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Wiraguna AAGP
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Pemberian Krim Ekstrak Daun Sukun (Artocarpus altilis )Mencegah Peningkatan Jumlah Melanin Kulit Marmut (Cavia porcellus )yang Dipapar Sinar Ultraviolet B (UVB ) Riliani, Marisa; Pangkahila, Wimpie; AAGP, Wiraguna
Majalah Kesehatan Pharmamedika Vol 9, No 2 (2017): DESEMBER 2017
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1531.869 KB) | DOI: 10.33476/mkp.v9i2.678

Abstract

Skin is the main target of ultraviolet (UV) ray that result the abnormality of hiperpigmentation. In pathology, hyperpigmentation is caused by an increasing in the amount of melanin. The purpose of this research was to prove the effect of administration of breadfruit leaves extract (Artocarpus altilis) cream prevented the increase of skin melanin in guinea pig (Cavia procellus) exposed to ultraviolet B and to prove the administration of breadfruit leaves extract (Artocarpus altilis) cream have the same effectiveness with 4% hydroquinone cream in preventing the increase of skin melanin in guinea pig (Cavia procellus) exposed to ultraviolet B. This study was a true experimental research using post test only control group design. The subjects were devided into three groups. Group 1 as a control group was treated by UVB exposure and basic cream. Group 2 was treated by UVB and 4% hydroquinone cream. Group 3 was treated by UVB and 3% breadfruit leaves extract cream. There was significant difference within control group compared with group 2 and 3 (p0,05). There was no significant difference within group 2 compared with group 3 (p0,05).The administration of 3% breadfruit leaves extract (Artocarpus altilis) cream prevented the increase of skin melanin in guinea pig (Cavia procellus) exposed to ultraviolet B. The administration of 3% breadfruit leaves extract (Artocarpus altilis) cream had the same effectiveness with 4% hydroquinone cream.
LAMELLAR ICHTHYOSIS (COLLODION BABY) IGE, Paramarta; W, Retayasa; M, Kardana; AAGP, Wiraguna; S., Herman
Medicina Vol 39 No 1 (2008): Januari 2008
Publisher : Medicina

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Abstract

The ichthyosis are a heterogeneous group of hereditary and acquired disorder of keratinization which affected the epidermis characterized by presence of visible scales on the skin surface in the absence of inflammation. It can occur as a disease limited to the skin or in association with abnormalities of other organ systems. Lamelar ihthyosis (LI) is one of two mayor autosomal recessive ichthyosis with an incidence of approximately one in 300,000. The diagnosis is based on clinical and pathologic finding. Infection is the most common complication, while prognosis of LI is depends on severity and complication of the disease. A case of lamellar ichthyosis in 0 day Balinese female baby was reported. The skin of the body was thick, plate-like appearance, scaling on the entire body, some of the thick skin was ruptured on chest and extremities. There were eclabium on the mouth and ectropion on the eyes. Histopathology examination showed hyperkeratosis without perivascular infiltration lymphocyte. The baby was given breast feeding, antibiotic, hydrocortisone cream and olium olivarum. The prognosis of the baby is good.
Co-Authors Herman S. Kardana M Paramarta IGE Retayasa W Riliani, Marisa Wimpie I Pangkahila