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All Journal Jurnal Teknologi Pangan dan Gizi Journal of Tropical Biodiversity and Biotechnology International Journal of Cell and Biomedical Science
Rifai, Fauziah Novita Putri
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Environmental Science Immunology & microbiology Medicine & Pharmacology

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VARIASI IDENTIFIKASI KUALITATIF FORMALIN PADA IKAN TONGKOL (Euthynnus affinis) DI PASAR TRADISIONAL YOGYAKARTA Rifai, Fauziah Novita Putri; Maliza, Rita
Jurnal Teknologi Pangan dan Gizi Vol 20, No 1 (2021)
Publisher : Widya Mandala Surabaya Catholic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jtpg.v20i1.2361

Abstract

Penggunaan pengawet non pangan formalin pada bahan makanan saat ini sudah banyak digunakan. Salah satu cara yang digunakan oleh pedagang ikan dalam proses pengawetan, yaitu dengan menggunakan formalin untuk menghambat terjadinya proses pembusukan dan kemunduran mutu ikan oleh mikroorganisme. Formalin dapat menimbulkan efek jangka pendek dan panjang pada kesehatan. Kandungan formalin pada ikan dapat diidentifikasi dengan uji kualitatif dan uji kuantitatif. Metode uji kualitatif formalin yang memiliki tingkat keakuratan tinggi dan spesifik pada sampel ikan segar saat ini belum dilaporkan. Oleh karena itu dilakukan penelitian yang bertujuan untuk menentukan metode kualitatif formalin yang paling akurat dan sesuai untuk identifikasi formalin pada sampel ikan tongkol. Penelitian ini menggunakan 5 metode uji kualitatif diantaranya asam kromatofat (K10H8O8S2), Tollens, KMnO4 0,1 N, Schiff, dan Fehling pada sampel ikan tongkol yang dijual dibeberapa Pasar Tradisional Yogyakarta. Berdasarkan hasil penelitian, tingkat sensitivitas dari 5 metode uji kualitatif formalin yang digunakan pada 15 sampel ikan tongkol yang paling tinggi adalah metode pereaksi Schiff.
Hesperitin Synergistically Promotes the Senescence Induction of Pentagamavunone-1 in Luminal Breast Cancer Cells, T47D Rifai, Fauziah Novita Putri; Hanifa, Mila; Zulfin, Ummi Maryam; Ikawati, Muthi; Meiyanto, Edy
Journal of Tropical Biodiversity and Biotechnology Vol 9, No 1 (2024): March
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jtbb.88238

Abstract

Pentagamavunone-1 (PGV-1), a curcumin analog, is a promising anticancer candidate for several cancers that have been proven in vitro and in vivo. However, the efficacy of PGV-1 against breast cancer is subject to improvement to achieve a more suitable application. Here we propose hesperitin, a citrus flavonoid, to increase the anticancer potency of PGV-1 in luminal breast cancer cells. We use the T47D cell as the model to investigate the effect of co-administration of PGV-1 and hesperitin on cell cycle block, apoptosis modulation, and senescence phenomena. PGV-1 and hesperitin showed strong and weak cytotoxicity with an IC50 value of 2 µM and 100 µM, respectively. The co-treatment of PGV-1 and hesperitin resulted in strong synergistic effects with combination index (CI) value of ≤ 0.2. This combination caused apoptosis in correlation with cell cycle disruption in G2/M phase at 48 h. In particular, PGV-1 and hesperitin combination increased the incidence of cellular senescence significantly higher than the single treatment. Despite its senescence potentiation, hesperitin did not induce senescence in normal cells. Taken together, hesperitin may increase the anticancer potency of PGV-1 by modulating cell cycle arrest and apoptosis via the senescence mechanism. 
Cooperative Impact of Curcuma longa and Phyllanthus niruri Extracts on Cytotoxicity in HCT-116 Cells Ibrahim, Sugeng; Hidayah, Nurul; Rifai, Fauziah Novita Putri; Ginanto, Dede
International Journal of Cell and Biomedical Science Vol 2 No 5 (2023)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v2i5.36

Abstract

Background: The combination of herbal extracts has the potential to enhance cytotoxic effects against cancer cells. This study explores the combined cytotoxic effects of Curcuma longa and Phyllanthus niruri extracts on HCT-116 colorectal cancer cells. Objective: To assess the cytotoxic effects of Curcuma longa and Phyllanthus niruri extracts when used in combination and to determine the most effective ratio for inhibiting HCT-116 cell growth. Methods: HCT-116 cells were treated for 24 hours with varying concentrations of Curcuma longa and Phyllanthus niruri extracts based on the IC50 values of each extract administered individually. The concentrations for Phyllanthus niruri were 164 µg/mL (one part), 82 µg/mL (half part), and 41 µg/mL (quarter part), while for Curcuma longa the concentrations were 47 µg/mL (one part), 24 µg/mL (half part), and 12 µg/mL (quarter part). Cytotoxicity was assessed using the MTT assay. Results: The combination of Phyllanthus niruri and Curcuma longa extracts demonstrated varied cytotoxic effects. The most effective combination was identified as Phyllanthus niruri to Curcuma longa ratio of 1:0.25, resulting in a 13.5% cell viability rate. Interaction studies using the Chou-Talalay method indicated that the combination index (CI) revealed the most synergistic effect at a ratio of 0.25:0.50. Conclusion: The study identifies that the combination of Phyllanthus niruri and Curcuma longa extracts exhibits synergistic cytotoxic effects on HCT-116 cells, with the optimal combination showing significant inhibition of cell growth. These findings support further investigation into the synergistic potential of these extracts for colorectal cancer therapy.
Co-Authors Edy Meiyanto Ginanto, Dede Hanifa, Mila Ibrahim, Sugeng Maliza, Rita Muthi Ikawati NURUL HIDAYAH Zulfin, Ummi Maryam