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All Journal MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Folia Medica Indonesiana
Papalois, Apostolos
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The acute effect of erythropoietin on glucose levels during ischemia reperfusion injury in rats Tsompos, Constantinos; Panoulis, Constantinos; Toutouzas, Konstantinos; Zografos, George; Papalois, Apostolos
Folia Medica Indonesiana Vol. 52, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

The aim of this experimental study was to examine the effect of erythropoietin on rat model and particularly in an ischemia reperfusion (HR) protocol. The effect of that molecule was studied biochemically using blood mean glucose (Gl) levels. Materials and methods: 40 rats of mean weight 247.7 g were used in the study. Gl levels were measured at 60 min (groups A and C) and at 120 min (groups B and D) of reperfusion. Erythropoietin was administered only in groups C and D. Results were that Epo administration non-significantly increased the gl levels by 5.59% +6.46% (p=0.3208). Reperfusion time non-significantly increased the gl levels by 5.63%+6.45% (p=0.4098). However, erythropoietin administration and reperfusion time together produced a non significant combined effect in increasing the gl levels by 4.94%+3.81% (p= 0.1892). Conclusions: Results of this study indicate that erythropoietin administration, reperfusion time, or their interaction non-significantly increase the blood glucose levels in short-term. Opposite bibliographic data are considered more reliable, until a greater sample provide clearer results.
Histologic comparison of the uterine pathologic effects of erythropoietin and U-74389G Tsompos, Constantinos; Panoulis, Constantinos; Zografos, Constantinos; Zografos, GeorgeC; Papalois, Apostolos
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 13, No 1 (2026): FEBRUARY
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.13.1.2026.%p

Abstract

Background: This manuscript compared the effects at uterine pathology (UP), after processing with either the drug erythropoietin hormone (Epo), or the lazaroid antioxidant agent (L) one U-74389G. This comparison was provided by outcomes of 2 preceding branches.Objective: Both studies estimated the effect, after each drug use in a planned uterine ischemia -  reperfusion (UIR) mice experimental setting.Methods: Both principal experiment timepoints, the uterine histology was evaluated were the min 60th after reperfusion (A, C, E groups) and also the min 120th after reperfusion (B, D, F groups). Along, A & B groups were placebo, C & D groups were processed by Epo and E & F groups after the L process.Results: The one study-branch of Epo has presented a hardly significant recessing potency for the total UP within the “lesion-free” grade alteration by -0.0916667 [-0.1907629 - 0.0074296] (p-values = 0.0583). However, the other study-branch of U-74389G presented a respective non-significant accentuation of the total UP within the “lesion-free” grade alteration by 0.2229748 [-0.1376592 - 0.5836089] (p-value = 0.4940). Both branch studies got co-evaluated as they belong to a common experiment. Their outcome was that Epo seems to ameliorate the UP status, whereas L seems to deteriorate it; however, their discrepancy seems to be non-significant (p-value = 0.0677).Conclusion: There is a slight non-significant superiority of Epo than L in UIR pathology restoration (p-value = 0.0677), possibly useful in several clinical situations. 
Co-Authors Panoulis, Constantinos Toutouzas, Konstantinos Tsompos, Constantinos Zografos, Constantinos Zografos, George Zografos, GeorgeC