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All Journal Majalah Kesehatan Pharmamedika Junior Medical Journal
Syamsul Hadi, Restu
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Religion Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Mekanisme Apoptosis Pada Regresi Sel Luteal Syamsul Hadi, Restu
Majalah Kesehatan Pharmamedika Vol 3, No 1 (2011): JANUARI - JUNI 2011
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v3i1.442

Abstract

Corpus luteum is a transient endocrine gland and its presence plays pivotal role in ovulation process, implantation, and luteinization. The regression of corpus luteum or luteolysis is actually needed for next cycle survival and playing a role in providing new follicles.  Luteal regression represents a broad definition of the process of demise of the corpus luteum that is capable of accommodating all new knowledge evolved on the molecular mechanisms activated or inhibited during the process of regression of the corpus luteum. Apoptosis is controlled by a number of regulator genes such as bcl-2 family. The ratio of Bax expression to Bcl-2 is a pivotal factor for a cell to survive or apoptosis. The increasing Bcl-2 expression will lengthen cell life, whereas increasing of Bax expression promotes cell death.
Apoptosis Pada Sperma Sebagai Petanda Adanya Gangguan Kesuburan Pria Syamsul Hadi, Restu
Majalah Kesehatan Pharmamedika Vol 3, No 2 (2011): JULI - DESEMBER 2011
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/mkp.v3i2.449

Abstract

Semen analysis includes assessment of volume, color, viscosity, pH, concentration, motility, and morphology as standard procedures to semen analysis. It has known that correlation between apoptosis and spermatogenesis. Apoptosis is a mechanism regulating spermatogenesis in humans, and there are clear differences in molecular markers of apoptosis between males with normal sperm parameters and those with abnormal sperm parameters. Sperm apoptotic apoptosis has been shown to increase after testicular injury, such as exposure to toxics, varicocle, testicular torsion, hormonal deprivation and genetic abnormalities. It has been found that the number of sperm with Fas expression was low in subjects with normal sperm parameters but high in men with abnormal sperm parameters. It has been reported that the number sperm with Fas expression was low in subjects with normal sperm parameters but high in men with abnormal sperm parameters. Male infertility appears to be positively correlated with increased levels of apoptotic sperm. Sperm DNA damage and sperm apoptosis have been considered as useful marker of male fertility disorder.
Pengaruh Fermentasi Madu Terhadap Viabilitas dan Proliferasi Sel Fibroblast Pasca Diinduksi Cisplatin In Vitro Serta Tinjauan Menurut Islam Anwar, Alifah Fitria; Syamsul Hadi, Restu; Karimulloh
Junior Medical Journal Vol. 3 No. 1 (2024): September 2024
Publisher : Fakultas Kedokteran Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jmj.v3i1.4329

Abstract

Pendahuluan : Salah satu pengobatan kanker ialah dengan kemoterapi dan salah satu kemoterapi yang terkenal dan telah digunakan untuk berbagai pengobatan kanker ialah Cisplatin. Karena resistensi obat dan berbagai efek samping yang dapat terjadi, terapi kombinasi Cisplatin dengan obat lain harus dipertimbangkan untuk mengatasi resistensi obat dan mengurangi toksisitas. Metodologi : Jenis penelitian yang digunakan adalah penelitian eksperimental laboratorium dengan data yang akan diambil secara langsung dengan melakukan sebuah eksperimen/percobaan in vitro yang bertujuan mengerahui pengaruh fermentasi madu terhadap viabilitas dan proliferasi sel fibroblast pasca diinduksi cisplatin in vitro. Penelitian ini menngunakan 4 kelompok perlakuan dengan tiga kali pengulangan (triplicate) yang diberikan cisplatin dan fermentasi madu dengan konsentrasi 5% dan 10% dan diamati selama 24 jam. Analisis data yang akan digunakan ialah normalitas, one way ANOVA dan Uji Pos Hoc. Hasil : Fermentasi madu dapat memberikan efek pada viabilitas dan proliferasi sel fibroblast. Simpulan : penggunaan fermentasi madu untuk melihat pengaruhnya pada viabilitas dan proliferasi sel fibroblast pasca diinduksi cisplatin in vitro diperbolehkan karena sesuai dengan menjaga Al-Dharuriyat Al-Kham.
Co-Authors Anwar, Alifah Fitria Karimulloh, Karimulloh