Plant disease identification is essential for enhancing agricultural productivity and promoting sustainable crop management practices. Jatropha curcas has considerable potential as a biofuel-producing plant; however, its growth and productivity can be significantly affected by various leaf diseases. Conventional disease diagnosis often requires substantial time and relies heavily on expert knowledge, creating a need for automated solutions based on deep learning techniques. Although deep learning has been widely applied in plant disease recognition, comparative studies focusing on transfer learning models for Jatropha leaf disease classification remain limited, particularly for datasets characterized by distinctive visual features and relatively small sample sizes. This research conducts a comparative assessment of several deep learning architectures to determine the most effective model for classifying Jatropha leaf diseases. The evaluated architectures include MobileNetV2, EfficientNetB0, ResNet50, DenseNet121, and VGG16. All models utilized ImageNet pre-trained weights and were adapted through fine-tuning of the final classification layers to accommodate a dataset containing healthy and diseased Jatropha leaf images. Experimental findings reveal that ResNet50 achieved the highest classification accuracy of 93.81%, followed by VGG16 at 93.58% and EfficientNetB0 at 90.49%. In comparison, DenseNet121 and MobileNetV2 attained accuracies of 85.40% and 74.56%, respectively. Model effectiveness was assessed using accuracy, training duration, confusion matrix analysis, and ROC curve evaluation to examine classification capability across categories. The results demonstrate that ResNet50 offers the most balanced combination of predictive accuracy and performance stability. Overall, the study confirms that transfer learning-based deep learning models are highly effective for Jatropha leaf disease classification, with ResNet50 emerging as the most suitable architecture among those investigated. These findings may serve as a valuable reference for the development of reliable and efficient plant disease detection systems in agricultural environments.