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All Journal Biotropika JSMARTech : Journal of Smart Bioprospecting and Technology
Budiarti, Sarah Fadilah
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Molecular Docking Analysis of α-Tomatine and Tomatidine to Inhibit Epidermal Growth Factor Receptor (EGFR) Activation in Non-Small-Cell Lung Cancer (NSCLC) Amalia, Intan Fitri; Sayyidah, Assyifa; Larasati, Kirana Aisyah; Budiarti, Sarah Fadilah
JSMARTech: Journal of Smart Bioprospecting and Technology Vol 2, No 1 (2020)
Publisher : JSMARTech

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jsmartech.2020.002.01.1

Abstract

The use of chemical drugs is the most common option for NSCLC therapy but mostly it has side effects,suchasdiarrhea,skinproblems,excessivebodyfeeling,andmouthsores.Therefore,NSCLC therapy using herbal medicine from plant bioactive compound began to be developed to minimize the side effect of chemical drugs consumption. Tomato (Lycopersiconesculentum Mill.) is one of the herbal source which contains bioactive compounds such as α-tomatine and tomatidine. The aims of this study is to analyze the effectiveness of α-tomatine, tomatidine, and combination of both of them to inhibit EGFR activity by molecular docking. The ligand and protein preparations were done using Discovery Studio 2016 then Hex 8.0.0 is used for docking. Visualization were done using Discovery Studio 2016 as well. Alpha tomatine, tomatidine, and combination of both of them have potential as inhibitors of the interaction between EGFR and EGF as native ligands. Combination alpha tomatine and timitidine have the best results among other complex that has been tested with thread of alpha tomatine applied before tomatidine. Alpha tomatine and tomatidine can be considered as drugs that can control overexpression of EGFR and decrease activation of one of the lung cancer signaling pathways. 
A Comparative Study of the Secondary Metabolite from Talinum triangulare (Jacq.) Willd. Methanolic Extract from Malang and Kediri, East Java Budiarti, Sarah Fadilah; Fatchiyah, Fatchiyah
Biotropika: Journal of Tropical Biology Vol. 10 No. 2 (2022)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.biotropika.2022.010.02.09

Abstract

Talinum triangulare is a medicinal plant that has been used broadly by the Indonesia community because of its properties. Several studies have proven the components of secondary metabolites in T. triangulare. However, the content of secondary metabolites in each part of T. triangulare is not clearly understood. Therefore, this study aimed to analyse the types of secondary metabolites of leaf, stems, and roots of T. triangulare. The plant from Malang was chosen as the sample source because it is a highland suitable for the life of T. triangulare. The plant from Kediri was chosen as a lowland location. Samples of leaves, stems, and roots of T. triangulare were extracted by maceration method. Phytochemical analyses include phenolics, flavonoids, alkaloids, tannins, saponins, and terpenoids. The absorbance values were measured at different wavelengths. The leaf and stems of T. triangulare contain flavonoid compounds, tannins, phenolics, alkaloids, saponins, and terpenoids with higher levels of secondary metabolites in the leaf. While the roots have the lowest secondary metabolite was only containing steroids. The differential levels and types of secondary metabolites samples obtained from Kediri tend to be lower than samples obtained from Malang. These results indicate that the leaf metabolite secondary of T. triangulare has high potential health benefits for regulating molecular and cellular metabolism.
Co-Authors Amalia, Intan Fitri fatchiyah . Larasati, Kirana Aisyah Sayyidah, Assyifa