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Novelya
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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The Effectiveness of The Combination of Nanoparticles from Carica papaya L. Leaf and Chitosan 1% Against Fibroblasts in The Tooth Socket of Wistar Rats. Sim, Mellisa; Helen Theresia Nauli; Dang Phuong Khanh; Novelya; Felice Florencia Nicoline
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.378

Abstract

Nanoparticles size can make easier for drugs to enter and react quickly to the body.In this study, nanoparticles Carica papaya L. leaf were used and combined withchitosan 1%. The aim of this study was to measure the effectiveness of thecombination of nanoparticles from Carica papaya L. leaf and chitosan 1% againstfibroblasts in the tooth socket of Wistar rats. Carica papaya L. leaf extract wasmade by maceration method and converted into a concentration of 25%, 50%, 75%and 100%, then made into nanoparticles using the nanoemulsion method. Chitosan1% was made using Na-TPP solvent using the ionic gelation method with a ratio of2:1 and after that it was mixed with nanoparticles of Carica papaya L. leaf thenmade into a gel preparation. The ANOVA statistical test shows a significant numberof p <0.05, so it can be ignored that the increase in the number of fibroblast cellsproduced by the nano gel extract is 25%, 50%, 75% and 100%, its 138, 173, 177.4and 328. Thus, the combination of 100% Carica papaya L. leaf nanoparticle extractand 1% nanocitosan was the most effective in increasing fibroblast cells on Wistarrat tooth socket.
Effectiveness of Tamarillo Skin Extract (Solanum betaceum Cav.) with Sealer Combination in Inhibiting Growth of Enterococcus faecalis E.Y, Siregar; Novelya; Susanto C
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.380

Abstract

Introduction : Caries is a growth medium for pathogenic micro-organisms an inflammatory process can occur which can cause damage to the tooth pulp. Enterococcus faecalis one of the Gram-positive facultative anaerobes which causes failure after endodontic treatment. In the field of dentistry, herbal ingredients can be used as alternative medicinal ingredients because the ingredients is tamarillo skin which contains flavonoids, terpenoids, saponins and phenol compounds. In addition to herbal alternatives, endodontic filling also uses ingredients that have antibacterial potential that can kill and prevent reproduction in the root canals, one of which is the zinc oxide eugenol sealer which is usually applied together with gutta percha. Research objective: to determine the effectiveness of the extract of tamarillo (Solanum betaccum Cav.) skin sealer combination in inhibiting the growth of Enterococcus faecalis. Method: The research was conducted in an experimental laboratory post test only control group design. Results : a sealer made from zinc oxide-eugenol had the largest diameter compared to the combination group of 100%, 75%, 50%, 25% tamarillo skin extract with sealer, and aquadest. Based on the One Way Anova test, there was a significant difference in the mean diameter of the inhibition zone (p <0.05) and the Post Hoc LSD analysis test showed that the sealer was the best group to kill the Enterococcus faecalis bacteria. Conclusion : sealers have a good effect on inhibiting Enterococcus faecalis bacteria as a cause of failure in endodontic treatment.
Correlations Between Mandibular Third Molars to Inferior Alveolar Nerve Locations in Vietnamese Population Pham Ngoc Anh Thu; Tran Nhut Thao Trang; Florenly; Novelya
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.382

Abstract

One of the probable complications in mandibular third molar extraction is thedamage to the inferior alveolar nerve (IAN). Calculating the distance between IANand third mandibular can decrease the complication risk. In this study, cone beamcomputed tomography (CBCT) scans were used to evaluate several factors relatedto the positional relationship between mandibular third molar and IAN in theVietnamese population. One-hundred-seventy-eight CBCT scans were collectedfrom dental clinics at Ho Chi Minh City, from 1st January 2018 to 28th February2021. Only 100 scans were included in this study, 55 scans of female and 45 scansof male patients. The age of the patients ranged from 19 to 59 years old. From thisstudy, the most common location of IAN relative to the roots of the mandibularthird molar was on the apical side (60.5%), followed by the buccal side (21.5%), thelingual side (16%), and the least common located between the roots (2%). Overall,the mean distance between mandibular third molar roots to IAN was 3.19±1.85mm. There was a significant correlation between the left and right sides ofthe IAN location, indicating symmetry. Moreover, there is no association was foundbetween gender and the location of IAN
Co-Authors Dang Phuong Khanh E.Y, Siregar Felice Florencia Nicoline Florenly Helen Theresia Nauli Pham Ngoc Anh Thu Sim, Mellisa Susanto C Tran Nhut Thao Trang