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Mekanisme Potensial Peningkatan Derajat Keparahan Infeksi COVID-19 – Diabetes Mellitus Muhammad, Innou Dhanu
Wellness And Healthy Magazine Vol 3, No 1 (2021): February
Publisher : Universitas Aisyah Pringsewu (UAP) Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/well.147312021

Abstract

Penyakit Coronavirus 2019 (COVID-19) adalah penyakit infeksi virus yang disebabkan oleh virus corona yang menimbulkan sindrom pernafasan akut parah, coronavirus 2 (SARS-CoV-2). Individu dengan diabetes mellitus (DM) lebih mungkin terinfeksi dan berisiko lebih tinggi mengalami komplikasi dan kematian akibat COVID-19. Selain itu, COVID-19 juga dapat mempengaruhi individu yang terinfeksi menjadi hiperglikemia. Berinteraksi dengan faktor risiko lain, hiperglikemia dapat memodulasi respons imun dan inflamasi, sehingga membuat pasien rentan terhadap COVID-19 yang parah dan kemungkinan hasil yang lebih mematikan. Agen penurun glukosa dan perawatan anti-virus dapat memodulasi risiko, tetapi batasan penggunaan dan potensi interaksi mereka dengan perawatan COVID-19 harus dinilai dengan cermat. Perhatian yang lebih intensif harus diberikan pada pasien dengan diabetes, dalam kasus kerusakan yang cepat. Abstract: Coronavirus disease 2019 (COVID-19) is a viral infectious disease caused by the coronavirus, severe acute re- respiratory syndrome coronavirus 2 (SARS-CoV-2). Individuals with diabetes mellitus (DM) more likely to be infected and are at a higher risk for complications and death from COVID-19. Furthermore, COVID-19 might also predispose infected individuals to hyperglycemia. Interacting with other risk factors, hyperglycemia might modulate immune and inflammatory responses, thus predisposing patients to severe COVID-19 and possible lethal outcomes. Glucose-lowering agents and anti-viral treatments can modulate the risk, but limitations to their use and potential interactions with COVID-19 treatments should be carefully assessed. More intensive attention should be paid to patients with diabetes, in case of rapid deterioration.
PENATALAKSANAAN HOLISTIK PADA WANITA USIA 54 TAHUN DENGAN HIPERTENSI, DM TIPE 2 DAN HIPERKOLESTEROLEMIA MELALUI PENDEKATAN KEDOKTERAN KELUARGA DI WILAYAH KERJA PUSKESMAS KARANG ANYAR Muhammad, Innou Dhanu; Saftarina, Fitria
Medula Vol 14 No 7 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i7.1340

Abstract

Hypertension is a condition when blood pressure in the blood vessels increases chronically. Data from the World Health Organization (WHO) in 2015 showed that the incidence of hypertension in the world reached 1.13 billion and in 2025 the number of hypertension sufferers will continue to increase to reach 1.5 billion individuals. Type 2 DM is a metabolic disease characterized by hyperglycemia due to insufficiency of insulin secretion by pancreatic beta cells or impaired insulin function. According to the International Diabetes Federation (IDF), it is estimated that one in 11 adults or 90 million people (aged 20-79 years) in Southeast Asia will suffer from DM in 2021. Hypercholesterolemia is a condition characterized by high levels of cholesterol in the blood. According to (Riskesdas) 2018, it shows 21.2% of the Indonesian population aged ≥ 15 years. Hypertension, type 2 diabetes mellitus (T2DM) and hypercholesterolemia are chronic disease disorders that are interrelated with each other due to overlapping risk factors such as endothelial dysfunction, vascular inflammation, arterial remodeling, atherosclerosis, dyslipidemia and obesity. There are many cardiovascular complications in diabetes and hypertension, especially related to microvascular and macrovascular diseases such as stroke, heart failure, kidney disease, retinopathy, neuropathy and amputation. To reduce morbidity and mortality rates, Evidence Based Medicine-based service management is carried out in patients by identifying risk factors, clinical problems, and patient management based on a patient problem-solving framework with a patient-centered, family-focused and community-oriented approach. This study is a case report. Primary data were obtained through anamnesis, physical examination and home visits to assess the physical environment. Assessment based on a holistic diagnosis from the beginning, process, and end of the study qualitatively and quantitatively.