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All Journal Jurnal Farmasi Sains dan Komunitas Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Sehati
Gani, Michael Raharja
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Agriculture, Biological Sciences & Forestry Humanities Chemistry Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Medicine & Pharmacology Social Sciences Other

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EDUKASI PEMBERIAN GIZI SEIMBANG UNTUK MENCEGAH STUNTING DI KECAMATAN WONOSARI, DAERAH ISTIMEWA YOGYAKARTA Putri, Dina Christin Ayuning; Yuliani, Sri Hartati; Gani, Michael Raharja; Adi, Antonius Iswara; Tasik, Sulistiana; Ani, Ni Wayan; Elliora, Greata; Chusien, Adhita Wicaksaneng Naya Brena; Lewier, Bryan Melianus Agustinus
Jurnal Pengabdian Masyarakat Sehati Vol. 3 No. 2 (2024): Desember
Publisher : Politeknik Medica Farma Husada Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33651/jpms.v3i2.683

Abstract

Angka stunting di Kecamatan Wonosari Daerah Istimewa Yogyakarta cukup tinggi. Upaya-upaya perlu dilakukan untuk menurunkan angka stunting hinga mencapai target yang ditetapkan pemerintah (14%). Kegiatan ini bertujuan untuk meningkatkan pengetahuan orang tua mengenai pola hidup sehat dan pemberian gizi seimbang bagi anak, untuk mencegah stunting. Kegiatan berupa penyuluhan dilakukan terhadap orangtua yang anaknya terindikasi stunting atau hampir stunting di wilayah Kecamatan Wonosari. Evaluasi dilakukan dengan wawancara dan pengisian kuesioner. Kegiatan diikuti oleh 38 orang tua yang bersedia hadir memenuhi undangan. Pengetahuan peserta tentang pola hidup sehat dan pemberian gizi seimbang sangat baik, yang ditunjukkan dengan (pengisian kuesioner) nilai rerata + simpangan baku sebesar 87,91 + 0,69.
PENINGKATAN PENGETAHUAN TENTANG PENYALAHGUNAAN DAN PENGGUNASALAHAN OBAT DI KALANGAN PELAJAR SEKOLAH MENENGAH DI YOGYAKARTA Lestari, Agatha Budi Susiana; Gani, Michael Raharja; Christasani, Putu Dyana
ABDIMAS ALTRUIS: Jurnal Pengabdian Kepada Masyarakat Vol 7, No 2 (2024): Oktober 2024
Publisher : Universitas Sanata Dharma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/aa.v7i2.8172

Abstract

Drug abuse and misuse among teenagers have been on the rise year after year. These teenagers must have a solid knowledge of drug use. Health education is provided to Yogyakarta high school students in order to improve their understanding of drug abuse and misuse. The health education is being held at SMK Kesehatan Pelita Bangsa Yogyakarta with 92 participants. The activities begin with a pre-test, continue with a presentation about drug abuse and misuse, and conclude with a post-test. Most participants are female (82%) and in the twelfth grade (49%). The average pre-test score of 86.41 increases to 91.41 in the average post-test score, indicating an improvement in respondents' knowledge. The activity hopes to teach students how to use drugs rationally, particularly ones widely abused by teenagers.
Nanoemulgel Formulation of Eleutherine palmifolia Onion Bulb Extract and Its Effectiveness in Wound Healing Faisal, Muhammad; Chabib, Lutfi; Dewi, Melynia Sintha; Gani, Michael Raharja; Dwiastuti, Rini
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007454

Abstract

Eleutherine palmifolia onion, an indigenous medicinal plant from Borneo, is empirically applied to treat wound healing. The objective of this study is to formulate its extract and assess its in vivo wound healing activity. Eleutherine palmifolia onion was extracted with a 96% ethanol solvent. The extract of the Dayak onion bulb was then formulated into a nanoemulsion by applying the DOE method of 2-level factorial design. Four nanoemulsion formulations were further analyzed to obtain the optimal formulation. The particle size analysis and % transmittance was performed using a particle size analyzer and an ultraviolet-visible spectrophotometer. Furthermore, the data were analyzed using the Minitab 19 application with the DOE factorial design method. The three nanoemulgel formulations containing 2.5, 5.0, and 7.5% extract were further investigated for wound healing efficacy in rats. The duration of wound closure was analyzed using paired t-tests. The best nanoemulsion formulation was made with 22.5 mL of Tween 80 and 2 mL of isopropyl myristate oil. This produced particles that were 12.13 nm in size and a 99.12% transmittance rate. Wound length measurements were taken daily for 15 days. The statistical test results of p0.05 indicate that the nanoemulgel of the extract has significant activity in wound healing. The optimal nanoemulsion formula is formula A, and the effective dose of Dayak onion extract nanoemulgel is 5% and 7.5% concentrations, with a wound healing time of 13 days.
Evaluation of Diabetic Wound Healing Activity of Novel Quercetin Topical Preparations Nastiti, Christofori Maria Ratna Rini; Michelina, Ellisia; Wijayanti, Fabiola Rani; Gani, Michael Raharja
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007288

Abstract

Diabetic wound needs effective pharmacotherapy in order to accelerate the wound healing process and to prevent further infection. Quercetin (QUE) is one of flavonols which ispotential as an active ingredient for diabetic wound therapy, due to its anti-inflammatory and antioxidant activities.  This current study evidenced wound healing activity of QUE topical preparations on the open wound of diabetic-induced subjects preclinically. The investigation focused on topical administration of QUE nanoemulgels and QUE micellar gels (0.2% w/w of QUE) on groups of diabetic-induced male Wistar rats. The quality of preparations in terms of organoleptic performance, pH, viscosity and spread-ability was physically characterized prior to topical administration to the wound. Punch biopsy (5mm) was applied to create the open wound. The visual observation of wound contraction area (in mm2) was carried out every three days. On the day 12th, after sacrificing the subjects, the wounded tissues were removed, fixed in 10% formalin and prepared for histology examination-hematoxylin and eosin staining. The results showed that the QUE nanoemulgels and QUE micellar gels were relatively comparable onthe physical quality as well as the wound healing activity. Their wound healing activities were remarkably faster compared to the untreated control group and it was showed fromthe histology study that the QUE nanoemulgels and QUE micellar gels successfully accelerate the wound healing process to the proliferation step if it was compared the untreated. In conclusion, QUE nanoemulgels and QUE micellar gels were potential to develop to accelerate the diabetic wound healing process.    
Caffeine and Caffeic Acid as Acetylcholinesterase Inhibitors: In Silico Perspectives Wira Waskitha, Stephanus Satria; Wiranata, Bonifacius Ivan; Mark, Julyus Jason; Krisantia, Herluin Sekar; Kristina, Natalia; Ardine, Glory Ivana; Prasetyo, Chrisologus Ivan; Gani, Michael Raharja; Riswanto, Florentinus Dika Octa; Istyastono, Enade Perdana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009687

Abstract

Alzheimer's disease (AD) has been recognized as a significant issue affecting population health globally and tended to increase over the years. The utilization of natural products for AD treatments has been widely studied, which possibly offers better outcomes with minimum side effects. Coffee consumption has been subjected as a lifestyle propensity, which offers beneficial advantages including reducing the risk of AD. Bioactive natural compounds contained in coffee such as caffeine and caffeic acid have been experimentally proven to be acetylcholinesterase (AChE) inhibitors, a pivotal target enzyme for AD treatments. This research aimed to explore the dynamics interactions of caffeine and caffeic acid in the AChE active site using the in silico approach. In this study, 100 redocking and docking simulations were implemented before the molecular dynamics (MD) simulations. The 55-ns MD simulations of huprine X, caffeine, and caffeic acid were implemented to study the dynamics interactions. Conformational stability, free energies of binding, and interaction hotspots were identified during the simulations. Our findings informed that caffeine interacted in the active site during the simulations, revealing the importance of the imidazole ring in maintaining the interactions. In contrast, caffeic acid interacted longer in the plausible allosteric site, forming ionic, hydrogen bonds, and aromatic interactions.
Co-Authors Adi, Antonius Iswara Agatha Budi Susiana Lestari Ani, Ni Wayan Ardine, Glory Ivana Christofori Maria Ratna Rini Nastiti Chusien, Adhita Wicaksaneng Naya Brena Dewi, Melynia Sintha Dina Christin Ayuning Putri Elliora, Greata Enade Perdana Istyastono Florentinus Dika Octa Riswanto Krisantia, Herluin Sekar Kristina, Natalia Lewier, Bryan Melianus Agustinus Lutfi Chabib, Lutfi Mark, Julyus Jason Michelina, Ellisia Muhammad Faisal Prasetyo, Chrisologus Ivan Putu Dyana Christasani Rini Dwiastuti Sri Hartati Yuliani Tasik, Sulistiana Wijayanti, Fabiola Rani Wira Waskitha, Stephanus Satria Wiranata, Bonifacius Ivan