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All Journal Indian Journal of Forensic Medicine & Toxicology
Marwan M. Merkhan
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Public Health

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Assessment of Pesticide Biohazards in Neurodegenerative Diseases; Data Analysis Statistical Study Marwan M. Merkhan; Zeina A. Althanoon; Ahmed A Mohammed; Ibrahim M. Faisal
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16961

Abstract

Background: The initiation of late onset neurodegenerative diseases remains unknown. New researchessuggested that prolonged exposure to pesticides might lead to the initiation of neurodegenerative diseases,but the results were subject to controversy. Aims: The present study aimed to demonstrate an update dataminingto compare published data for studies comparing role of pesticide in induction of neurodegenerativediseases (Parkinson’s diseases, Alzheimer’s diseases, and Amyotrophic lateral sclerosis) Results: A clearassociation has been noticed across different studies regarding correlation between pesticide exposure andParkinson’s disease or Amyotrophic Lateral Sclerosis (Odd Ratio >1), nevertheless, the association wasweaker between exposure to pesticide and the development of Alzheimer’s disease (Odd Ratio close to 1)Conclusions: There is good quality evidence that the impact of pesticide in initiation of neurodegenerativedisease is statistically approved. However, there is inconclusive evidence from randomised controlledtrials to show significant induction of neurodegeneration. More research is needed particularly long-termcontrolled studies on laboratory animals.
Fluvoxamine Provide a Gastro-Protection Against Vitiated Insult Sada W. Abdulqader; Ibrahim M. Faisal; M. G. Saeed; Marwan M. Merkhan
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17633

Abstract

The etiology of peptic ulcer disease is multifactorial and remains an enigma over the last decades. The central parameter is the acid secretion; whose control is under the coordination of gastrin, acetylcholine, histamine, and prostaglandin. The treatment of peptic ulcers is a bi-armed tool, directed toward fighting microbial growth alongside acid suppression. However recent studies reported failure of the therapy due to recurrence of symptoms. Therefore, additional parameters should be considered including patient mood and psychological status. The present study aimed to introduce a new approach to the therapeutic regimen of ulcer disease using commonly used antidepressant drugs (fluvoxamine and fluoxetine) in a laboratory animal model of peptic ulcer induced by stress insult to act as a mood upset model in an attempt to mimic mood changes in human. The study was conducted on 4 groups of laboratory animals using control negative and control positive (misoprostol) against the tested drugs group (fluvoxamine and fluoxetine group). The result confirmed that fluvoxamine confers gastroprotective effects against ulcer insult compared to both fluoxetine or misoprostol groups. These results might significantly mean that antidepressant drugs could be utilized in peptic ulcer diseases or added at low doses to prevent ulcer insults due to whatever precipitating factors, such as, infection, alcohol, smoking, NSAIDs, and stress ulcer.
Co-Authors Ahmed A Mohammed Ibrahim M. Faisal M. G. Saeed Sada W. Abdulqader Zeina A. Althanoon