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All Journal Jurnal EECCIS Indonesian Journal of Cancer
Idhil, Andi Nurul Isri Indriany
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Biochemistry, Genetics & Molecular Biology Engineering Immunology & microbiology Medicine & Pharmacology Public Health

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Sistem Monitoring Inkubator Bayi Multifungsi dengan Fototerapi dan Ayunan Mekanis Berbasis ESP32 Idhil, Andi Nurul Isri Indriany; Fadilla, Rafa Raihan; Anggraini, Monika Ayu Puji; Dewi, Ajeng Kusuma; Sanjaya, Mochamad Rofi; Nurrohman, Muhammad Yogi; Rahmadwati, Rahmadwati
Jurnal EECCIS (Electrics, Electronics, Communications, Controls, Informatics, Systems) Vol. 14 No. 3 (2020)
Publisher : Faculty of Engineering, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/jeeccis.v14i3.668

Abstract

Abstract— Many infant mortality rates are due to premature events. Premature babies are at high risk for hypothermia and hyperbilirubinemia. To overcome this, an incubator can be used as a warmer and light therapy as blue light therapy for yellow babies. However, both medical devices have still been found using manual control. If the health worker is tired of working and manually controlling both devices, it can put the baby at risk. Multifunctional infant incubator based on ESP32, which is an infant incubator equipped with phototherapy and a mechanical swing. This multifunctional baby incubator has the ability to warm the baby's body, the baby yellow light therapy, and can calm the baby when crying. This tool can be monitored remotely using the Internet of Things (IoT). The sensors used are the DHT22 sensor and the sound sensor. Multifunctional baby incubator can make it easier for hospital or basic health care facility level to monitor baby's health in real time without being at the device location and the resulting data can be stored neatly. Keywords— Internet of Things, Monitoring, Incubator, Phototherapy. Abstrak–- Angka kematian bayi banyak disebabkan oleh kejadian prematur. Bayi prematur berisiko tinggi terhadap hipotermia dan hiperbilirubinemia. Untuk mengatasinya dapat digunakan inkubator sebagai penghangat dan fototerapi sebagai terapi sinar biru bayi kuning. Akan tetapi, masih ditemukan kedua alat kesehatan tersebut menggunakan pengontrolan secara manual. Apabila petugas kesehatan kelelahan bekerja dan melakukan pengontrolan kedua alat secara manual dapat menempatkan bayi dalam bahaya. Inkubator bayi multifungsi berbasis ESP32 yaitu inkubator bayi yang dilengkapi dengan fototerapi dan ayunan mekanis. Inkubator bayi multifungsi ini memiliki kemampuan untuk menghangatkan tubuh bayi, terapi sinar bayi kuning, dan dapat menenangkan bayi ketika menangis. Alat ini dapat dipantau dari jarak jauh menggunakan Internet of Things (IoT). Adapun sensor yang digunakan yaitu sensor DHT22 dan sensor suara. Inkubator bayi multifungsi dapat mempermudah pihak rumah sakit ataupun tingkat fasilitas pelayanan kesehatan dasar untuk mengontrol kesehatan bayi secara real time tanpa ada di lokasi alat dan data yang dihasilkan dapat tersimpan dengan rapi.Kata Kunci— Internet of Things, Monitoring, Inkubator, Fototerapi.
Evaluation of Vimentin-Positive Circulating Tumor Cells in Breast Cancer and Their Association with Pre and Post-chemotherapy Yulian, Erwin Danil; Utami, Sri Anidyo; Wulandari, Dewi; Kekalih, Aria; Idhil, Andi Nurul Isri Indriany
Indonesian Journal of Cancer Vol 20, No 1 (2026): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i1.1479

Abstract

Background: Breast cancer is the most common cancer among women worldwide, leading to 670,000 deaths globally in 2022. Epithelial-mesenchymal transition (EMT) plays a role in the metastasis of breast cancer. The EMT process begins with the invasion of cancer cells into surrounding tissues, intravasation into blood vessels, circulating tumor cells (CTCs), evasion of the immune process, and extravasation to a new location. Epithelial cells undergoing EMT are characterized by an increase in mesenchymal markers such as vimentin, which indicates migration of breast cancer cells. Previous studies have shown that EMT contributes to resistance to chemotherapy. This study aims to evaluate pre and post-chemotherapy of vimentin-positive CTCs in breast cancer patients and the association with chemotherapy. Methods: A prospective cohort study at Dr. Cipto Mangunkusumo General Hospital and Koja Hospital, Jakarta, from March to June 2024. This study obtained vimentin-positive CTCs pre- and post-chemotherapy and clinicopathological factors in 24 breast cancer patients. The inclusion criteria were patients diagnosed with breast cancer with histological subtype invasive carcinoma of no special type, and patients were eligible for chemotherapy and continued to receive first-line chemotherapy. Vimentin-positive CTCs were evaluated by using the FITC immunofluorescence technique with a BD FACSLyric flow cytometer. The association between the vimentin-positive CTCs pre- and post-chemotherapy was analysed by using the Wilcoxon test. The Mann-Whitney test was used to analyse the association between the delta number of vimentin CTCs and clinicopathological factorsResults: Total vimentin CTCs pre- and post-chemotherapy were measured in 24 patients. The delta vimentin-positive CTCs were calculated as the difference between total vimentin-positive CTCs pre-chemotherapy minus total CTCs post-chemotherapy. A significant association was observed between the vimentin-positive CTC levels pre- and post-chemotherapy (p = 0.009). Clinicopathological factor analysis showed no significant association between delta CTCs. Conclusions: The vimentin-positive CTC level in breast cancer patients was significantly reduced post received chemotherapy. Due to the small sample size, this study may have limited statistical power. This study suggests further research on vimentin-positive CTCs as predictor factors for chemotherapy response in breast cancer patients.
Co-Authors Anggraini, Monika Ayu Puji Aria Kekalih Dewi Wulandari Dewi, Ajeng Kusuma Fadilla, Rafa Raihan Nurrohman, Muhammad Yogi Rahmadwati Rahmadwati Sanjaya, Mochamad Rofi Utami, Sri Anidyo Yulian, Erwin Danil