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All Journal Indian Journal of Forensic Medicine & Toxicology
Laith Sami Mehdi
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Public Health

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Alliance of Matrix Metalloproteinase-9 Promoter-1562C/T Polymorphism and Metalloproteinase-9 Saliva Concentration of Iraqi Patients with Chronic Periodontitis Atyaf Lateef Alturfa; Laith Sami Mehdi; Majida Sulaiman Aadai
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17237

Abstract

Matrix metalloproteinases (MMPs) are key enzymes responsible for matrix degradation, derived frompolymorphonuclear leukocytes, during the early stages of periodontitis. There is plenty of evidencefor the role of matrix metalloproteinases in the destructive processes of periodontal disease as a viabletarget in early diagnosis and chemotherapeutic approach. The aim of this study was to determine thelevels of salivary matrix metalloproteinase-9 (MMP-9) in patients with periodontitis and healthycontrols and the role of gene polymorphisms in the aetiology of the disease. Levels of MMP-9 insaliva was determined by enzyme linked immune sorbent assay (ELISA) technique in healthy subjectswithout any periodontal disease (n = 45) and in the patients with diagnosed periodontitis (n = 45).Gene Amplification, gel electrophoresis and genotyping were also carried out on MMP-9 gene. TheMMP-9-1562C/T appeared in three genotypes: CC, CT and TT, allele specific gene polymorphism wasamplified by PCR technique. The distribution of different genotypes in patients and controls for each ofMMP-9-1562C/T polymorphism was in a good accordance with Hardy-Weinberg equilibrium (HWE).Genotypes in both dominant and recessive models were non-significantly associated with periodontitis.Significantly higher salivary MMP-9 was observed in cases of periodontitis compared to healthy adults(p = 0.043). Salivary MMP-9 may serve as a biomarker of periodontal disease monitoring and aid inthe early detection of periodontitis.
Estimation of HsCRP and Cardiac Troponin I in Ischemic Heart Disease Iraqi Patients Majida Sulaiman Aadai; Mayada Noori Iqbal; Laith Sami Mehdi; Nahlah Ghanim Abdul Majeed
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.16258

Abstract

The present study is an attempt to investigate the changes in serum cardiac troponin (cTn) and HighsensitivityC-reactive protein (HsCRP) markers levels in Iraqi ischemic heart disease (IHD) patientsincluding stable angina (SA), unstable angina (UA) and myocardial infarction (MI) compared to the healthycontrols (HC), and to evaluate the importance of the HsCRP between these diseases combination groupsfrom the dignostic point of view, in addition to find a significant correlation between HsCRP level and someIHD risk factors. The IHD’s mortality surpass that of every major disease, so it is important that to getsuch research especially among Iraqi patients. IHD is defined as blood flow reduction to the heart muscledue to build-up of fatty strips (plaque) in the coronary arteries, it exists when the coronary blood flowbecomes incapable of both delivering sufficient oxygen (O2) to the myocardium and taking away the carbondioxide (CO2) from the cells. Collecting the blood samples from one hundred thirty IHD patients (during theperiod from October 2020 to February 2021) with ages ranged (30-80) years, of both genders, investigatedfor HsCRP by enzyme linked immune sorbent assay (ELISA) technique and cardiac Troponin (cTn I) byimmunochromography method. This study observed that the HsCRP marker is a reliable diagnostic indicatorin both MI and UA groups (but not in SA patients), and in all diseases combination groups, and that therewas significant correlations between each of the triglyceride level and the hypertension, and the HsCRPmarker level, only in the MI group, but not in SA and UA patients.
Co-Authors Atyaf Lateef Alturfa Majida Sulaiman Aadai Mayada Noori Iqbal Nahlah Ghanim Abdul Majeed