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All Journal Jurnal SOLMA Indigenous Biologi
Dian Fita Lestari
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Agriculture, Biological Sciences & Forestry Other

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Pemeriksaan Golongan Darah dan Rhesus Pada Siswa Kelas X SMA Negeri 11 Bengkulu Utara Dian Fita Lestari; Fatimatuzzahra Fatimatuzzahra; Jarulis Jarulis
Jurnal SOLMA Vol. 9 No. 2 (2020)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v9i2.5346

Abstract

Abstract Blood type is hereditary and very important to know because it is associated with the success of blood transfusions, organ transplants, and hereditary diseases. In the blood type system that is often used is the ABO system, based on the presence of antigens A and B which are on the surface of red blood cells. And the rhesus blood group system is the second largest after the ABO system, which is determined based on the presence of antigen D. Because of the importance of knowing blood type and rhesus, it is necessary to have a blood type and rhesus examination of class X students in SMA Negeri 11 Bengkulu Utara. The method used in this dedication activity includes the preparation of materials used for the examination of blood groups and the execution of activities so that the results of each student's blood type are obtained. Blood type examination was attended by 34 students, 13 male and 21 female. Based on the results of the examination, the percentage of students who had blood type A was 29.4%, blood type B was 29.4%, blood type O was 29.4%, and AB blood type was at least 11.8%. The rhesus examination results, show that all students have positive rhesus (Rh +).
Pengaruh Induksi Allopurinol terhadap Gambaran Histopatologi Ginjal Mencit Jantan (Mus musculus) Strain DDY Dian Fita Lestari
Indigenous Biologi : Jurnal Pendidikan dan Sains Biologi Vol 5 No 1 (2022): Indigenous Biologi
Publisher : Prodi Pendidikan Biologi FKIP Universitas Kristen Artha Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33323/indigenous.v5i1.290

Abstract

Asam urat dalam tubuh disintesis dalam hepar dan mengalir melalui darah menuju ginjal. Jumlah asam urat yang berlebih dapat mempengaruhi kinerja fungsi ginjal terutama pada fungsi filtrasi renal, absorbsi dan sekresi. Penggunaan obat allopurinol banyak digunakan masyarakat dalam menurunkan kadar asam urat darah. Tujuan dari penelitian ini untuk mengetahui efek induksi allopurinol terhadap gambaran histologi ginjal mencit jantan (Mus musculus) strain DDY. Metode dalam penelitian ini adalah rancangan acak lengkap dibagi menjadi 4 kelompok masing-masing 4 ekor mencit. Kelompok kontrol (K0) diberi Na-CMC 0,5%, kelompok I, II, III masing-masing diinduksi allopurinol 10 mg/kgBB, 20 mg/kgBB, dan 30 mg/kgBB selama 14 hari. Induksi allopurinol dilakukan dengan cara sonde oral. Berdasarkan hasil penelitian menunjukkan bahwa terdapat kerusakan struktur ginjal berupa pembengkakan sel, nekrosis, hemoragi, kongesti, dilatasi sinusoid, degenerasi hidropis dan infiltrasi leukosit. Semakin tinggi induksi dosis allopurinol yang diberikan pada mencit, maka kerusakan ginjal juga semakin parah. Hal ini menunjukkkan bahwa allopurinol sebagai obat penurun asam urat memiliki efek nefrotoksik.
Co-Authors Fatimatuzzahra Fatimatuzzahra Jarulis Jarulis