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All Journal Journal of Epidemiology and Public Health Journal of Health Promotion and Behavior
Hapsari, Dini
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Medicine & Pharmacology Public Health

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The Effect of Metformin Use on Mortality of COVID-19 Patients with Diabetes Mellitus Hapsari, Dini; Zainal, Dwi Trisnawati
Journal of Epidemiology and Public Health Vol. 7 No. 2 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2022.07.02.07

Abstract

Background: COVID-19 is a disease caused by infection with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). COVID-19 is still a worldwide threat because of its high morbidity and mortality. This is influenced by the occurrence of hypertension, obesity, age and diabetes mellitus. However, currently there is still controversy in the results of research regarding the use of metformin in COVID-19 with type 2 diabetes mellitus (type 2 DM). This study was aimed to analyze the effect of metformin in COVID-19 patients with diabetes mellitus on mortality rates.Subjects and Method: This study was a systematic review and meta-analysis with the following PICO. P: COVID-19 patient with type-2 diabetes mellitus. I: administration of metformin therapy. C: therapy other than metformin and O: mortality. The articles used in this study were obtained from several databases, namely PubMed, Science Direct, Proquest, SpringerLink, Google Scholar and Scopus. The article search keywords were: “COVID-19” OR “coronavirus” AND “diabetes” AND “metformin” AND “mortality.” Articles included are full-text English using a cohort study design from 2020 to 2021 and reporting the Odds Ratio in multivariate analysis. The selection of articles was carried out using the PRISMA flow chart. The articles were analyzed using the Review Manager 5.3 application.Results: A total of 7 cohort studies involving 136,321 COVID-19 patients from the Americas (USA and Alabama United States), Europe (France and Spain), and Asia (China and South Korea) were selected for systematic review and meta-analysis. The data collected showed that COVID-19 patients with diabetes mellitus who were given metformin reduced the risk of death by 0.90 times higher compared to COVID-19 patients with diabetes mellitus who were not given metformin therapy (aOR= 0.90; CI 95%= 0.68 to 1.19; p=0.450).Conclusion: Metformin can reduce the risk of death in COVID-19 patients with diabetes mellitus. Keywords: Diabetes, COVID-19, SARS-CoV-2, metformin, mortality Correspondence:Dwi Trisnawati Zainal. Masters Program of Public Health Science, Universitas Sebelas Maret. Jl. Ir. Sutami 36A Surakarta 57126, Central Java. Email: dwitrisnawatiz@gmail.com. Mobile: +62-8133-1282-009.
Effect of Mobile Application Use on Oral Hygiene among Orthodontics Users: Meta-Analysis Hapsari, Dini; Pamungkasari, Eti Poncorini; Demartoto, Argyo
Journal of Health Promotion and Behavior Vol. 9 No. 1 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/thejhpb.2024.09.01.04

Abstract

Background: The high prevalence of malocclusion causes the need for orthodontic treatment to increase. The results of the 2018 National Basic Health Research, the prevalence of dental and oral problems is 57.6%, especially in adolescents. Oral hygiene is an important factor that must be controlled by patients during orthodontic treatment because it can affect the quality and time of treatment. The mobile application is here to facilitate and provide optimal dental health informa­tion to orthodontic users. This study aims to analyze and estimate the influence of mobile applications on oral hygiene in orthodontic users. Subjects and Method: This study used a systematic review and meta-analysis by following PICO, Population: orthodontic patients. Interventions: mobile applications. Comparation: without a mobile application. Outcome: oral hygiene. The data used were obtained from scientific research articles from electronic databases including Pubmed, Google Schoolar, Science Direct Randomized Control Trial (RCT) designs from 2013 to 2023 which report effect sizes with Mean and SD. The keywords used are “orthodontic” AND “oral hygiene” OR “oral health” AND “mobile application” OR “app”. The selection of articles was carried out using the PRISMA flowchart. Data were analyzed using Review Manager software version 5.3. Results: A total of 9 articles with eligible RCT designs from Asia and Europe were selected for the systematic review and meta-analysis. The results of the meta-analysis showed that oral hygiene for orthodontic users who used mobile applications was better than those who did not use mobile applications, and was statistically significant (SMD= -0.59; 95% CI= -0.90 to 0.29; p= .001). Conclusion: Mobile application improves oral hygiene in orthodontic users.
The Effect of Metformin Use on Mortality of COVID-19 Patients with Diabetes Mellitus Hapsari, Dini; Zainal, Dwi Trisnawati
Journal of Epidemiology and Public Health Vol. 7 No. 2 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2022.07.02.07

Abstract

Background: COVID-19 is a disease caused by infection with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). COVID-19 is still a worldwide threat because of its high morbidity and mortality. This is influenced by the occurrence of hypertension, obesity, age and diabetes mellitus. However, currently there is still controversy in the results of research regarding the use of metformin in COVID-19 with type 2 diabetes mellitus (type 2 DM). This study was aimed to analyze the effect of metformin in COVID-19 patients with diabetes mellitus on mortality rates.Subjects and Method: This study was a systematic review and meta-analysis with the following PICO. P: COVID-19 patient with type-2 diabetes mellitus. I: administration of metformin therapy. C: therapy other than metformin and O: mortality. The articles used in this study were obtained from several databases, namely PubMed, Science Direct, Proquest, SpringerLink, Google Scholar and Scopus. The article search keywords were: “COVID-19” OR “coronavirus” AND “diabetes” AND “metformin” AND “mortality.” Articles included are full-text English using a cohort study design from 2020 to 2021 and reporting the Odds Ratio in multivariate analysis. The selection of articles was carried out using the PRISMA flow chart. The articles were analyzed using the Review Manager 5.3 application.Results: A total of 7 cohort studies involving 136,321 COVID-19 patients from the Americas (USA and Alabama United States), Europe (France and Spain), and Asia (China and South Korea) were selected for systematic review and meta-analysis. The data collected showed that COVID-19 patients with diabetes mellitus who were given metformin reduced the risk of death by 0.90 times higher compared to COVID-19 patients with diabetes mellitus who were not given metformin therapy (aOR= 0.90; CI 95%= 0.68 to 1.19; p=0.450).Conclusion: Metformin can reduce the risk of death in COVID-19 patients with diabetes mellitus. Keywords: Diabetes, COVID-19, SARS-CoV-2, metformin, mortality Correspondence:Dwi Trisnawati Zainal. Masters Program of Public Health Science, Universitas Sebelas Maret. Jl. Ir. Sutami 36A Surakarta 57126, Central Java. Email: dwitrisnawatiz@gmail.com. Mobile: +62-8133-1282-009.
Effect of Mobile Application Use on Oral Hygiene among Orthodontics Users: Meta-Analysis Hapsari, Dini; Pamungkasari, Eti Poncorini; Demartoto, Argyo
Journal of Health Promotion and Behavior Vol. 9 No. 1 (2024)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/thejhpb.2024.09.01.04

Abstract

Background: The high prevalence of malocclusion causes the need for orthodontic treatment to increase. The results of the 2018 National Basic Health Research, the prevalence of dental and oral problems is 57.6%, especially in adolescents. Oral hygiene is an important factor that must be controlled by patients during orthodontic treatment because it can affect the quality and time of treatment. The mobile application is here to facilitate and provide optimal dental health informa­tion to orthodontic users. This study aims to analyze and estimate the influence of mobile applications on oral hygiene in orthodontic users. Subjects and Method: This study used a systematic review and meta-analysis by following PICO, Population: orthodontic patients. Interventions: mobile applications. Comparation: without a mobile application. Outcome: oral hygiene. The data used were obtained from scientific research articles from electronic databases including Pubmed, Google Schoolar, Science Direct Randomized Control Trial (RCT) designs from 2013 to 2023 which report effect sizes with Mean and SD. The keywords used are “orthodontic” AND “oral hygiene” OR “oral health” AND “mobile application” OR “app”. The selection of articles was carried out using the PRISMA flowchart. Data were analyzed using Review Manager software version 5.3. Results: A total of 9 articles with eligible RCT designs from Asia and Europe were selected for the systematic review and meta-analysis. The results of the meta-analysis showed that oral hygiene for orthodontic users who used mobile applications was better than those who did not use mobile applications, and was statistically significant (SMD= -0.59; 95% CI= -0.90 to 0.29; p= .001). Conclusion: Mobile application improves oral hygiene in orthodontic users.
Co-Authors Argyo Demartoto, Argyo Eti Poncorini Pamungkasari Zainal, Dwi Trisnawati