<![CDATA[Nowadays people worldwide uses several medicinal plants especially for curing urinary lithiasis.Ammivisnagais extensively distributed medicinal plant used for management of numerous diseases including urinarylithiasis.Cymbopogonproximus or called Halfa-bar suggested for use in medicine for the ejection of uretericand renal calculi.Ammivisnagaand Halfa-barfound in Asia and several parts of the world. This study aimedat investigating and comparing both Ammivisnaga and Halfa-barextracts for their antiurolithicactivityusing a mature female rabbit. Forty-two rabbits randomly divided into four groups.Group A negativecontrol, group Bpositive control (chemically induced urolithiasis),group Clike group B but treated withAmmivisnaga extract 5 ml orally twice daily for 2 weeks and group Dlike group B but treated with Proximol(Halfa Bar extract) 5 ml twice daily for 2 weeks also.GC-MS analysis of alcoholic extract of AmmiVisnagarevealed the detection of main alkaloids Khellin, Visnagin, adulicin and enidimine, withothercompoundsinlower quantity. The results show that group of induced urinary lithiasis for 14 days and 21 days showedclear body weight loss, higher consumption of drinking water and increased morning urine excretion. Inaddition to significant increase of blood urea, uric acid, serum creatinine and calcium levels.After 14 daysof treatment with AmmiVisnaga extract and proximol we noticed reversed body weight loss and overcomelow blood urea, serum uric acid, creatinine and calcium. Furthermore,urinary lithiasisgroups showed clearcrystallization compared to the control urine samples, but after 14 days treatment with AmmiVisnaga andproximol extracts, there was nearly clearance of the urine and disappearance of the crystals from the urine.In conclusion, AmmiVisnaga and Proximol are safe and good diuretic herbs causes improvement in the bodyweight, high clearance in urine crystals and amelioration in kidney function compared to untreated group.]]>
