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All Journal Window of Health : Jurnal Kesehatan Proceeding Banten International Conference on Health Advancement & Research (BINAR)
Venny Patricia
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Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Angiotensin Converting Enzyme (ACE) Inhibitory Activity, Toxicity Test, and Phytochemical Analysis of Roselle Flower Extract Yani, Ahmad; Venny Patricia
Window of Health : Jurnal Kesehatan Vol 7 No 3 (July 2024)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.v7i2.1320

Abstract

Hypertension is still one of the biggest health problems in the world, including in Indonesia. The high prevalence rate has encouraged a lot of research to find antihypertensive drugs and other alternative healing methods, especially those using natural ingredients. One plant that has antihypertensive activity is the roselle flower (Hibiscus sabdariffa L.). This research aimed to observe the inhibitory activity of roselle flower extract on the angiotensin-converting enzyme (ACE), determine the potential toxicity of roselle flower extract on shrimp larvae (Artemia salina Leach), and determine the phytochemical content in it. Roselle flower simplicia was extracted using the maceration method using a 70% ethanol solvent. The extract obtained was then tested for its inhibitory activity against ACE photometrically using a microplate reader. The observed inhibitory activity was calculated in terms of IC50. The toxicity of the extract was determined by the brine shrimp lethality test (BSLT) to see how toxic the roselle flower extract was to shrimp larvae. The secondary metabolite content in the extract was determined qualitatively and quantitatively. The research results showed that the extraction yield obtained was 32,63%. The IC50 value of roselle flower extract against ACE was 295,36 ppm. The toxicity test on shrimp larvae showed that the LC50 value obtained was 334,02 ppm. The results of qualitative phytochemical tests show that roselle flower extract contained flavonoids, quinones, and steroids. The flavonoids and phenolic content in roselle flower extract were 0,42% and 0,91%, respectively. Based on these results, the phytochemical content of roselle flower extract inhibited ACE activity, and its compounds can be used as ingredients for developing hypertension drugs
THE EFFECT OF DECORATED SPICED DRINK ON TOTAL CHOLESTEROL AND BLOOD GLUCOSE LEVELS IN PATIENTS WITH HYPERCHOLESSOROLEMIA Khansa Fatin Salsabila; Nurmeily Rachmawati; Venny Patricia
Proceeding of Banten Internasional Conference on Health Advancement and Research Vol. 1 No. 1 (2026): Proceeding Banten International Conference on Health Advancement & Research (BI
Publisher : Poltekkes Kemenkes Banten

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Abstract

Hypercholesterolemia is one of the main risk factors for cardiovascular diseases that can be influenced by lifestyle and dietary patterns, including the consumption of herbs or spices. This study aims to determine the effect of administering herbal drink decoctions on total cholesterol levels and random blood glucose in patients with hypercholesterolemia. This study uses a Quasi-Experiment method with control and treatment groups design. The research subjects were divided into two groups: one group received the herbal drink decoction and the control group received no treatment. The parameters measured were total cholesterol levels and random blood glucose through laboratory tests before and after the treatment. The results of this study showed that the average cholesterol level in the treatment group before the intervention was 220 mg/dL, and after the intervention to 210 mg/dL. The results of total cholesterol levels in the control group before the intervention amounted to 173 mg/dL, for after the intervention to 185 mg/dL. The results for blood glucose levels in the treatment group before the intervention were 92 mg/dL and after the intervention to 97 mg/dL. Then for the results of temporary blood glucose levels in the control group before the intervention amounted to 88 mg/dL and after the intervention amounted to 90 mg/dL).The results of the statistical tests showed that H0 was accepted, which means there was no significant effect of administering herbal drink decoctions on total cholesterol levels and random blood glucose. Thus, the herbal drink infusion was not proven effective in lowering both parameters in patients with hypercholesterolemia. This study was conducted in the Pondok Kacang Barat area.
Co-Authors ahmad yani Khansa Fatin Salsabila Nurmeily Rachmawati