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Kusumandari, Kusumandari
Department Of Physics, Faculty Of Mathematics And Natural Sciences, Universitas Sebelas Maret, Jl. Ir. Sutami 36A Kentingan Surakarta 57126
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Materials Science & Nanotechnology Physics Social Sciences Other

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Journal : Journal of Physics and Its Applications

 1 
Analysis of Dose Distribution Alpha and Secondary Particles in Therapy Alpha for Glioblastoma Cancer Using MCNP6 Software Agustina, Sheila; Suharyana, Suharyana; Kusumandari, Kusumandari; Arianto, Fajar
Journal of Physics and Its Applications Vol 7, No 4 (2025): November 2025
Publisher : Diponegoro University Semarang Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jpa.v7i4.25893

Abstract

The alpha therapy modeling was performed for the treatment of glioblastoma brain cancer using MCNP6 software. The simulation used a head and neck phantom geometry, with a spherical shape of the radiation direction of the cancer cells with a radius of one cm divided into 27 targets. One radiation source is directed to each target center of the cancer cells with five energy variations, namely (430, 425, 415, 410, and 400) MeV. The simulation results are in the form of a distribution of absorbed doses in all targets and healthy cells around them. The simulation results show an average dose distribution of (1.2902 ± 0.0024) 10-11 Gy/alpha with an isodose level of 69.75%. The healthy organ that receives the largest dose and secondary particle distribution after cancer cells is the brain, with an accumulative dose of (1.7446 ± 0.0033) 10-15 Gy/alpha. The dose distribution on cancer cells shows that the irradiation time to kill glioblastoma cancer cells is (1456±0.14) seconds with an alpha current of 1 nA.
Co-Authors Abdurrahman, Ahmad Faruq Agus Supriyanto Agustina, Sheila Amalia Puji Winarni Antik Erlina Antik Erlina Anwar, Fuad Aprilia, Ayu Ari Handono Ramelan Budi Purnama Budi Purnama Fahru Nurosyid Fajar Arianto Friska Juliana Hutauruk Ida Setiarini Ika Uswatun Hasanah Kamsul Abraha Mohtar Yunianto Mohtar Yunianto, Mohtar Mudasir Mudasir Nor Shalina Saputri Pusaka, Semerdanta Risa Suryana Sehati, Sehati - Suharyana Suharyana Teguh Endah Saraswati Teguh Endah Saraswati Ulfa, Maria Utari Utari Utari Utari Wijayanti, Siti Yofentina Iriani Yofentina Iriani Zahar, Intan