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All Journal Indian Journal of Forensic Medicine & Toxicology
Naglaa F. Mahmoud
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Public Health

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Neuroprotective Effect of Moringa Oleifera Extract on Acetamiprid Induced Neurotoxicity and Apoptosis in Albino Rats Amr A. Abdallah; Marwa A. Ibrahim; Eman A. Ibrahim; Hossam El Din H. Abdelhafez; Naglaa F. Mahmoud
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16790

Abstract

Acetamiprid (ACMP) can cause neurotoxicity and induces neuronal apoptosis. The ameliorative effects ofMoringa Oleifera (MO) seed extract against the neurotoxicity induced by ACMP in adult male albino ratswere investigated. Forty male albino rats were divided into 4 equal groups. The first group served as a control,the second group administered ACMP 26.8mg/kg b.w. (representing 1/10 LD50) by gavage. The third groupwas given combination of ACMP 26.8 mg/kg b.w. and MO seed extract 150 mg/kg b.w. the fourth group wasgiven MO extract only 150 mg/kg b.w. for 28 consecutive days. Results proved the efficacy of MO extractas a neuroprotective agent through the reduction of the oxidant parameter malondialdhyde (MDA) contentby 26.9%, significant increase of reduced glutathione content (GSH) by 21.4%, and elevation of catalase(CAT) and superoxide dismutase (SOD) activities by (62.2% and 40.8%) respectively, compared to ACMPintoxicated group. Consequently, gene expression analysis for Bax and NBN genes was downregulatedby 54.5% and 36.3% respectively in MO treated rats (group III) compared with ACMP intoxicated group.Moreover, restoration of the pathological tissue injuries was noticed. In conclusion, MO proved to be aneffective neuroprotective and anti-apoptotic agent against ACMP-induced toxicity.
Forensic Toxicology Analysis of Suicidal Hanging Deaths in Eastern Province-Saudi Arabia Naglaa F. Mahmoud; Maha K. Al-Mazroua; Moustafa M.Afify; Sahar Y. Issa
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14850

Abstract

Background: Suicide is a multifaceted phenomenon with multiple underlying risk factors, including alcoholand/or abuse of other drugs and psychiatric illnesses. Toxicological analysis is of crucial importance even inhanging deaths where the cause of death seems to be ‘obvious’. Objective: To investigate hanging suicidedeaths, focusing on toxicological findings in their postmortem specimens, over a period of six years in theEastern Province, Saudi Arabia. Methods: The suicidal hanging deaths in the period from 2014 to 2019were retrospectively studied from autopsy and toxicology analysis reports. Results: Of the investigated 75hanging suicides, 64 (85.3%) were males and 11 (14.7%) were females. Most of the cases were in the agegroup between 31 and 40 years of age (36%). Non-Saudi nationals (57, 76%) much prevailed over Saudipeople (18, 24%) and the highest is the Indian population (27, 36%), followed by Saudi nationals (18, 24%).Ethanol was the commonest detected substance in the studied specimens (45, 60%). Cannabis ranked thesecond (14, 18.6%) followed by antipsychotic drugs (10, 13.3%) and amphetamine (7, 9. 3%).Conclusion:The precise statistical mortality database for hanging suicides deaths may provide a valuable evidence forthe importance of postmortem toxicology analysis and the role of alcohol and its effect on the aggressivebehavior, human health and mortality. In the current study, Ethanol was the highest detected substance in thestudied specimens (45, 60%), with predominance of non-Saudi Indian males.
Co-Authors Amr A. Abdallah Eman A. Ibrahim Hossam El Din H. Abdelhafez Maha K. Al-Mazroua Marwa A. Ibrahim Moustafa M.Afify Sahar Y. Issa