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Mohamadpour, Farzaneh
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CrCl3·6H2OAs an Environmentally Friendly and Efficient Catalyst for One-Pot,Synthesis of 2-oxo-and 2-thio-1,2,3,4-Tetrahydropyrimidines Under Solvent-Free Conditions Mohamadpour, Farzaneh
Makara Journal of Science Vol. 22, No. 4
Publisher : UI Scholars Hub

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A one-pot, simple, and eco-friendly synthesis of 2-oxo-and 2-thio-1,2,3,4-tetrahydropyrimidines using a Biginelli condensation between β-keto esters (methyl or ethyl acetoacetate), aromatic benzaldehydes, and urea or thiourea in the presence of CrCl3·6H2O as an environmentally friendly and mild catalyst under solvent-free conditions has been performed. Based on reaction of benzaldehyde (1.0 mmol), ethyl acetoacetate (1.0 mmol), and urea (1.5 mmol), as well as 15 mol% of CrCl3·6H2O catalyst, the 82% yield was reached within 30 minute reaction time. The advantages of this methodology are solvent-free conditions, ease of handling, one-pot nature, low-cost, environmental friendliness, simple purification of products, and short reaction time.
Development of an Environment-Friendly and Solvent-Free Synthetic Route for the Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones/Thiones Using La(NO3)3.6H2O as an Efficient Catalyst Mohamadpour, Farzaneh
Makara Journal of Science Vol. 22, No. 3
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We present a facile and environmentally friendly procedure for the synthesis of corresponding 3,4-dihydropyrimidin-2-(1H)-ones/thiones derivatives. The synthesis was achieved using aone-pot three-component Biginelli reaction among β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehyde derivatives), and urea or thiourea in the presence of lanthanum (III) nitrate hexahydrate (La(NO3)3.6H2O), as a highly efficient catalyst under solvent-free conditions. This protocol has numerous advantages: it isan inexpensive, non-toxic, simple reaction work-upcatalyst with a high atom-economy, and shows excellent yields with short reaction times.
ZnSO4.7H2O Catalyzed One-pot and Facile Synthesis of Highly Substituted Dihydro-2-oxopyrroles at Room Temperature Mohamadpour, Farzaneh
Makara Journal of Science Vol. 22, No. 2
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A mild and facile ZnSO4.7H2O-catalyzed procedure is developed for the convenient one-pot synthesis of highly substituted dihydro-2-oxopyrroles under mild reaction conditions. In this procedure, dihydro-2-oxopyrroles are synthesized via the four-component reactions of amines, dialkyl acetylenedicarboxylates and formaldehyde. The present procedure is an economical and mild approach that offers numerous advantages, including good to high yields, simplicity, inexpensive and readily available catalyst, and high atom economy.
Eco-friendly and Convenient Synthesis of Biologically Active Polysubstituted Dihydro-2-Oxypyrroles Using Manganese (II) Nitrate Tetrahydrate at Ambient Temperatures Mohamadpour, Farzaneh
Makara Journal of Science Vol. 23, No. 1
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A convenient, expedient and efficient method for the synthesis of polysubstituted dihydro-2-oxypyrroles is described via the one-pot four-condensation of dialkyl acetylenedicarboxylate, formaldehyde, and amines (aromatic and aliphatic) at ambient temperature in the presence of Manganese (II) Nitrate Tetrahydrate (Mn(NO3)2.4H2O) as a cost effective and inexpensive catalyst. The present methodology provides a simple and eco-safe procedure for the synthesis of polysubstituted dihydro-2-oxypyrroles with some additional advantages, such as good to high yields, short reaction times, avoidance of hazardous or toxic catalysts, simplicity of operating and work-up procedures with no necessity for chromatographic purification steps.
Malonic Acid as A Green and Efficient Catalyst for the Mass-scale Synthesis of Pyrrole Medicinal Drugs Mohamadpour, Farzaneh
Makara Journal of Science Vol. 24, No. 3
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A green and naturally biodegradable malonic acid synthesis of highly substituted dihydro-2-oxopyrrole derivatives has been accomplished via one-pot four-condensation of amines (aromatic or aliphatic), dialkyl acetylenedicarboxylate, and formaldehyde under mild reaction conditions. The notable advantages of the present procedure are a green, low cost, and efficient catalyst; operational simplicity; no need for chromatographic purification steps; short reaction times; and good to high yields.
Efficient and Mild Four-component Process for the Synthesis of Highly Substituted Dihydro-2-oxopyrroles using ZrOCl2∙8H2O as an Environmental-ly Friendly Catalyst Mohamadpour, Farzaneh
Makara Journal of Science Vol. 24, No. 4
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This study investigated the catalytic ability of ZrOCl2∙8H2O as a mild, environmentally benign nature, and economical catalyst for the multi-component efficient synthesis of biologically active highly substituted dihydro-2-oxopyrrole derivatives with excellent yields and short reaction times. This procedure has several advantages, including use of mild, nontoxic, and inexpensive catalysts, one-pot synthesis, environmentally benign nature, simple operational procedure, and highly efficient conditions.
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