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Rianti, Andrih
Department of Chemical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada. Yogyakarta, Indonesia.
Medicine & Pharmacology

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Visible spectrophotometric determination of Cefadroxil using ethyl acetoacetate and formaldehyde reagents Susidarti, Ratna Asmah; Rianti, Andrih; Martono, Sudibyo
Indonesian Journal of Pharmacy Vol 19 No 1, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.341 KB) | DOI: 10.14499/indonesianjpharm0iss0pp41-47

Abstract

Visible spectrophotometric method can be used to determine cefadroxil in the pharmaceutical dosage form. The reaction of cefadroxil with the condensation product of 2 mol ethyl acetoacetate and 1 mol formaldehyde in acidic condition (pH 3,5) at 45°C for 20 minutes yielded yellow product giving absorption at 367 nm. The concentration of Cefadroxil was calculated by using standard curve Y = 1.6063 X + 0.1634, r = 0.9932, p = 0,001 and Vxo = 9,7%. Determination of cefadroxil capsule ”X” (562.4 mg/capsule) showed that the concentration of cefadroxil observed is 490.5 mg/capsule (CV = 0.89%) and recovery value is 102.88% (CV = 0.67%). Key words: visible spectrophotometry, Cefadroxil, ethyl acetoacetate, formaldehyde
Co-Authors Martono, Sudibyo Ratna Asmah Susidarti