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All Journal INDONESIAN JOURNAL OF PHARMACY
Zendrato, Ridho Nugroho
Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta
Medicine & Pharmacology

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Synthesis of diacetyl gamavuton-0 using acetyl chloride as an acylating agent Margono, Supardjan Amir; Zendrato, Ridho Nugroho
Indonesian Journal of Pharmacy Vol 17 No 1, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.749 KB) | DOI: 10.14499/indonesianjpharm0iss0pp25-31

Abstract

Gamavuton-0 (GVT-0) is a curcumin-like compound, which is more stable than curcumin and still has an antioxidant property. The synthesis of diacetyl gamavuton-0 (diAcGVT-0) yielding an acetylation product that is more lipophile than GVT-0. The synthesis of diAcGVT-0 has been done by reacting GVT-0 and acetyl chloride as an acylating agent and tertiary amines as primary bases. DiAcGVT-0 was formed as the major product of synthesis but the product was not pure. Structure elucidation using UV-Vis, IR, 1H NMR and MS spectra showed that the main product was diAcGVT-0.Key words : diacetyl gamavuton-0, acetyl chloride, acylating agent, lipophile
Co-Authors Margono, Supardjan Amir