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Pradhan, Darshan
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Medicine & Pharmacology

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Recent advancement in the method of transdermal drug delivery system: A review Halder, Sudip; Chakraborty, Prodipta; Pradhan, Darshan; Bagchi, Arnab
Journal of Applied Pharmaceutical Research Vol. 9 No. 2 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.06.09

Abstract

A transdermal patch is a medicated adhesive patch that is applied to the skin and used to deliver a particular amount of medication into the bloodstream through the skin. It aids in the recovery of an injured bodily part. The transdermal drug delivery system (TDDS) provides an alternative safe means of drug delivery to previous intrusive techniques. In the past, topically applied lotions and ointments were the most commonly utilised systems for dermatological issues. The fact that some of these formulations cause systemic side effects indicates that they are absorbed through the skin. All topically applied medication formulations intended to transport the active ingredient into the general circulation are included in the transdermal delivery system. To overcome the skin's formidable barrier to topical medication administration, several substances have been utilised. Because of their unique qualities, such as improved bioavailability, regulated pharmaceutical release, and improved patient compliance, TDDS have recently gained increased attention. The current review focuses on the various advancements in transdermal drug delivery, as well as the various available methods for preparing transdermal patches, characterization and assessment tools for transdermal patch preparation, patents, transdermal compound clinical trials, and drug approved and future applications of transdermal drug delivery systems. As a result, in recent years, the Transdermal Drug Delivery System has received a lot of attention.
Current developments in prevention and treatment of candidiasis: A review Chakraborty, Prodipta; Pradhan, Darshan; Halder, Sudip; Bagchi, Arnab
Journal of Applied Pharmaceutical Research Vol. 9 No. 3 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.v9.i3.21-25

Abstract

Invasive fungus infection affects about six people out of every 100,000 people each year. Only half of these infections are detected throughout the patient's lifetime, making it one of the most common causes of death among intensive-care patients. The low detection rate is due to the diagnostic work's complexity, which comprises clinical, radiographic, and microbiological results. Antimycotic drug-resistant fungi are on the rise all over the world. Guidelines for identifying and treating invasive fungous infections caused by Candida spp., Aspergillus spp., Mucorales, and Fusarium spp. are the topic of this review. In typical hospital care, intrusive fungous infections are frequently ignored. They must include it as a necessary component of antimicrobial stewardship programmes. There is also a great need for novel antimycotic medication classes to be developed
An overview on FDA-approved natural super disintegrants efficacy in a fast dissolving drug delivery system Pradhan, Darshan; Chakraborty, Prodipta; Halder, Sudip; Bagchi, Arnab
Journal of Applied Pharmaceutical Research Vol. 9 No. 3 (2021)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2021.v9.i3.1-7

Abstract

FDTs are defined by the United States Food and Drug Administration (FDA) as a solid dosage form containing the therapeutic substance or when applied on the tongue, the active ingredient disintegrates quickly, usually within seconds. The goal of this study is to create a fast-dissolving tablet that uses natural disintegrants. Fast dissolving tablets have grown in popularity in the pharmaceutical industry in recent years. They have a quick disintegration activity that dissolves with saliva without the use of water when placed within the mouth. Furthermore, FDT aims to provide quick medication absorption, reduced toxicity, and higher drug bioavailability, and it is especially popular among geriatric and paediatric patients. Natural disintegrants, which are obtained from natural sources, have a number of advantages, including low cost, nontoxicity, biodegradability, environmental friendliness, and less adverse effects. As a result, it has been established that natural disintegrants are often safer than synthetic disintegrants. Natural disintegrants includes Chitin and chitosan, Guar gum, Gum karaya, Agar and treated agar, Fenugreek seed mucilage, Soy polysaccharide, Gellan gum, Mango peel pectin, Lepidium sativum mucilage, Plantago seed mucilage, Agele marmelos gum, Locust bean gum, Mangifera indica gum, Hibiscus rosa sinensis mucilage, Dehydrated banana powder.
Co-Authors Bagchi, Arnab Chakraborty, Prodipta Halder, Sudip