The prevalence of autism spectrum disorder (ASD) increases from year to year. This increase is linear with increasing problems in families with ASD, one of which is related to caring for the mother of a child with ASD, where the mother is considered the main caregiver and has a close relationship with the child. One of the factors that influences maternal care is religiosity. The aim of this study was to validate the religiosity scale in mothers of children with autism spectrum disorder. This research uses quantitative methods, with data collection in the form of distributing The Centrality of Religiosity Scale (CRS) to a sample of mothers of children with ASD, who are members of the PLA and Yamet communities in Central Java and Yogyakarta, totaling 220 subjects. Researchers carried out the process of adapting The Centrality of Religiosity Scale (CRS)(Huber & Huber, 2012),by translating it into Indonesian, adapting it to the characteristics of the subject, namely mothers of children with ASD, and adapting it to Indonesian culture. The scale validation test uses the 2nd Order CFA technique, and produces (1) a model fit test with fit criteria; (2) validity test, showing that all items are valid (a total of 15 items); (3) the reliability test shows that the five dimensions (of the CRS construct) are measured reliably. The reliability of the five CRS dimensions is classified as high based on the Composite Reliability (CR) and Average Variance Extracted (AVE) values. Apart from that, CRS also meets the convergent validity test. The results of the CRS scale model fit test met the model fit criteria, with a chi-square value = 160.00; GFI = 0.92; RMR = 0.03; RMSEA = 0.06; CFI = 0.99. It can be concluded that the results of the adaptation of The Centrality of Religiosity Scale (CRS-15 items;Huber & Huber, 2012)can be used for research because it meets the validity and reliability tests of the scale.