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All Journal Jurnal Ilmu Dasar Medical and Health Science Journal
Shodikin, M. Ali
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Control & Systems Engineering Health Professions Mathematics Social Sciences

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THE PROFILE AND PATIENT ACUTE HEPATITIS CHILDREN OUTPUT IN DR SOEBANDI JEMBER HOSPITAL Adita Rini, Ika Wahyu; Shodikin, M. Ali
Jurnal Ilmu Kesehatan dan Kesehatan Vol 5 No 2 (2021): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v5i2.2019

Abstract

Background: Indonesia is an endemic area for Hepatitis akut. District of Jember determines the status of extraordinary event Hepatitis akut at the end of 2019. The purpose of this study was the profile and patient acute hepatitis children output in dr Soebandi Jember Hospital in December 2019 until January 2020. Methods: This study was retrospective descriptive. The material was taken of the medical records Hepatitis akut patient at the pediatric departement of the dr. Soebandi Hospital in Jember. Results: In this study, patients most often occurred in male, age ranged between 7 – 14 years, and lived on the villages. The most common of clinical manifestation are anorexia, jaundice, fever, hepatomegaly, dark urine, vomiting and abdominal pain. The result of laboratory examination showed that Hepatitis acut patient had elevated of SGOT , SGPT, direct and total bilirubin. Conclusions: The combination of curcuma with SNMC (Stronger Neo-Minophagen C)  reductly significant SGOT and SGPT serum levels (p < 0,001).  
The 32 kDa Outer Membrane Proteins of Klebsiella pneumoniae Acts as A Bacterial Adhesin Agustina, Dini; Shodikin, M. Ali; Nugraha, Bima Setia Sandya; Mufida, Diana Chusna; Suswati, Enny; Hermansyah, Bagus
Jurnal ILMU DASAR Vol 23 No 2 (2022)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jid.v23i2.25435

Abstract

Klebsiella pneumoniae is a bacterium that often causes infection in the human body. At present K. pneumoniae can resist some of the antibiotics it has associated with modification of one of the virulence factors possessed by K. pneumoniae. One virulence factor of K. pneumoniae as pathogen bacteria is Outer Membrane Protein (OMP). The study of adhesin factors in K. pneumoniae involving hemagglutinin and adhesin proteins that have been found in the OMP 20 kDa and 40 kDa, but there is still no research that discusses the role of 32 kDa OMP as a hemagglutinin protein and adhesin. The purpose of this study is to determine the role of 32 kDa outer membrane of K. pneumoniae as hemagglutinin and adhesin proteins. After isolation of Outer Member Protein (OMP) from the K. pneumoniae, which then carried out a hemagglutination test using mice erythrocyte cells and adhesion test using mice enterocyte cells. The results of the hemagglutination test using mice erythrocyte cells obtained the highest hemagglutination titer for the molecular weight of 32 kDa in titers 1/4. The adhesion index with dilution titer has a significant relationship, with a conversion coefficient of 0,813 which means the dilution titer with the OMP adhesion index has a strong relationship with the direction of a positive relationship. The regression test results obtained an R-value of 0,813 which shows a strong relationship, while the R2 value is 66.1%. Conclusion in this study is 32 kDa outer membrane proteins of K. pneumoniae acts as a bacterial adhesin.
Co-Authors Adita Rini, Ika Wahyu Bagus Hermansyah Diana Chusna Mufida Dini Agustina ENNY SUSWATI Nugraha, Bima Setia Sandya