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All Journal Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Buletin Farmatera JURNAL ILMIAH SIMANTEK Muhammadiyah Journal of Nutrition and Food Science (MJNF) Journal Of Human And Education (JAHE)
NASUTION, MUHAMMAD EDY SYAHPUTRA
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Journal : Buletin Farmatera

 1 
Comparison of the Effectiveness of 2% Acetic Acid and Mineral Oil on Serum Prop Children of Aisyiyah Orphanage Medan in Vitro Kasibu, Raja Sun Daffa; Nasution, Muhammad Edy Syahputra
Buletin Farmatera Vol 10, No 2 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v10i2.24497

Abstract

Abstract: Serum prop is an accumulation of a substance secreted by the sebaceous glands and seruminous composed also with corneal desquammation from the stratum corneum in the ear canal which can cause symptoms or interfere with the assessment of the ear canal, tympanic membrane, and audiovestibular system. Corrosive acetic acid can destroy serum prop as well as mineral oil as a lubricant that can make cerumen come out of the ear canal. This study aims to analyze the comparison of the effectiveness of 2% acetic acid and mineral oil on serum prop children of the Putri Aisyiyah Orphanage Medan in vitro at 5, 10, 15, and 30 minutes. This study is an in vitro experimental with a quasy experimental  type using a simple random sampling  technique involving 25 serum prop samples, each sample will be tested with 2% acetic acid and mineral oil with a UV-Vis spectrophotometer. The data collected were analyzed using the ANOVA repeated measures parametric test  and the non-parametric Kruskal wallis test. The intervention of 2% acetic acid and mineral oil  on in vitro cerumen  was most significant at 30 minutes, In comparison the effectiveness of 2% acetic acid  was obtained higher results than mineral oil  against in vitro cerumen which was known from the mean difference  in each test solution. 2% acetic acid has a higher effectiveness against in vitro  serum intervention compared to mineral oil.
Comparative In Vitro Analysis of Propolis and 3% Hydrogen Peroxide as Cerumenolytic Agents in Children Ritonga, Doli Naufal; Nasution, Muhammad Edy Syahputra
Buletin Farmatera Vol 12, No 1 (2027)
Publisher : Universitas Muhammadiyah Sumatera Utara

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Abstract

Abstract: Cerumen impaction is a common otologic problem that can impair hearing and predispose individuals to external ear infections. This in vitro study aimed to compare the cerumenolytic effects of propolis and 3% hydrogen peroxide using spectrophotometric absorbance measurements at 5, 10, 15, and 30 minutes. A total of 48 cerumen samples were collected from children at Panti Asuhan Putri Aisyiyah Medan and divided equally into two treatment groups. Absorbance values were analyzed using non-parametric statistical tests due to non-normal data distribution. Propolis demonstrated a progressive increase in absorbance over time, reaching its highest effect at 30 minutes, whereas hydrogen peroxide showed minimal changes with no significant time-dependent pattern. Comparative analysis revealed that propolis produced significantly higher absorbance values than hydrogen peroxide at all time points (p 0.001), indicating superior cerumen dissolution. These findings suggest that propolis may serve as a more effective and potentially safer alternative to hydrogen peroxide for cerumen management. Further in vivo and clinical studies are recommended to validate its therapeutic applicability and long-term safety.
Co-Authors Fayyaza, Nesya Alya Kasibu, Raja Sun Daffa Khalida, Bella Nur NANTIKA SITOMPUL, ASMA DWI Ritonga, Doli Naufal Salim, Muhammad Alip Meruza Sinaga, Nurcahaya