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All Journal Jurnal Kedokteran Diponegoro Indonesian Journal of Rheumatology
Rakhma Yanti Hellmi
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Medicine & Pharmacology

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Journal : Indonesian Journal of Rheumatology

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Randomized Controlled Trial of Herbal Extracts (Eugenia polyantha, Apium graveolens, Nigella sativa) and Allopurinol Effect on Serum Uric Acid, Urinary Uric Acid and High Sensitivity C-Reactive Protein Levels in Subject with Hyperuricemia Bantar Sutoko; Rakhma Yanti Hellmi; Ika Vemillia W; Stepanus Agung L
Indonesian Journal of Rheumatology Vol. 11 No. 2 (2019): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v11i2.112

Abstract

Background: Eugenia polyantha, Apium graveolens, and Nigella sativa are extracts which in preclinical trial can reduce uric acid serum, increase urinary uric acid excretion. Allopurinol is an inhibitor of the xanthine oxidase enzyme which can also reduce the increase of hsCRP in subjetcs with hyperuricemia. Objective: To determine the safety and effect of herbal extracts in reducing serum uric acid, increasing uric acid excretion and reducing hsCRP levels in patients with hyperuricemia compared with allopurinol. Method: This study was a double blind randomized controlled trial (RCT). The subjects were hyperuricemic patients aged ³18 years. The subject was divided into groups that received 3000 mg/day of herbal extracts and allopurinol 100 mg/day for 4 weeks. Evaluation of serum uric acid and urinary uric acid urine were every week, and hsCRP levels was baseline and end of intervention. Other parameters related to the safety of use were examined every 2 weeks. Results: A number of 44 hyperucemia subjects, 23 subjects received herbal extracts and 21 subjects received allopurinol. The decrease of uric acid serum levels in the herbal extract group was 0,467±1,123;0,600;-2,70-3,00 (p=0.027), while in the allopurinol group 1,11 4±0,813;1,30;-1,30-2,30 (p=0,000). Uric acid excretion in the herbal extract group decrease 71,00±1,970;5,50;-92,00-702,00 (p=0,269) and in the allopurinol group decrease 64,54±1,298;22,00;-29,00-440,0 (p=0.003). The reduction of hsCRP in the herbal extract group was 0.08±0.639; 0.01; -1.55-2.05 (p=0.658), and the allopurinol group was -0.33 ± 0.806; -0.01; -2.73- 0.31 (p=0.256). Conclusion: Herbal extracts (Eugenia poliantha, Apium graveolens and Nigella sativa) and allopurinol can reduce serum uric acid levels in patients with hyperuricemia. Allopurinol also can reduce urinary uric acid excretion.
Characteristics of Patients with Autoimmune Rheumatic Disease in the Era of COVID-19 Pandemic in Indonesia Rudy Hidayat; Harry Isbagio; Anna Ariane; Faisal Parlindungan; Laniyati Hamijoyo; I Nyoman Suarjana; Dwi Budi Darmawati; Rakhma Yanti Hellmi; Gede Kambayana; IA Ratih Wulansari Manuaba; Awalia Awalia
Indonesian Journal of Rheumatology Vol. 12 No. 1 (2020): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v12i1.159

Abstract

Background Coronavirus Disease 2019 (COVID-19) could be fatal in high-risk patient including autoimmune rheumatic patients. Nowadays, the management of these patients becomes dilemma because the use of steroids and disease-modifying anti-rheumatic drugs could suppress the immune system however, poor control of the underlying disease increases the infection risk. Understanding the characteristics of these patients in the COVID-19 pandemic is essentials to establish management guidelines and identify patients who are more susceptible to COVID-19. This study aimed to determine the characteristics of autoimmune rheumatic patients in the era of COVID-19 pandemic in Indonesia. MethodA descriptive study using national scale survey method was conducted. The subjects were autoimmune rheumatic patients in Indonesia and recruited using consecutive sampling. The variables evaluated in this study were demographic data, history of disease, current medications taken, daily activities in the COVID-19 pandemic, and also data related to COVID-19. The surveys distributed in online form to patients with autoimmune rheumatic disease in Indonesia. ResultTotal participants in this study were 570 patients, mostly women (93.9%), aged <60 years old (97.2%), and diagnosed with systemic lupus erythematosus (62.8%). Glucocorticoid (70.2%) especially low dose glucocorticoid (52.6%) is the most medication taken by patients. A 30.5% of patients is taking hydroxychloroquine/chloroquine and 88.1% of them have good compliance. During COVID-19 pandemic, 76.5% respondents still do normal activities/work and only 53.2% use personal protective equipment. Eleven of 541 respondents had positive PCR test and confirmed to COVID-19. The risk of COVID-19 infection based on British Society of Rheumatology (BSR) scoring system showed that 57.9%, 28.6%, and 13.5% patients in high, moderate and low risk, respectively. ConclusionPatients with autoimmune rheumatic diseases might be more susceptible to COVID-19 than the general population. Interplay of aging, therapies and disease-specific factors, comorbidities and the proper use of personal protective equipment seem to contribute. Keywords :autoimmune rheumatic disease, characteristic, COVID-19, Indonesia
Co-Authors Anna Ariane Awalia Awalia Bantar Sutoko Diva Natasya Krismanita Dwi Budi Darmawati Faisal Parlindungan Gede Kambayana Harry Isbagio I Nyoman Suarjana Ika Vemillia W Laniyati Hamijoyo, Laniyati Risky Maulidah Hasanah Rivan Dwiutomo Rudy Hidayat Setyo Gundhi Pramudo Setyo Gundi Pramudo Stepanus Agung L Zulfikar Naftali