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All Journal Bioma : Jurnal Biologi Indonesia Cermin Dunia Kedokteran

Sutiono, Dias Rima

Unknown Affiliation

Author-ID : 1817029

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Articles

Significance of Lewy Body Formation in Development of Parkinsonâ€™s Disease Sahay, Shivanki; Sutiono, Dias Rima
Cermin Dunia Kedokteran Vol 45, No 8 (2018): Alopesia
Publisher : PT. Kalbe Farma Tbk.

Parkinsonâ€™s disease is a serious neurodegenerative disease characterized by depletion of neurons in the substantia nigra of the basal ganglia. These dying out neurons are found to contain traces of Lewy bodies, an abnormal protein filament of alpha-synuclein and that otherwise play an important role in the nervous system, especially at synapses.Penyakit Parkinson merupakan penyakit neurodegeneratif serius ditandai dengan deplesi neuron di substansia nigra ganglia basalis.Neuron ditemukan mengandung jejak Lewy Bodies, yang merupakan filamen protein abnormal alpha-synuclein.Â

Hutchinson Gilford Progeria Syndrome (HGPS): Potential Treatments Sutiono, Dias Rima; Adeline, Fransiska
Cermin Dunia Kedokteran Vol 45, No 9 (2018): Infeksi
Publisher : PT. Kalbe Farma Tbk.

The Hutchinson-Gilford Progeria syndrome is a rare genetic disease that causes an early accelerated aging in children; clinically characterized by manifestations affecting skin, musculoskeletal system and blood vessels, also other features supporting aging processes. This disease affects 1 in 4 - 8 million newborn all over the world without any race and gender preferences. The clinical features of HGPS usually appear in the age of two and will be discovered through clinical diagnosis. It then will be followed by health problems like coronary atherosclerosis that can be life-threatening. The life-span is usually 14,6 years. This review will discuss some emerging potential treatment such as FTI (Farnesyltransferase inhibitors).Sindrom Hutchinson-Gilford Progeria adalah penyakit genetik langka berupa penuaan lebih cepat pada usia anak-anak ditandai beberapa manifestasi di antaranya kulit, sistem muskuloskeletal dan pembuluh darah, serta hal lain sesuai proses penuaan. Penyakit ini terjadi pada 1 di antara 4-8 juta bayi baru lahir di seluruh dunia tanpa preferensi ras dan gender. Gambaran klinis HGPS biasanya muncul di usia dua tahun, diikuti masalah kesehatan seperti aterosklerosis koroner yang dapat mengancam jiwa. Rentang hidup biasanya 14,6 tahun. Ulasan ini mengenai beberapa pengobatan potensial seperti FTI (inhibitor Farnesyltransferase).

Acne and Food Relation: A Naturopathic Perspective Sutiono, Dias Rima; Malika, Ibdati; -, Samirah; Almira, Nadita Putri; Lestari, Sheila
Cermin Dunia Kedokteran Vol 44, No 6 (2017): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Acne is a result of internal imbalance which appears in the form of inflammation, caused by the accummulation of oil, dirt and bacteria under the skin. Acne is the most prevalent skin disease and occurs in all ages, with the highest prevalence in adolescence. Naturopathy is the term for using prevention methods, based on the roots of the disease. This article is to review several scientific evidences on the association between acne and food. Thus, might support naturopathic perspective in acne prevention.Jerawat merupakan hasil ketidakseimbangan internal tubuh yang timbul dalam bentuk peradangan disebabkan oleh tumpukan minyak, kotoran, dan bakteri di bawah kulit. Jerawat merupakan penyakit kulit yang paling umum dan dapat menyerang segala usia,terutama remaja. Naturopati adalah istilah untuk penggunaan metode pencegahan penyakit berdasarkan akar penyebab. Artikel ini akan meninjau beberapa bukti ilmiah hubungan antara jerawat dan makanan. Hal ini dapat mendukung perspektif naturopati untuk mencegah jerawat.

Primary Amebic Meningoenciphalitis (PAM) Sutiono, Dias Rima; Aisyah, Siti
Cermin Dunia Kedokteran Vol 44, No 12 (2017): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Naegleria fowleri is one of free-living amoeba that can be found around the world. It is also known as the causative agent of Primary Amebic Meningoencephalitis (PAM). PAM is a rare Central Nervous System (CNS) infection and can lead to fatal outcome. Since the first discovery, it becomes the problem worldwide. Misdiagnoses are common in PAM patient. The causative agent of PAM is living in the warm freshwater. Thus, the occurrence of this infection is high in summer and warmest season through the year. Due to its living characteristics, this amoeba has the potential to live in the Indonesia waters. The purpose of this review is to describe the difference between PAM and bacterial meningitis, epidemiology, diagnosis and prevention of PAM.Naegleria fowleri adalah salah satu amuba yang hidup bebas dan dapat ditemukan di seluruh dunia. N. fowleri dikenal sebagai agen penyebab Primary Amebic Meningoencephalitis (PAM). PAM merupakan infeksi langka yang menyerang sistem saraf pusat (SSP) dan dapat fatal. Sejak ditemukan telah menjadi masalah global. PAM sering salah didiagnosis. Agen penyebab PAM hidup di air tawar hangat; kejadian infeksi tertinggi saat cuaca terpanas. Karakteristik tersebut sesuai dengan iklim di Indonesia. Kajian ini diharapkan mampu menggambarkan perbedaan antara PAM dan meningitis yang disebabkan bakteri, epidemiologi, diagnosis dan pencegahan PAM.

Dengue, Chikungunya, and Zika: Differences in Similarities Sutiono, Dias Rima; Gunawan, Jeremy David
Cermin Dunia Kedokteran Vol 44, No 3 (2017): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Arbovirus (arthropod-borne virus) outbreaks have become a major problem in recent decades. Dengue, Chikungunya, and Zika outbreaks are part of the main focus currently as they share similar vector, symptoms, and environment. Reported cases of these viruses have occurred in epidemic areas with low mortality rate at the same time. This condition complicates diagnosis. Despite those similarities, each virus has their unique viral characteristics, transmission, symptoms, and complications. These unique characteristics can improve understanding of the diseases and be used to prevent and to diagnose the disease.Arbovirus (virus arthropoda-borne) merupakan wabah yang menjadi masalah besar dalam beberapa dekade terakhir. Wabah Dengue, Chikungunya, dan Zika termasuk fokus utama saat ini, karena memiliki vektor, gejala, dan lingkungan yang sama. Kasus di daerah epidemi dengan angka kematian rendah dilaporkan pada saat yang sama, kondisi ini mempersulit diagnosis penyakit. Meskipun mempunyai kesamaan, masing-masing virus memiliki karakteristik, transmisi, gejala, dan komplikasi yang unik. Karakteristik tersebut dapat digunakan untuk diagnosis, serta dapat meningkatkan pemahaman tentang penyakit dan cara-cara pencegahannya.

Triple Negative Breast Cancer (TNBC): Possible Biomarkers and Treatments Sutiono, Dias Rima; Shalannandia, Widad Aghnia
Cermin Dunia Kedokteran Vol 44, No 2 (2017): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Triple negative breast cancer (TNBC) is one of the breast cancer subtype, which account for around 15-20% of overall breast cancer cases. Women with Hispanic or African-American descent are having higher risk factor to develop this type of breast cancer, especially \in their premenopausal period (under 40). This highly aggressive and poor prognosis type of breast cancer does not have several molecular receptors (estrogen receptor, progesterone receptor, and HER2 receptor). The absence of those receptors leads to its insensitivity to hormonal therapies, resulting in limited choice of therapy. Numerous studies have been conducted to discover other potential therapies. The clinical characteristic and other information regarding triple negative breast cancer will be discussed along with several potential prognostic biomarkers and treatments for this cancer.Triple negative breast cancer (TNBC) merupakan salah satu subtipe kanker payudara, yang mencapai 15-20 % kasus kanker payudara secara keseluruhan. Wanita keturunan Hispanik atau Afrika - Amerika lebih berrisiko, terutama dalam periode premenopause (di bawah 40 tahun). Kanker jenis ini sangat agresif dan tidak memiliki beberapa reseptor molekul (reseptor estrogen, reseptor progesteron, dan reseptor HER2). Tidak adanya reseptor mengarah ke ketidakpekaan tumor untuk terapi hormonal, mengakibatkan pilihan terapi terbatas dibandingkan dengan jenis kanker payudara lainnya. Sejumlah penelitian telah dilakukan untuk menemukan terapi potensial lain. Karakteristik klinis dan informasi lain mengenai kanker payudara triple negatif akan dibahas bersama beberapa biomarker prognostik potensial dan pengobatan untuk kanker ini.

CURCUMIN FOR ALZHEIMERâ€™S DISEASE (AD) POTENTIAL TREATMENT: Literature Review Sutiono, Dias Rima; Iasmartua, Steven
Bioma Vol. 13 No. 2 (2017): Bioma
Publisher : LPPM Universitas Negeri Jakarta

Various studies had been conducted regarding the effect of curcumin on AD patients, thus, many of the studies had suggested that curcumin had the potential to prevent and treat AD through several molecular mechanisms including act as anti-inflammatory, anti-oxidant, binding the AÎ² plaques, metal chelation, and lowering cholesterol level. One of the prominent characteristics of this neurodegenerative disease is shown by the presence of beta amyloids plaques (AÎ²) and inflammation inside the patientâ€™s brains; and as mention above curcumin had shown its capabilities in inhibiting the AÎ² plaques and act as an anti-inflammation agent.

Co-Authors -, Samirah Adeline, Fransiska Almira, Nadita Putri Gunawan, Jeremy David Iasmartua, Steven Lestari, Sheila Malika, Ibdati Sahay, Shivanki Shalannandia, Widad Aghnia Siti Aisyah

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