmental hypoesthesia at and below the 11th spinal cord level, and urinary and bowel retention. Radiologic examination showed kyphosis with osteolytic and osteosclerotic thoracic vertebrae. Bone survey showed bone metastases in thoracic vertebral bodies 5–12, the right ilium, and the right proximal femur. Discussion: The patient was diagnosed with spinal metastasis based on physical examination and supporting investigations, but further follow-up was limited. Early recognition of the clinical condition is expected to help prevent further deterioration of neurological deficits. Conclusion: The patient was diagnosed with spinal metastasis from breast cancer and received analgesic and corticosteroid therapy. The prognosis was poor.
Co-Authors Harsono Harsono Khairani, Atitya Fithri Luvita Sari, Fery Nuradyo, Damodoro Rissito Centricia Darumurti Setyana, Michael Kevin Robby