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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Kesehatan Islam : Islamic Health Journal Journal Equity of Law and Governance
Marisca Evalina Gondokesumo
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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LEGALITY OF MARIJUANA USE IN THE NEED FOR MEDICAL TREATMENT IN INDONESIA (JUDGING FROM LAW NUMBER 36 OF 2009 CONCERNING HEALTH AND LAW NUMBER 35 OF 2009 CONCERNING NARCOTICS) Marisca Evalina Gondokesumo; Nabbilah Amir
Journal Equity of Law and Governance Vol. 1 No. 2
Publisher : Warmadewa Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (182.088 KB) | DOI: 10.55637/elg.1.2.3938.119-126

Abstract

Marijuana according to positive law in Indonesia including narcotics group I which is considered the most dangerous because it has a very high addiction and the plant has long been viewed negatively by the wider community, but behind the negative stigma of the community it turns out that marijuana contains many benefits for health care needs. The issue for legalizing cannabis for medical purposes was initiated by the Nusantara Marijuana Circle organization. This research aims to examine whether the use of marijuana for medical purposes in Indonesia has received legalization. The research method used is empirical juridical. The legal materials use are primary legal materials and secondary legal materials. The results showed that because the law was born and developed continuously to build and change itself towards a better level of perfection. With so much potential contained in cannabis, especially its presence in the health sector it is appropriate for state officials to revise policies on narcotics. Legalization of cannabis can be used as an alternative solution for the Indonesian state to improve the welfare of the community because it can be used as an alternative to the country's industrial commodities, especially in the field of health services.
SENYAWA FITOESTROGEN UNTUK POTENSI TERAPI PENYAKIT NEURODEGENERATIF TERHADAP RESEPTOR TLR2: PENDEKATAN IN SILICO Faisal Akhmal Muslikh; Rizki Rahmadi Pratama; Marisca Evalina Gondokesumo
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 12 No. 1 (2023): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v12i1.19860

Abstract

ABSTRAK Latar belakang: Toll-like receptor (TLRs) secara umum diekspresikan dalam sistem saraf pusat (SSP) dan memainkan peran penting dalam keberlangsungan hidup sel baik sel neuron, mikroglia, astrosit, dan oligodendrosit. TLR2 merupakan salah satu kelompok TLR yang banyak diteliti dan dikaitkan dengan penyakit neurodegenerative karena dapat menimbulkan kondisi pro-inflamasi dalam SSP. Senyawa fitoestrogen mampu menggantikan peran estrogen dalam menjaga homeostasis tubuh termasuk pada SSP. Penelitian ini bertujuan untuk mengetahui peran senyawa fitoestrogen dalam menghambat aktivasi TLR2 (6NIG) yang dapat menyebabkan penyakit neurodegenerative. Metode: Metode yang digunakan adalah molecular docking dengan AutoDockTools 1.5.6 program. Prediksi sifat farmakokinetik dan farmakodinamik dilakukan menggunakan SwissADME, sedangkan toksisitas menggunakan pkCSM dan ProTox II. Hasil dan Pembahasan: Hasil docking menggunakan protein 6NIG menunjukkan bahwa senyawa α-amyrin dan β-amyrin memiliki potensi terbaik dalam pengikatan dibandingkan dengan 17β-estradiol yang merupakan kontrol positif. Secara uji farmakokinetik dan farmakodinamik menunjukkan bahwa kedua senyawa tersebut memiliki permeabilitas yang baik, lipofilitas yang kuat sehingga mampu menembus membrane sel, dan tidak bersifat toksik. Kesimpulan: senyawa memiliki potensi untuk terapi penyakit neurodegenerative terhadap reseptor TLR2 (6NIG). Kata Kunci: ADMET; in silico; neurodegenerative; senyawa fitoestrogen; TLR2.
Formulation and characterization of dermal patch containing mangosteen (Garcinia mangostana L.) peel extract using ethyl cellulose and polyvinylpyrrolidone polymers Ni Luh Dewi Aryani; Rismawati; Marisca Evalina Gondokesumo
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.30375

Abstract

Mangosteen peel extract (Garcinia mangostana L.) shows strong potential in treating diabetic ulcers. Topical applications via dermal patches enable direct delivery of active compounds while protecting wounds from contaminants, preventing bacterial invasion, and maintaining moisture factors essential for promoting effective wound healing in diabetic patients. The dermal patches of mangosteen peel extract were developed using a combination of EC and PVP K-30 polymers. Previously, the mangosteen peels were extracted utilizing the ultrasound-assisted extraction method. Subsequently, the dermal patches were prepared utilizing solvent casting techniques, employing a combination of ethyl cellulose and polyvinyl pyrrolidone in ratios of 1:3 (F1), 1:2 (F2), and 1:1 (F3). The dermal patches were assessed for their physicochemical properties, including organoleptic characteristics, thickness, weight uniformity, folding endurance, moisture uptake, moisture loss, and pH values. The content of alpha-mangostin was analyzed using UV spectrophotometry, while the interactions between the active ingredient and excipients were examined through Fourier Transform Infrared Spectroscopy. The crystallinity profiles were analyzed using an X-ray diffractometer. Surface morphologies were assessed using scanning electron microscopy. The dermal patches were thin, light yellow, smelled of menthol, uniform in size, and exhibited good folding endurance (>300 folds). The moisture uptake and moisture loss were minimal. The pH values ranged from 6.99 to 7.24. The total xanthone concentrations in patches F1, F2, and F3 were 95.26% ± 0.47, 71.42% ± 1.99, and 78.54% ± 0.47, respectively. It showed no chemical interaction between active ingredients and excipients and had amorphous forms. The surface morphologies displayed smoothness for F1, whereas F2 and F3 exhibited solid spots. It was concluded that formulation F1, which contained ethyl cellulose and polyvinyl pyrrolidone in a 1:3 ratio, was the optimal formulation.
Co-Authors Faisal Akhmal Muslikh Nabbilah Amir Ni Luh Dewi Aryani Rismawati