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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA)
Andriawan, Riki
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics

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Burns Wound Healing Activity of Extract Gel Formula of Lidah Buaya (Aloe vera) and Senggani Leaf (Melastoma polyanthum): Aktivitas Penyembuhan Luka Bakar Formula Gel Ekstrak Lidah Buaya (Aloe vera) dan Daun Senggani (Melastoma polyanthum) Wahyuningsih, Sri; Syamsu, A. Suparlan Isya; Awaluddin, Nurhikma; Andriawan, Riki
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15251

Abstract

Aloe vera and senggani leaf can accelerate tissue regeneration, re-epithelialization, fibroblast stimulation, and collagen formation in the skin for burns wound healing. Burns wound can cause damage in the capillaries of the skin, then Aloe vera and senggani leaf were formulated into the gel formula for burns wound healing. The gel has the advantage of high water content; then it will hydrate the epidermis layer, increasing the penetration of the active substances. This study aims to formulate a gel of extract Aloe vera and senggani leaf (Melastoma polyanthum) and to evaluate the burns wound healing activity. The gel was formulated by composition of Aloe vera : senggani leaf with concentrations (0.5%: 1%); (0.5% : 3%); and (0.5% : 5%). Burns wound healing activity was observed by the diameter of the burn wound. The result showed that the gel with a concentration of (0.5%: 5%) gave a significance value of 0.692 (p >0.05) against positive control, then it was the formula that effective for burns wound healing.
Test the Antioxidant Effectiveness of Oyster Mushroom (Pleurotus ostreatus) Ethyl Acetate Fraction Cream Formula using FRAP (Ferric Reducing Antioxidant Power) and ABTS (2,2'-azino-bis (3-3) ethylbenzothiazoline-6-sulphonic acid) Methods) Nadjamuddin, Mirfaidah; Auliah, Nielma; Mulyadin; Tajuddin, Zakiah; Andriawan, Riki
Jurnal Penelitian Pendidikan IPA Vol 9 No 12 (2023): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i12.6118

Abstract

Antioxidants are compounds that can fight the influence of free radical molecules due to chemical reactions and metabolic events in the body. Phenolic compounds work to reduce the reaction of increasing the oxidation number, and are able to reduce highly reactive free radicals, lipid peroxidation processes, and metal oxides that can be obtained from oyster mushrooms. This study aims to make an antioxidant cream preparation and measure the IC50 value by conducting an antioxidant test of the ethyl acetate fraction of oyster mushroom (Pleurotus ostreotus) cream using FRAP (ferric reducing antioxidant power) and ABTS (2.2'-azino-bis (3-3) ethylbenzothiazoline-6-sulphonic acid) methods. The methods used are FRAP and ABTS where oyster mushrooms go through a liquid-liquid partition process and are made into cream preparations with formula concentrations of 2%, 4% and 6%, then their antioxidant activity is seen. The results of measuring three cream formulas obtained an IC50 value using the FRAP method of 110.12 bpj, and an IC50 value using the ABTS method of 84.61 bpj. The conclusion was that the IC50 value using the FRAP method (110.12 bpj) had medium category activity and the IC50 value using the ABTS method (84.61 bpj) had strong category activity.
Co-Authors Auliah, Nielma Mulyadin Nadjamuddin, Mirfaidah Nurhikma Awaluddin Sri Wahyuningsih Syamsu, A. Suparlan Isya Tajuddin, Zakiah