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All Journal EKSAKTA: Journal of Sciences and Data Analysis Makara Journal of Science Prosiding Seminar Nasional Pengabdian kepada Masyarakat (SINAPMAS)
Ningsih, Zubaidah
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Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Materials Science & Nanotechnology

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Microencapsulation of Cosmos caudatus Kunth Extract using Sodium Alginate and In Vitro Antioxidant Activity Test Fadlila, Safina Samara Nur; Puspita, Oktavia Eka; Ningsih, Zubaidah; Safitri, Anna
Makara Journal of Science Vol. 28, No. 2
Publisher : UI Scholars Hub

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Abstract

This study aims to encapsulate Cosmos caudatus K. leaf extract in sodium alginate crosslinked with calcium chloride (CaCl2) as coating materials through freeze-drying. Antioxidant assays were performed to evaluate the applicability of the microcapsules as antidiabetic medicines. Their characteristics, antioxidant activity, and encapsulation efficiency (EE) were also examined. Results indicated that the concentration of sodium alginate and pH influenced the manufacturing process of the microcapsules. The highest EE was obtained at pH 6 and alginate concentration of 2% (w/v). The IC50 for the antioxidant activity of the microcapsules was 139.96 ± 1.094 μg/mL. Scanning electron microscopy confirmed the presence of irregular and spherical structures on the surface. Fourier transform infrared spectra showed new absorption bands at 1593.10 and 1427.59 cm−1, demexistening the existence of stretching vibrations of COO−. Absorption at 1024.14 cm−1 demonstrated C–C and C–O bond stretching vibrations in the sodium alginate–CaCl2 crosslinks. Fourier transform infrared spectrum analyses indicated that sodium alginate and CaCl2 formed chemical bonds, enabling microencapsulation. This study discovered that microencapsulation is a highly prospective and adaptable strategy for enhancing the medicinal use of plant extract.
Alginate-Based Microbeads from Encapsulated Cosmos Caudatus K. Extracts: In Vitro Release Profiles Fadlila, Safina Samara Nur; Puspita, Oktavia Eka; Ningsih, Zubaidah; Safitri, Anna
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 5, ISSUE 2, October 2024
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/EKSAKTA.vol5.iss2.art4

Abstract

This study aims to investigate the microencapsulation of C. caudatus K. leaves extract under optimal conditions, focusing on its potential as a therapeutic option for type 2 diabetes. In order to determine the inhibitory effect on the α-amylase enzyme, which plays a crucial role in glucose metabolism, biological activity assays were performed. The procedure of effectively encapsulating the substance was achieved at a pH level of 6 using sodium alginate at a concentration of 2% (w/v), resulting in a 77.2% percentage of encapsulation. The experiment involving the inhibition of α-amylase exhibited an IC50 value of 69.44 ± 0.924 μg/mL, demonstrating the significant biological activity of the microcapsules. The bioactive substances encapsulated in the microcapsules were released during intervals 30-120 min, at pH conditions of 2.2 and 7.4. The release of bioactive substances was only 2.32 % after 120 minutes at a pH of 2.2, whereas it increased to 64.54 % at a pH of 7.4. This discovery indicates that the microcapsules contain the capability to be utilized for the regulated delivery of drugs. The findings of this research demonstrate the potential to develop herbal medicines with therapeutic properties through microencapsulation, providing an excellent opportunity for managing type 2 diabetes.
Pelatihan Meningkatkan Pengetahuan dan Manfaat Bahan Herbal sebagai Pengobatan Alternatif kepada Ibu-ibu PKK Desa Kuningan Kabupaten Blitar Kamulyan, Budi; Hakim, Lukman; Ningsih, Zubaidah
Prosiding Seminar Nasional Pengabdian kepada Masyarakat (SINAPMAS) Vol 5, No 1 (2025): Inovasi Bioteknologi untuk Kesejahteraan Masyarakat: Menuju Kampus Berdampak 202
Publisher : Universitas Negeri Malang

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Pengabdian ini bertujuan meningkatkan pengetahuan dan manfaat ramuan herbal sebagai pengobatan alternatif, memberikan contoh tentang manfaat ramuan herbal, dan mendorong masyarakat untuk mengintegrasikan pengobatan herbal dalam kehidupan sehari-hari. Ramuan Sapujagat Praktis (temu mangga, lengkuas, kencur, bunga lawang, serai, pulosari, kapulogo, bawang merah) dan Badarmomolo Praktis (temu mangga, lengkuas, bunga lawang, pulosari, kapulogo, daun sembung, adas manis, biji kemukus) yang diproduksi PT Sankara Sehat Sejahtera Badung dikemas dalam bentuk ramuan celup agar lebih praktis, higienis, dan mudah dikonsumsi secara rutin. Pelatihan diikuti 40 ibu-ibu PKK; sebelum dan setelah penyampaian materi, peserta diminta mengisi kuisioner evaluasi dengan lima pertanyaan utama terkait peningkatan pengetahuan, pemahaman manfaat, kepercayaan terhadap pengobatan herbal, serta persepsi tentang efek preventif jamu. Hasil dianalisis secara deskriptif. Peningkatan prosentase evaluasi terhadap lima pertanyaan utama berkisar 8–43%. Persepsi positif peserta terhadap konsumsi rutin ramuan Sapujagat Praktis dan Badarmolo Praktis menunjukkan potensi pemanfaatan ramuan ini dalam upaya promotif dan preventif kesehatan masyarakat, terutama dalam penguatan imunitas, pengendalian gula darah, serta dukungan fungsi hati dan ginjal. Pelatihan ini berhasil memberikan informasi berbasis bukti yang mendalam mengenai manfaat ramuan herbal, yang diharapkan dapat meningkatkan kesadaran masyarakat tentang penggunaan obat tradisional yang aman dan efektif dalam menjaga kesehatan.
Co-Authors Budi Kamulyan Fadlila, Safina Samara Nur Lukman Hakim Oktavia Eka Puspita, Oktavia Eka Safitri, Anna