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All Journal Journal of Pharmaceutical and Health Research Jurnal Mitra Pengabdian Farmasi
Novita, Eva
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Humanities Environmental Science Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Aktivitas Antibakteri dan Formulasi Krim Dari Ekstrak Etanol Daun Kemangi (Ocimum basilicum L.) dan Daun Kari (Murraya koenigii L.) Safrina, Safrina; Novita, Eva; Mardhatillah, Mardhatillah; Syaddry, Alfi Yanna
Journal of Pharmaceutical and Health Research Vol 6 No 3 (2025): October 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i3.8510

Abstract

The use of medicinal plants as active ingredients in topical formulations has been increasingly explored as a natural alternative to synthetic antimicrobial agents. This study aimed to formulate and evaluate a topical cream containing a combination of ethanolic extracts of curry leaves (Murraya koenigii L.) and basil leaves (Ocimum basilicum L.) as a natural antibacterial agent against Staphylococcus aureus. The extracts were prepared through maceration using 96% ethanol, followed by phytochemical screening and antibacterial testing using the well-diffusion method against Staphylococcus aureus ATCC 25923. Phytochemical analysis confirmed the presence of alkaloids, flavonoids, phenolics, saponins, and steroids in both extracts. The antibacterial assay showed that the 1:1 extract combination produced an average inhibition zone of 14.17 mm, classified as strong and exhibiting a partial synergistic effect compared with single extracts. Several oil-in-water (O/W) cream formulations were then developed to determine optimal physical stability. Formula F2 (2:1) demonstrated the best physical stability, with pH 6 ± 0.1, spreadability of ±5 cm, adhesion time >140 seconds, and viscosity of 4500–5000 cP, all meeting the SNI 16-4399-1996 standard. These findings indicate that the 1:1 combination ratio provides the highest antibacterial activity, while the 2:1 ratio yields the most stable physical characteristics, suggesting that both can serve as the basis for developing a safe, stable, and effective natural topical antibacterial cream against Staphylococcus aureus.
Community Service Program: Socialization and Introduction of “DAGUSIBU” to Santri at BTRG Islamic Boarding School, Aceh: Pengabdian Kepada Masyarakat: Sosialisasi dan Pengenalan “DAGUSIBU” pada Santri Dayah BTRG Aceh Ida Mukhlisa; Rosa Mardiana; Lidyawati; Nurjannah; Dwi Putri Rejeki; Sasmiati Farach Dita; Novita, Eva
Jurnal Mitra Pengabdian Farmasi Vol. 5 No. 1 (2025): Oktober 2025
Publisher : Akademi Farmasi YPPM Mandiri

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Abstract

Irrational use of medicines remains a public health problem, including among adolescents in religious educational institutions. Santri living in Islamic boarding schools are required to be independent in managing their daily health needs, which may increase the risk of improper medicine use if adequate knowledge is lacking. This community service activity aimed to improve the knowledge and understanding of santri at BTRG Islamic Boarding School, Aceh, regarding proper medicine management through the socialization and introduction of the DAGUSIBU concept (Get, Use, Store, and Dispose of Medicines Properly). The activity was conducted using an educational and participatory approach, including lectures, interactive discussions, and the distribution of educational media. A total of 52 santri participated in the activity, consisting of 30 male and 22 female santri. The results showed an improvement in santri’s understanding of DAGUSIBU principles, as indicated by active participation during the sessions and their ability to explain the material after the activity. This program had a positive impact on increasing awareness of rational medicine use among santri. Therefore, continuous DAGUSIBU education is recommended to enhance health literacy in Islamic boarding school environments.
Co-Authors Ida Mukhlisa Lidyawati Mardhatillah, Mardhatillah Nurjannah Rosa Mardiana Safrina Safrina, Safrina SASMIATI FARACH DITA Syaddry, Alfi Yanna