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All Journal INDONESIAN JOURNAL OF PHARMACY
Baluja, Shipra
Department of Chemistry, Saurashtra University, Rajkot-360005, India
Medicine & Pharmacology

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SYNTHESIS AND SCREENING OF SOME AZOMETHINES BEARING METHYL SALICYLATE MOIETY FOR ANTIBACTERIAL ACTIVITIES Baluja, Shipra; Chanda, Sumitra
Indonesian Journal of Pharmacy Vol 27 No 2, 2016
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (731.123 KB) | DOI: 10.14499/indonesianjpharm27iss2pp92

Abstract

In this study, the series of novel azomethines were synthesized from methyl salicylate and their structural determination was done by IR, NMR and mass spectral data. The screening of these synthesized compounds were done against some Gram positive and Gram negative bacteria in DMF and DMSO solvents by agar disc method. It is observed that solvent and compound structure both affect the inhibition. DMF is found to be good solvent in the present study. Amongst all studied compounds, JB-4 showed maximum zone of inhibition against most of the studied bacterial strains while compound JB-2 is least effective. Thus, substitution affects inhibition and methyl salicylate moiety with cinnamaldehyde side chain is most effective. Further, virtual screening of these compounds was done to evaluate molecular properties and bioactive scores of these compounds.Keywords: azomethines, methyl salicylate, antibacterial activity, agar disc method, DMF, DMSO
Co-Authors Sumitra Chanda, Sumitra