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Sebayang, Loraetta Brety
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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Inovasi Pembuatan Teh Herbal dari Jantung Pisang dengan Tambahan Daun Stevia Sebagai Pemanis Alami Sinulingga, Siska Esperanza; Sebayang, Loraetta Brety; Sihotang, Samuel
JURNAL BIOS LOGOS Vol 11, No 2 (2021): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v11i2.35677

Abstract

(Article History: Received August 27, 2021; Revised Sept 17, 2021; Accepted Sept 26, 2021) ABSTRAKInovasi bahan dasar yang dapat dijadikan teh herbal adalah jantung pisang, karena memiliki metabolit sekunder berupa flavonoid, kumarin dan golongan fenolik. Penelitian ini bertujuan untuk membuat teh herbal jantung pisang dan mengetahui standar mutunya. Pembuatan teh herbal dilakukan dengan variasi suhu pengeringan 50°C; 90°C; 110°C dan waktu pengeringan 110; 130; 150 menit kemudian dilakukan uji standar mutu dan skrining serbuk teh herbal. Hasil uji persyaratan mutu teh herbal:  kadar air (7,1%; 6,8%; 2,3%), kadar ekstrak dalam air (5,96%; 8,6%; 5 0,76%), kadar abu total (7,4%; 6,2%; 3,9%), kadar abu larut air (4,62%; 7,88%; 10,09%), kadar abu tidak larut asam (0,93%; 0,7%; 0,47%), kandungan flavonoid total 0,0002543 mg QE/g ekstrak dan cemaran mikroba 3,3×104 koloni/ml. Pembuatan teh jantung pisang dengan tambahan pemanis alami stevia memenuhi standar mutu produk teh herbal.Kata kunci: Teh herbal; jantung pisang; daun stevia; variasi suhu  ABSTRACTBasic ingredient innovation that can be used as herbal tea is banana blossom, because of its secondary metabolites such flavonoids, coumarins and phenolic groups. This study aims to make banana blossom herbal tea and determine the quality standard. Formulation of herbal tea by varying drying temperature of 50°C; 90°C; 110°C and drying time 110; 130; 150 minutes, the quality standard test and herbal tea powder screening were carried out. Results of herbal tea quality: water content (7.1%; 6.8%; 2.3%), extract content in water (5.96%; 8.6%; 5 0.76%), ash content total (7.4%; 6.2%; 3.9%) water soluble ash content (4.62%; 7.88%; 10.09%) acid insoluble ash content (0.93%; 0, 7%, 0.47%, total flavonoid content 0.0002543mg QE/g extract, microbial contamination 3.3×104 colonies/ml. Formulation of banana blossom tea with the addition of natural sweetener stevia meets the quality standards of herbal tea products,Keywords: Herbal tea; banana blossom; stevia leaf; temperature variation
Uji Efek Imunumodulator Vco (Virgin Coconut Oil) Pada Tikus Jantan Sebayang, Loraetta Brety; Hasibuan, Ahmad Syukur
JURNAL BIOS LOGOS Vol 11, No 2 (2021): JURNAL BIOS LOGOS
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jbl.v11i2.35663

Abstract

(Article History: Received August 25, 2021; Revised Sept 17, 2021; Accepted Sept 20, 2021) ABSTRAKVirgin coconut oil merupakan minyak kelapa murni.VCO mengandung Medium Chain Fatty Acid (MCFA) yang memiliki pengaruh dalam meningkatkan sistem imunitas. Penelitian ini bertujuan untuk menguji efek imunomodulator VCO terhadap aktivitas fagositosis dan nilai titer antibodi pada tikus jantan. Kelompok uji bersihan karbon dibagi menjadi 5 kelompok dengan masing-masing terdiri dari 5 tikus yaitu kelompok suspensi CMC Na 0,5%, Imboost dosis 30 mg/kgBB, virgin coconut oil 5 ml/KgBB, 10 ml/KgBB,15 ml/KgBB. Perlakuan diberikan sehari sekali selama tujuh hari dan hari ke delapan dilakukan uji imunomodulator dengan metode bersihan karbon. Kelompok perlakuan uji titer antibodi sama seperti di atas selain kontrol positif menggunakan levamisole dosis 25 mg/kgBB diberikan secara oral selama 14 hari. Hasil penelitian menunjukkan bahwa VCO 5 ml/KgBB, 10 ml/KgBB, 15 ml/KgBB meningkatkan aktivitas fagositosis sel makrofag dibandingkan dengan Na-CMC 0,5% (P<0,05) dan berpengaruh secara signifikan meningkatkan pembentukan antibodi sel imun tikus jantan.Kata Kunci: Virgin coconut oil; imunomodulator; fagositosis; titer antibodi ABSTRACTVirgin coconut oil (VCO) is pure coconut oil. VCO contains Medium Chain Fatty Acid (MCFA) which has an influence increased immune system. This study was to determine the immunomodulatory effect of VCO on phagocytic activity and antibody titer values in male rats.The carbon clearance test group was divided into 5 groups with 5 rats each of 0.5% CMC Na suspension, Imboost dose of 30 mg/kgBW, Virgin coconut oil 5 ml/KgBW, 10 ml/KgBW, 15 ml/KgBW. The treatment was given once a day for seven days, on the eight day immunomodulatory test was performed use carbon clearance method. The antibody titer test treatment group was same, except for the positive control, levamisole at a dose of 25 mg/kgBW orally for 14 days. The results showed that VCO 5 ml/KgBB, 10 ml/KgBB, 15 ml/KgBB significantly increased macrophage cell phagocytic activity compared to 0.5% Na-CMC (P<0.05) and could increase cell antibody formation immunity of male mice significantly.Keywords: Virgin coconut oil; immunomodulator; phagocytosis; antibody titer
EFEKTIVITAS KERASIONALAN PEMBERIAN ANTIDIABETIK PENGOBATAN ORAL PASIEN DIABETES MELLITUS PADA USIA 30-50 TAHUN TIPE 2 DI RAWAT INAP PENYAKIT DALAM RSUD DELI SERDANG LUBUK PAKAM TAHUN 2020 Sebayang, Loraetta Brety; Anna Teresia Marbun, Romauli; Kartika, Dewi
Jurnal FARMASIMED (JFM) Vol 3 No 2 (2021): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v3i2.582

Abstract

Background: Diabetes Mellitus is a chronic condition, which occurs because the body cannot produce insulin, normally or insulin cannot work effectively. Objective: To determine the effectiveness of the rational administration of antidiabetic, oral treatment of diabetes mellitus patients at the age of 30-50 years type 2 in Deli Serdang Hospital, lubuk pakam in 2020. Method: This study is a non-experimental type of research using descriptive methods. Results: Shows that from 72 samples of Type II Diabetes Mellitus patients at Deli Serdang General Hospital, April-July Period 2020. With the number (52.8%) of male sex patients and the number (47.2%) of type patients female genitalia and antidiabetic drugs most widely used by patients, in the period of April-July 2020, namely (20.8%) glycionion + metformin and (20.8%) insulin drugs. the use of DM drugs with the right rational indication (65.3%), Rational with the right medicine (100%), rational with the right dosage (100%), the right rational patient (100%) and the rational way of administration (100:%). Conclusion: Evaluation of drug use is a structured quality assurance process that is carried out continuously to ensure that the drugs used are appropriate, safe, and efficient.
Co-Authors Anna Teresia Marbun, Romauli Dewi Kartika Hasibuan, Ahmad Syukur Sihotang, Samuel Sinulingga, Siska Esperanza