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All Journal INDONESIAN JOURNAL OF PHARMACY
Goswami, Manish
Akal College of Pharmacy and Tecchnical Educaiton, Mastuana Sahib, Sangrur, Punjab, 148001, India
Medicine & Pharmacology

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IN VITRO ABSORPTION STUDY OF CARBAMAZEPINE SOLID DISPERSION USING EVERTED GUT SAC METHOD Thakur, Nishant; Thakral, Sunil; Goswami, Manish; Ghaie, Pankaj; Thakur, Amit; Mangal, Mohit
Indonesian Journal of Pharmacy Vol 24 No 2, 2013
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (340.388 KB) | DOI: 10.14499/indonesianjpharm24iss2pp93-99

Abstract

The oral Bioavailability of BCS (Bio Pharmaceutical Classification System) class II drug with poor solubility and reasonable permeability is limited by drug dissolution. In order to improve the aqueous solubility of the drug and dissolution of thedrug, the solid dispersion was prepared and evaluated for its absorption in intestine using modified everted gut sac method. The solid dispersion of carbamezepine (CBZ) was prepared using polaxomer and guargum by kneading method. The CBZ and CBZSD (Solid Disposisi) shows 2.329% and 3.948% drug absorption, respectively. The data show that solid dispersion increase the absorption of the CBZ in CBZ-SD is more than 70% in comparison to pure CBZ. The increase in CBZ solubility of the SD could be attributed to several factors such as improved wettability, local solubilization, drug particle size reduction and crystalline or, interstitial solid solution reduction. Key words: Everted gut sac method, solid dispersion, absorption, solubility
Co-Authors Ghaie, Pankaj Mangal, Mohit Thakral, Sunil Thakur, Amit Thakur, Nishant