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All Journal Bali Dermatology and Venereology Journal Journal of General Procedural Dermatology and Venereology Indonesia
Alviariza, Annisa
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Incidence and characteristic of psoriasis patients at Sanjiwani Gianyar Regional Hospital 2018-2019 Alviariza, Annisa; Widyawati, Sayu
Bali Dermatology and Venereology Journal Vol 3, No 2 (2020)
Publisher : DiscoverSys Inc

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/bdv.v3i2.39

Abstract

Introduction: psoriasis is a chronic inflammatory skin disease that is characterized by firmly demarcated red plaque covered by a thick squama as a result of impaired proliferation and differentiation of the epidermis. Diagnosis of psoriasis is based on history taking and clinical features. Treatment is determined based on the patient's clinical characteristics and the severity of the disease. Purpose: this retrospective study aims to determine the incidence, characteristics and treatment options of psoriasis patients in the dermatovenereology polyclinic of Sanjiwani Gianyar Regional Hospital in 2018-2019. Methods: retrospective study of psoriasis patients at Sanjiwani Gianyar Regional Hospital in 2018-2019. Data collected from medical records includes sociodemographic data, clinical data and patient treatment history. Results: Within two years, there were 53 new cases of psoriasis. The dominance of psoriasis cases were found in men with a ratio of women and men 1:2,31. From total 53 patients, 37 were male (69,81%)and 16 female patients (30,19%). The most common type was psoriasis vulgaris (73,58%). The most age group was 31-45 years. The most commonly given regimen of therapy was topical corticosteroids plus oral antihistamines (45,28%). The most widely given systemic therapy was methotrexate. Accompanying skin infections were found in 6 cases of psoriasis (11,32%). Conclusion: Based on the results of the study, there were 53 new cases of psoriasis in 2018-2019, psoriasis vulgaris was the most common, the most age group was 31-45 years old, topical corticosteroids plus antihistamines were still the main treatment options for psoriasis patients in Sanjiwani Gianyar Regional Hospital.
Histoid leprosy mimicking lichen planus Kimberly, Kesya; Alviariza, Annisa; Ferina, Siti Aisha Nabila; Esti, Prima Kartika; Peranginangin, Lenti Br.; Komarasari, Eka
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 2
Publisher : UI Scholars Hub

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Background: Histoid leprosy is a rare variant of lepromatous leprosy (LL), characterized by unique clinical, histopathological, and microbiological features. This type of leprosy is caused by multidrug therapy (MDT) drug resistance, train mutation of Mycobacterium leprae, or genetic factors. Case Illustration: A 21-year-old Indonesian woman with a family history of histoid leprosy complained of multiple hypo-esthetic erythematous partly flat-topped papules around the lesion on the face and bilateral superior and inferior extremities for the last two years. A Slit-skin smear examination revealed acid-fast bacilli with a bacterial index (BI) of 4.17+ and morphological index (MI) of 1%. Histopathological examination on hematoxylin & eosin (H&E) stained revealed epidermal atrophy, Grenz zone, and bundles of thin spindle-like histiocytes with Virchow cells. Ziehl-Nielsen stain showed copious acid-fast bacilli. Therefore, the diagnosis of histoid leprosy was established. Discussion: Lichen planus (LP) was considered because LP typically presents as pruritic, polygonal, violaceous flat-topped papules with symmetric distribution on the flexural surfaces of the forearms, wrists, and ankles, as well as the dorsal surface of the hands and shins. However, the face is rarely affected in LP. The patient’s slit-skin smear and histopathological examinations presented strong evidence for histoid leprosy. Treatment with an MDT regimen resulted in clinical improvements as the erythematous lesions transformed into hyperpigmentation after weeks of treatment. Conclusion: Histoid leprosy mimicking LP lesions in this patient developed without any prior administration of agents. Additionally, the patient had a high bacillary load, indicating a potential reservoir of the infection as the patient had a family history of leprosy.
Co-Authors Esti, Prima Kartika Ferina, Siti Aisha Nabila Kimberly, Kesya Komarasari, Eka Peranginangin, Lenti Br. Widyawati, Sayu