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All Journal Nusantara Medical Science Journal SCRIPTA SCORE Scientific Medical Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Suciangto, William
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Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Effect of Probiotics as Therapeutical and Preventive Modality for Atopic Dermatitis; Lessons from Clinical Trials SUCIANGTO, WILLIAM; NASRUM, NADA INDIRA RAMADHANI
Nusantara Medical Science Journal Volume 9 Issue 1, January - June 2024
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.20734

Abstract

Introduction:   Atopic dermatitis is a chronic relapsing inflammatory skin disease that can significantly impact patients' quality of life. Current therapy for atopic dermatitis is corticosteroids, calcineurin inhibitors, and immunosuppressants, but the recurrence of this disease is still reported, and their long-term use is vicious due to their immunosuppressive side effects; the need to discover a new modality that can be used as a therapeutical and preventive modality for atopic dermatitis. Probiotics have been well known for decades due to their various biological activities, including anti-inflammatory and immune-regulatory activity, that have many potential benefits for some skin diseases, including atopic dermatitis. Method:     The method consisted of analyzing and evaluating relevant journal literature published within the past ten years. Result: Several clinical trials have proven the effectiveness of various species of Lactobacilli in improving clinical outcomes for children with atopic dermatitis.  Clinical improvement of atopic dermatitis in children can be achieved not only through the administration of a single probiotic but also by combining different probiotic species. Conclusions:  Based on those studies, probiotics are the potential therapeutical and preventive modality for atopic dermatitis and its primary possible mechanism.
Clinical and Endoscopic Improvement of Inflammatory Bowel Disease with Curcumin Therapy: Experiences from Clinical Studies Suciangto, William; Syahrir, Munaiva
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 23, No 3 (2022): VOLUME 23, NUMBER 3, December 2022
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2332022240-248

Abstract

Inflammatory bowel disease, including Crohn’s disease and ulcerative colitis, is a chronic inflammatory condition of the intestine and one of etiological factor for colon cancer development. Incidences of inflammatory bowel disease is still high around the world, even with current therapy, emerging the need for innovational approach to increase the achievement of disease improvement and remission. Curcumin is a natural compound derived from Curcuma longa and has been well known with its anti-inflammatory properties which is possible to be beneficial for inflammatory bowel disease. This review aims to provide clinical evidences of effectively and safety profile of curcumin in treating inflammatory bowel disease, both Crohn’s disease and ulcerative colitis, and viewing the future prospect of curcumin to be an effective adjuvant therapy to prevent the relapse of inflammatory bowel disease. 
Potency of Carica papaya Leaf Extract as Thrombocytopenia Therapy for Dengue Hemorrhagic Fever: A Systematic Review of Randomized Control Trials Firmansyah Sabir, Muhammad Farid; Suciangto, William; Rahmani, Muhammad Zaki; Eka Lestari, Anfauziyah; Mubin, Risna Halim
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 2 (2023): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i2.9541

Abstract

Background: Dengue fever is a common disease in tropical countries. According to the data from the Indonesia Ministry of Health, there were 71.633 Dengue Haemorrhagic Fever (DHF) cases reported in Indonesia, with approximately 459 people dying from the disease. Thrombocytopenia is the most common clinical feature of DHF and often causes serious complications if not treatedproperly. Several studies have analyzed the potency of Carica papaya leaf which has been proven asan effective therapy for thrombocytopenia. Objectives: This systematic review aims to discover the potency of Carica papaya leaf extract as a therapy for thrombocytopenia. Method: Literature was searched by using keywords in accordance with the topic, then filtered according to the inclusion criteria that had been determined according to the PRISMA rules. Publication bias in this reviewwas conducted subjectively using the Revman 5.4 software. Results: From 138 studies, it wasfound that screening was carried out based on inclusion criteria, including a randomized controlled trial study in humans with a population of dengue fever patients and received the intervention of papaya leaf extract so that 6 studies were included in the inclusion study, which was then carried out by qualitative synthesis from the study. Based on the results of the qualitative analysis, it wasfound that there was a faster and more significant improvement in the platelet count between the intervention group compared to the control group in the 6 studies. Conclusion: Carica papaya leaf extract has potential as a thrombocytopenia therapy in dengue fever patients.
Co-Authors Eka Lestari, Anfauziyah Firmansyah Sabir, Muhammad Farid Mubin, Risna Halim Nasrum, Nada Indira Ramadhani Rahmani, Muhammad Zaki Syahrir, Munaiva