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All Journal INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Indonesian Journal of Chemistry Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat
Christofori Maria Ratna Rini Nastiti
Faculty Of Pharmacy, Sanata Dharma University, Yogyakarta
Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Medicine & Pharmacology Social Sciences Other

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Journal : INDONESIAN JOURNAL OF PHARMACY

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Assay method validation of triamcinolone acetonide (TA) to support the investigation of TA-loaded nanoparticles Nastiti, Christofori Maria Ratna Rini
Indonesian Journal of Pharmacy Vol 20 No 4, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.127 KB) | DOI: 10.14499/indonesianjpharm0iss0pp178-184

Abstract

The aim of this study was to develop the valid analytical method which used for the assay of triamcinolone acetonide (TA) in the investigation of TA-loaded nanoparticle formulations. High Performance Liquid Chromatography (HPLC) method was applied in this study by using an Econosil column, C18 10 'm, 250 x 4.6 mm (Alltech Associates Inc, PA, USA) as the stationary phase. The mobile phase consisted of a composition of acetonitrile (ACN) and 20mM phosphate buffer solution (pH 4.2) in the proportion of 50:50 v/v. The HPLC assay of TA was validated for selectivity, linearity, precision, recovery (accuracy), sensitivity and stability of TA during the assay. Results showed that the concentration of TA in the samples can be determined against the standard in the concentration range of calibration curve. The system precision and level of recovery were considered to be acceptable, and the method was selective and sensitive.Key words: triamcinolone acetonide, assay, validation
Co-Authors Christine Patramurti Florentinus Dika Octa Riswanto Gani, Michael Raharja Michelina, Ellisia Triwulandari, Erna Wijayanti, Fabiola Rani