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Tamat, Swasono R
Pancasila University
Medicine & Pharmacology

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Isolation and Identification of α-Glucosidase Inhibitor From Aspergillus Terreus F38 Munasaroh, Siti; Tamat, Swasono R; Dewi, Rizna Triana
Indonesian Journal of Pharmacy Vol 29 No 2, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1521.514 KB) | DOI: 10.14499/indonesianjpharm29iss2pp74

Abstract

Controlled postprandial glucose level is an important strategy in preventing DM type 2. Inhibitors of α-glucosidase have been postulated to be useful agents in managements of DM type 2. This research aims to isolate and identify of α-glucosidase inhibitor fromAspergillus terreus F38 by liquid fermentation. The mycelium extract of A. terreus F38showed strong activity against α-glucosidase with IC50 value of 9.65 μg/mL. Separation and purification of mycelium ectract yielded compound I (Butyrolactone III). The structure was establish on the basis of spectral analysis, according to the data obtained by NMR and LCMS-MS experiments. Compound I showed potential activity against α-glucosidase with IC50 value of 13.87  μg/mL. Therefore, the metabolites from A. terreus F38 can be used as lead compound to design potent α-glucosidase inhibitory agents.
Co-Authors Dewi, Rizna Triana Munasaroh, Siti