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All Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Majalah Farmaseutik Media Ilmu Kesehatan
Setiawati, Margarita Krishna
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Health Professions Medicine & Pharmacology Nursing Public Health

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Pengaruh Intervensi Apoteker terhadap Tingkat Bahaya Drug-Related Problems pada Pasien Geriatrik Rawat Inap Margarita Krishna Setiawati; Nanang Munif Yasin; I Dewa Putu Pramantara
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 11, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.66776

Abstract

Geriatric patients are at high risk of Drug-Related Problems (DRPs) associated with multimorbidity, physiologic changes, and pharmacologic alterations, that caused by the aging process. The pharmacist plays an important role in optimizing the effectiveness and safety of the patient’s drug therapies. This study aims to know the effect of pharmacist intervention in reducing the harmful levels of DRPs and to know the factors associated with the reduction of DRPs harm level in hospitalized geriatric patients. This research uses quasi-experimental study with a one-group pretest and posttest design. This research was conducted in Panti Rapih Hospital between March-April 2021, with patients’ inclusion criteria of ≥ 60 years old, with internal diseases cases, and identified DRPs in the therapy. The exclusion patient criteria are hospitalized in the intensive unit and Covid-19 ward. A pharmacist reviewed patient drug therapy, identified and solved DRPs. The harm level of DRPs was compared before and after pharmacist interventions. The harm level of DRPs was determined through professional adjustment according to The Harm Associated with Medication Error Classification tools, then analyzed using Wilcoxon test with a level of confidence 95%. Factors of age, the number of drugs received by the patient, comorbidities, and acceptance of the intervention were investigated for their effect on reducing the harm level of DRPs using a multivariate logistic regression test. A total of the research subject were 28 inpatients, with 47 DRPs identified. The most frequent DRPs were adverse drug reactions  (27,66%). Among all interventions, 77,36% of them were accepted with full implementation. The pharmacist intervention resulted in a significant reduction in the harm level of both potential and actual DRPs (p < 0,05). A factor of the number of drugs received by patients and acceptance of pharmacist intervention was associated with the reduction of the harm level of DRPs (p < 0,05). This study shows that multidisciplinary collaboration is needed in the care of geriatric patients.
Faktor Prediktif Signifikansi Dampak Klinik Intervensi Apoteker pada Pasien Geriatrik Rawat Inap Margarita Krishna Setiawati; I Dewa Putu Pramantara
Majalah Farmaseutik Vol 18, No 4 (2022): in press
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v18i4.68426

Abstract

Pasien geriatrik mengalami perubahan fisiologik, farmakokinetika, dan farmakodinamika. Hal ini menjadi penyebab terjadinya Drug-Related Problems (DRPs) pada geriatrik. Apoteker berperan penting dalam mengoptimalkan efektivitas dan keamanan terapi obat pasien khususnya geriatrik, yaitu dengan mencegah dan mengatasi DRPs. Penelitian ini bertujuan mengetahui faktor prediktif (komorbiditas, jumlah obat, Length of stay, dan usia) signifikansi dampak klinik intervensi Apoteker pada pasien geriatrik rawat inap. Dengan diketahuinya faktor prediktif ini dapat membantu Apoteker untuk dapat melakukan prioritas dalam pemantauan terapi obat pasien. Penelitian ini merupakan penelitian quasi experimental without control group. Penelitian dilakukan pada pasien geriatrik rawat inap di Rumah Sakit Panti Rapih periode Maret - April 2021, dengan kriteria inklusi pasien usia ≥ 60 tahun, merupakan kasus penyakit dalam, dan teridentifikasi DRPs. Kriteria eksklusi pasien dirawat di ruang perawatan Covid-19 dan ruang intensif. Apoteker melakukan pemantauan terapi obat pasien, mengidentifikasi DRPs, dan memberikan intervensi atasnya. Intervensi yang diberikan Apoteker, dinilai signifikansi dampak kliniknya. Signifikansi dampak klinik intervensi Apoteker ditentukan melalui professional adjustment berdasarkan tools yaitu Assessment the potential impact of the pharmacist’s recommendation on patient care. Penelitian ini menggunakan analisis univariat dan multivariat. Pasien yang memenuhi kriteria inklusi dan eksklusi berjumlah 28 orang, dengan total 47 DRPs dan jumlah intervensi sebanyak 53. Signifikansi intervensi yang terbanyak adalah kategori significant yaitu sebanyak 50,94%. Faktor prediktif (komorbiditas, jumlah obat, Length of stay, dan usia) tidak menunjukkan hubungan yang signifikan terhadap signifikansi dampak klinik intervensi Apoteker.
Relationship between level of adherence with antihypertensive medication use and quality of life of hypertensive patients at Umbulharjo II community health center Padmasari, Siwi; Laim, Lidya Adriana Clarita; Setiawati, Margarita Krishna
MEDIA ILMU KESEHATAN Vol 13 No 3 (2024): Media Ilmu Kesehatan
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/mik.v13i3.1388

Abstract

Background: Hypertension is one of the most common non-communicable diseases in Indonesia. Compliance with the use of antihypertensive medications is a major factor in the implementation of hypertension, which can affect a hypertensive patient's quality of lifeObjective: The aim of this study is to find out the relationship between compliance with antihypertensive drug use and the quality of life of hypertensive patients in Puskesmas Umbulharjo II.Methods: The study uses a cross-sectional analytical observational design with data collection on compliance level with MMAS-8 questionnaires and quality of life with the SF-36 questionnaire. The sampling technique purposively sampled 202 patients. Data analysis was done with the Spearman test.Results: The results of the study showed that the majority of patients aged >60 years (67.33%), female sex (65.84%), last high school education (42.08%), work as a householder (45.54%), have concomitant diseases (72.28%), suffer from hypertension for 1–5 years (43.77%), receive single therapy (92.57%), and the most frequently used type of antihypertensive drug is amlodipine (90.10%). The rate of compliance with the use of antihypertensive drugs is in the moderate category (37.62%), and the quality of life is in the high category (73.76%).Conclusion: There is a relationship between the level of compliance with antihypertensive medication use and the quality of life of hypertensive patients in Puskesmas Umbulharjo II (p-value=0,001).
Co-Authors I Dewa Putu Pramantara I Dewa Putu Pramantara I Dewa Putu Pramantara Laim, Lidya Adriana Clarita Nanang Munif Yasin Nanang Munif Yasin Padmasari, Siwi