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All Journal Indian Journal of Forensic Medicine & Toxicology
Mohammed Ibrahim Nader
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Public Health

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Determination the Relationship between (KLF14 rs972283) Genotype and Type 2 Diabetes in a Sample of Iraqi Patients Shaimaa Abbas Dawood; Mohammed Ibrahim Nader
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17078

Abstract

This study was aimed to detect KLF14 gene polymorphism in Iraqi type 2 diabetes mellitus patients (T2DM)to found the correlation between the SNP (rs972283) polymorphism in KLF14 gene and lipid metabolismand impact on the incidence of type 2 diabetes mellitus (T2DM). The result show high Significant differencewas observed in FBS level (P<0.001) in patient group (172.9 ± 79.73) and in control (81.16 ± 7.18),).Cholesterol, LDL-Cholesterol and VLDL-Cholesterol mean level value in diabetic patients was significantlyhigher than those of control group (p<0.0001), serum HDL-Cholesterol mean value was significantlydifference (P<0.05) in serum mean level of HDL between T2DM patients and healthy controls. Real timePCR (HRM) RT-PCR were used to detect SNP (rs972283) in KLR14 gene (G>A) by using specific primers,as a related with SNP (rs972283) G>A in KLF14 gene, genotypes and alleles frequencies, odds ratios,95% confidence intervals and P values for the KLF14 gene In this study, statistical analyses of genotypicfrequencies for the KLF14 (rs972283) revealed significant difference between T2DM patients and controlsin the examined population. GG genotype was significantly (P = 0.0006) more frequent in the patient group.The observed G/G, A/G, and A/A genotype frequencies were 50%, 42%, and 8%, respectively.The A (wildtype)and G (variant) allele frequencies were 29% and 71% , respectively in patient group while the observedG/G, A/G, and A/A genotype frequencies were 22%, 48%, and 30, respectivelyand the A (wild-type) , G(variant) allele frequencies were 54% and 46%, respectively in control group (P <0.0003). GG genotype wassignificantly (P = 0.0006) more frequent in the patient group, Conclusion: There was a relationship betweenpolymorphism of KLF14 gene SNP (rs972283) and the incidence of T2DM in sample of Iraqi patients.
Observation of Tri-allelic Patterns in Autosomal STRs during Establishment of Genetic Fingerprint Database for the Iraqi Security Forces Esam Ghazi Mohammed Salih; Mohammed Ibrahim Nader; Majeed Arsheed Sabbah; Mohammed Mahdi Al-Zubaidi; Hanan Khaleel Mahmood; Khalifah Mahdi Salih; Dhurgham Hameed Hasan
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 3 (2022): Indian Journal of Forensic Medicine and Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i3.18273

Abstract

We report five cases of tri-allelic patterns observed during establishment of genetic fingerprint database for 354individual from Iraqi security forces volunteers. These individuals had been typed by using the PowerPlex®Fusion System for the following 22 autosomal STRs: D3S1358, D1S1656, D2S441, D10S1248, D13S317, Penta E,D16S539, D18S51, D2S1338, CSF1PO, Penta D, TH01, vWA, D21S11, D7S820, D5S818, TPOX, D8S1179, D12S391,D19S433, FGA and D22S1045. All five tri-allelic patterns were observed at the Penta D locus and had the genotype9/11/13, 9.4/13/14, 9/10/11, 7/9/11 and 9/10/14 respectively. All cases belonged to the Type 2 tri-allelic pattern;involve a fairly balanced set of three alleles. Five cases in 354 typed individuals is a frequency for tri-allelic patternsin autosomal STRs of 1.41%.
Co-Authors Dhurgham Hameed Hasan Esam Ghazi Mohammed Salih Hanan Khaleel Mahmood Khalifah Mahdi Salih Majeed Arsheed Sabbah Mohammed Mahdi Al-Zubaidi Shaimaa Abbas Dawood