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All Journal Majalah Kesehatan FKUB Journal of Psychiatry Psychology and Behavioral Research (JPPBR)
Fadriyana, Aulia Putri
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Humanities Education Medicine & Pharmacology Nursing Public Health

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EFEK SAMPING KEMOTERAPI BERBASIS KARBOPLATIN TERHADAP FUNGSI GINJAL PADA PASIEN KANKER GINEKOLOGI Hermanto, Djoko Heri; Mayangsari, Elly; Fadriyana, Aulia Putri
Majalah Kesehatan FKUB Vol 8, No 3 (2021): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2021.008.03.3

Abstract

Karboplatin merupakan regimen platinum terapi lini pertama pada pengobatan kanker ginekologi. Karboplatin analog dengan cisplatin, tetapi lebih stabil dan memiliki lebih sedikit efek samping. Namun, pemberian karboplatin dalam jangka panjang dapat meningkatkan akumulasinya pada tubuh sehingga meningkatkan efek samping, salah satunya pada ginjal. Tujuan penelitian ini untuk mengetahui efek samping kemoterapi berbasis karboplatin terhadap fungsi ginjal pada pasien kanker ginekologi di RSUD Dr. Saiful Anwar Malang, dengan parameter penurunan laju filtrasi glomerulus (LFG) dan peningkatan kadar blood urea nitrogen (BUN). Desain penelitian adalah analitik observasional cross-sectional dengan mengumpulkan data rekam medis dari pasien kanker ginekologi. Jumlah subjek diperoleh 45 pasien yang memenuhi kriteria inklusi dan eksklusi. Karakteristik subjek penelitian menunjukkan bahwa sebagian besar pasien dalam rentang usia 40-49 dan 50-59 tahun masing-masing sebanyak 15 pasien (33,33%). Berdasarkan hasil uji t berpasangan diketahui bahwa tidak ada penurunan yang signifikan pada LFG pre dan post kemoterapi (p = 0,254) sedangkan berdasarkan hasil uji Wilcoxon didapatkan tidak ada peningkatan yang signifikan pada kadar BUN pre dan post kemoterapi (p = 0,498). Dari hasil penelitian, dapat disimpulkan bahwa tidak terdapat penurunan laju filtrasi glomerulus (LFG) dan peningkatan kadar BUN pada pasien kanker ginekologi yang mendapat kemoterapi berbasis karboplatin sebanyak 6 siklus di RSUD Dr. Saiful Anwar Malang. 
ACCEPTANCE AND COMMITMENT THERAPY FOR PARENTS OF CHILDREN WITH INTELLECTUAL DISABILITY Fadriyana, Aulia Putri
Journal of Psychiatry Psychology and Behavioral Research Vol. 6 No. 2 (2025): Mental Health Framework from a Multidisciplinary Perspective
Publisher : Departemen Psikiatri Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jppbr.2025.006.02.4

Abstract

Introduction – Intellectual disability is one of the most common disabilities of children worldwide, and it becomes a stress burden among parents. Acceptance and Commitment Therapy (ACT), which goals to increase valued action and behaviour in the present moment, has been suggested as an alternative approach. This literature review aimed to explore the effect of acceptance and commitment therapy for parents of children with intellectual disability. Methods – The searches of this literature review were conducted in Google Scholar, ScienceDirect, PubMed, and Wiley Library, ranging from 2010 to 2023. The literature search involved articles that focused on the effect of ACT in parents of children with intellectual disability. Results – Four research articles were included. All of the article’s studies are about the use of ACT in parents of children with intellectual disability, but in different interventions and study designs. Discuss – Most parents stated that the struggles of caring for a child with significant behavioural challenges, both emotionally and physically, and the level of isolation they experienced, consequently, was great enough to generate stress. This programme gives a new perspective on their difficulties, enhancing their ability to deal with stress, and enabling parents to maintain their emotional well-being by “getting back on the track” of what parents should be based on their personal values. Conclusion – ACT may play a significant role in helping to improve the psychological well-being of parents with intellectual disability child. However, further investigation with interventions for each group based on precipitating factors is required to evaluate and to predict when the right time is to do this therapy.
Co-Authors Hermanto, Djoko Heri Mayangsari, Elly