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All Journal Jurnal Mahasiswa Farmasi Fakultas Kedokteran dan Ilmu Kesehatan UNTAN MABIS: Manajemen dan Bisnis
Michael .
Fakultas Kedokteran, Universitas Kristen Maranatha
Economics, Econometrics & Finance Health Professions Medicine & Pharmacology Social Sciences

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PENGARUH EKSTRAK METANOL DAUN KESUM (Polygonum minus Huds.) TERHADAP PENINGKATAN KADAR KREATININ DAN UREUM SERUM TIKUS PUTIH GALUR WISTAR TERINDUKSI SISPLATIN ., Michael
Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN Vol 1, No 1 (2013): Jurnal S1 Prodi Farmasi FK UNTAN
Publisher : Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (595.045 KB)

Abstract

Cisplatin is a chemotherapy drug that had nephrotoxicity side effect which marked with the increase of urea and creatinine. Kesum (Polygonum minus Huds.) is one ofthe potential herbs that can be used to decrease urea and creatinine concentration. Thepurposes of this research is to find out the secondary metabolite contents of kesumleaves methanol extract and the activity of urea and creatinine concentrationreduction which rats were treated to have nephrotoxic with induction of cispatin.Kesum leaves extraction was done by maseration method using methanol solvent.Phytochemical screening test was perfomed with a tube to detect the compound inkesum leaves extract. The rats were divided into 5 groups which are non-treatedgroup (CMC1%), cisplatin control group, dose 1 group (8,664 mg/200 grBW), dose 2group (17,328 mg/200 grBW), and dose 3 group (34,656 mg/200 grBW). Theconcentration of urea and creatinine were checked at day 10 after the induction usespectrophotometer UV-Vis. Data were analyzed with Oney Way ANOVA and PostHoc Test Multiple Comparisons-Tukey HSD test. Phytocemistry screening showsthat kesum leaves methanol extract compound alkaloid, polyphenol, tannin,flavonoid, triterpenoid and saponin. The results show that dose 1, dose 2, and dose 3can decrease urea and creatinine concentration which indicate that it has potency toreduce the side effect of chemotherapy agent cisplatin.
RISIKO, PROFITABILITAS, PERTUMBUHAN ASET, DAN ASET TETAP TERHADAP KEBIJAKAN DIVIDEN DAN KEBIJAKAN UTANG ., Michael; Wijaya, Liliana Inggrit
Journal of Management and Business Vol 9, No 2 (2010): SEPTEMBER 2010
Publisher : Department of Management - Faculty of Business and Economics. Universitas Surabaya.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (320.78 KB) | DOI: 10.24123/jmb.v9i2.165

Abstract

The aim of this study is to analyze the factors that influence financing policy. Financing policy as the independent variable consist of dividend anddebt policies. The factors that influence the dividend policy are business risk, profitability, and growth. Debt policy influence by dividend, business risk,profitability, and fixed asset. Toestimate relation between these factors, this study used Seemingly Unrelated Regression (SUR) because the debt and dividend model have same error term. Research object are companies in manufacture industry that listing in Indonesian stock Exchange that paid dividend in minimum 4 periods in research periods. The result of the analysis indicates that profitability have a significant influence toward dividend policy. Result for debt policy are business risk, profitability, and fixed asset have a significant influence toward debt policy. The result also shows that profit has positive significant effect to dividend, which indicates the ability of the firm to pay higher dividend while their profit increased. Risk and profit also show positive effect to debt. Firms with higher profit will have higher debt, however their risk also increased in significant positive relationship.
Co-Authors Liliana Inggrit Wijaya