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All Journal INDONESIAN JOURNAL OF PHARMACY
Khandpekar, Mahendra
Materials Research Lab, Department of Physics,BirlaCollege
Medicine & Pharmacology

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COMPARATIVE STUDIES ON SYNTHESIS AND STRUCTURE OF OLD AND NEW POLYMORPHS OF DESVENLAFAXINE - AN ANTIDEPRESSANT DRUG Khandpekar, Mahendra
Indonesian Journal of Pharmacy Vol 25 No 1, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (393.606 KB) | DOI: 10.14499/indonesianjpharm25iss1pp25

Abstract

Desvenlafaxine  succinate (pristiq) is an important non-hormonal drug used in the treatment of major depressive disorder and problems associated with menopause.This article summarizes the synthesis and investigation of new polymorphic form of Desmethylvenlafaxine. The new polymorph has been compared with the old polymorph using XRD, DSC, FTIR, SEM and HPLC techniques. Three prominent reflections with higher intensities lying at 20.3, 13.1 and 15.8 have been noted in the XRD measurements for the new polymorph. Higher intensity (XRD) peaks for the new polymorph indicates good crystalline quality. FTIR spectra shows close match between the polymorphs. DSC measurements show enhanced thermal stability for the new polymorph. Higher purity is indicated by the HPLC studies.Key words: desvenlafaxine, polymorphism, structure, crystalline, purity
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