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All Journal EKSAKTA: Journal of Sciences and Data Analysis Makara Journal of Science
Ningsih, Zubaidah
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Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Materials Science & Nanotechnology

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Microencapsulation of Cosmos caudatus Kunth Extract using Sodium Alginate and In Vitro Antioxidant Activity Test Fadlila, Safina Samara Nur; Puspita, Oktavia Eka; Ningsih, Zubaidah; Safitri, Anna
Makara Journal of Science Vol. 28, No. 2
Publisher : UI Scholars Hub

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Abstract

This study aims to encapsulate Cosmos caudatus K. leaf extract in sodium alginate crosslinked with calcium chloride (CaCl2) as coating materials through freeze-drying. Antioxidant assays were performed to evaluate the applicability of the microcapsules as antidiabetic medicines. Their characteristics, antioxidant activity, and encapsulation efficiency (EE) were also examined. Results indicated that the concentration of sodium alginate and pH influenced the manufacturing process of the microcapsules. The highest EE was obtained at pH 6 and alginate concentration of 2% (w/v). The IC50 for the antioxidant activity of the microcapsules was 139.96 ± 1.094 μg/mL. Scanning electron microscopy confirmed the presence of irregular and spherical structures on the surface. Fourier transform infrared spectra showed new absorption bands at 1593.10 and 1427.59 cm−1, demexistening the existence of stretching vibrations of COO−. Absorption at 1024.14 cm−1 demonstrated C–C and C–O bond stretching vibrations in the sodium alginate–CaCl2 crosslinks. Fourier transform infrared spectrum analyses indicated that sodium alginate and CaCl2 formed chemical bonds, enabling microencapsulation. This study discovered that microencapsulation is a highly prospective and adaptable strategy for enhancing the medicinal use of plant extract.
Alginate-Based Microbeads from Encapsulated Cosmos Caudatus K. Extracts: In Vitro Release Profiles Fadlila, Safina Samara Nur; Puspita, Oktavia Eka; Ningsih, Zubaidah; Safitri, Anna
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 5, ISSUE 2, October 2024
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol5.iss2.art4

Abstract

This study aims to investigate the microencapsulation of C. caudatus K. leaves extract under optimal conditions, focusing on its potential as a therapeutic option for type 2 diabetes. In order to determine the inhibitory effect on the α-amylase enzyme, which plays a crucial role in glucose metabolism, biological activity assays were performed. The procedure of effectively encapsulating the substance was achieved at a pH level of 6 using sodium alginate at a concentration of 2% (w/v), resulting in a 77.2% percentage of encapsulation. The experiment involving the inhibition of α-amylase exhibited an IC50 value of 69.44 ± 0.924 μg/mL, demonstrating the significant biological activity of the microcapsules. The bioactive substances encapsulated in the microcapsules were released during intervals 30-120 min, at pH conditions of 2.2 and 7.4. The release of bioactive substances was only 2.32 % after 120 minutes at a pH of 2.2, whereas it increased to 64.54 % at a pH of 7.4. This discovery indicates that the microcapsules contain the capability to be utilized for the regulated delivery of drugs. The findings of this research demonstrate the potential to develop herbal medicines with therapeutic properties through microencapsulation, providing an excellent opportunity for managing type 2 diabetes.
Co-Authors Fadlila, Safina Samara Nur Oktavia Eka Puspita, Oktavia Eka Safitri, Anna