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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Universa Medicina Indonesian Journal of Biomedicine and Clinical Sciences
Sakti Ronggowardhana Brodjonegoro
Divison Of Urology, Department Of Surgery, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Evaluation of oxidative stress levels using glutathione peroxidase (GPx) expression on hyperglycemia-induced rats testis Andreas Pramudito; Sakti Ronggowardhana Brodjonegoro; Ahmad Zulfan; Aria Danurdoro; Didik Setyo Heriyanto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 53, No 4 (2021)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005304202103

Abstract

Diabetes mellitus (DM) is a global health problem with an estimated 422 million cases worldwide. Previous studies reported a correlation between hyperglycemia and oxidative stress‐related male infertility in DM. Glutathione peroxidase (GPx) can cause DNA damage due to oxidative reactions. Therefore, it could be used as potential indicator of antioxidant therapy. The study aimed to evaluate the expression level of GPx on the hyperglycemia-induced rats. This was an experimental case-control study using 27 Wistar rats divided into three groups i.e. hyperglycemia induction for four weeks group, eight weeks group, and a control group with no intervention. Following after induction, total RNA from the rats' testis was extracted, and GPx expression was analyzed using qPCR. Data were analyzed using SPSS, and a p <0.05 was considered significant. The study showed a significantly higher GPx mRNA expression level after hyperglycemia induction in both 4 and 8 weeks groups (16.93 ± 3.32 and 17.62 ± 3.42) compared to control group (9.94 ± 2.91) (p< 0.05). However, no significantly different between the 4 weeks group and 8 weeks group was observed (p >0.05). In conclusion, hyperglycemia increases GPx mRNA expression in rats. It may change the testicular environment's oxidative processes and impairs male reproductive function in the Sertoli cells with no exception.
Delayed diagnosis of bilateral iatrogenic ureteric injury presenting with life-threatening pseudo-acute kidney injury after hysterectomy: a case report Parisudha, Ryuu Damara; Brodjonegoro, Sakti Ronggowardhana; Wiratma , Made Kresna Yudhistira
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.16803

Abstract

Bilateral ureteric injury after pelvic surgeries, particularly hysterectomy, carries a substantial risk of life-threatening conditions such as severe respiratory distress related to pseudo-acute kidney injury (pseudo-AKI) and sepsis due to peritonitis. A 47 y.o. woman presented with anuria 9 d after hysterectomy. She exhibited severe dyspnea requiring intubation, reduced level of consciousness, tachycardia and abdominal distension. Laboratory results revealed rapid increment of urea and creatinine post operatively requiring serial hemodialysis, leukocytosis, hyperkalemia and metabolic acidosis. Imaging identified bilateral hydronephrosis and ascites. An emergency laparotomy was performed, draining 2.7 L of intraperitoneal urine and revealing bilateral distal ureteral ligation with perforations. Subsequent bilateral ureteroneocystostomy was conducted resulting in significant improvements in clinical status as well as normalization of the renal function within 48 hr postoperatively. Bilateral iatrogenic ureteric injury with concurrent urinary ascites is an uncommon but serious complication of gynaecologic surgeries, particularly hysterectomies. This condition significantly increases the risk of renal failure and other life-threatening complications. Delayed diagnosis, as seen in this case, exacerbates these risks. Immediate surgical laparotomy with subsequent ureteroneocystostomy is critical for renal recovery and resolution of urinary ascites. Although rare, bilateral ureteric injury with urinary ascites necessitates prompt recognition and urgent surgical management to prevent severe renal impairment and other life-threatening outcomes. Careful preoperative planning and intraoperative ureteral visualization are essential in reducing the risk of such injuries.
Indwelling ureteral stenting negatively impacts sexual function transiently after endourological procedure among adult male and female patients: a prospective cohort study Kangsaputra, Ferdy Bangun; Budiyono, Nur; Brodjonegoro, Sakti Ronggowardhana
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.276-282

Abstract

BackgroundUreteral stents, which are widely used after endourological procedures, cause adverse effects. However, its potential impact on sexual function remains unclear in patients undergoing ureteral stenting. This study aimed to investigate sexual function in adult male and female patients undergoing endourological procedures involving ureteral stent placement. MethodsWe conducted a prospective cohort study in a double tertiary care hospital setting with 103 selected patients (53 male and 50 female). We used a self-administered questionnaire-based survey, namely the Indonesian version of the 5-item International Index of Erectile Function (IIEF-5) for male patients and the Indonesian Female Sexual Function Index (Indonesian FSFI) for female patients at three different times (pre-stenting, four weeks after stenting, and four weeks after stent removal). A paired t-test or Wilcoxon test was used for data analysis. ResultsIn the male group, significant changes were noted in the four IIEF-5 domains and overall IIEF-5 scores at pre-stenting and four weeks after stenting (p =0.000). The female group showed significant differences for all FSFI domains and overall FSFI scores at pre-stenting and four weeks after stenting (p=0.000). Most patients in both groups recovered sexual function four weeks after stent removal, as indicated by insignificant differences in the overall IIEF-5 and FSFI scores at pre-stenting and four weeks after stent removal. ConclusionUreteral stenting led to significant but transient sexual dysfunction in both groups at four weeks after stenting. In this regard, male and female patients need to receive counselling and attention, that they may experience temporal sexual dysfunction at least for 4 weeks.
Co-Authors Ahmad Zulfan Andreas Pramudito Aria Danurdoro Didik Setyo Heriyanto Kangsaputra, Ferdy Bangun Nur Budiyono, Nur Parisudha, Ryuu Damara Wiratma , Made Kresna Yudhistira