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All Journal International Journal of Public Health Science (IJPHS) Borneo Journal of Pharmacy
Muhindo, Abraham Bwalhuma
Unknown Affiliation
Health Professions Medicine & Pharmacology

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A Review of Antifungal Resistance in West Africa Muhindo, Abraham Bwalhuma; Aliero, Adamu Almustapha; Syalhasha, Festo Mwebaze; Ntulume, Ibrahim; Eilu, Emmanuel; Odoki, Martin; Mutebi, Joe
Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i2.6507

Abstract

Knowledge of local and regional antimicrobial resistance (AMR) is important for clinical decision-making. However, surveillance capacity for fungal infections let alone antifungal resistance is lacking throughout West Africa, and current antifungal resistance data are sparse. We sought to address this gap by summarizing all available high-quality data on antifungal resistance in West Africa. We searched the PubMed database, African Journals Online archives, and free web searches in October and December 2023 using the terms "antifungal resistance" and "West Africa" to find articles published from 2010 onwards. Only 11 articles were included in our analysis most of which were cross-sectional and descriptive in design; relatively high levels of antifungal resistance (AFR) to commonly used antifungals were reported including (24-75%) resistance to fluconazole and ketoconazole, two of the most frequently-prescribed antifungals in this region. There is a high level of resistance to griseofulvin, ketoconazole, cotrimoxazole, and fluconazole among dermatophyte infections (80-100%) with 100% resistance to amphotericin B, ketoconazole, and fluconazole reported by the invasive fungal disease-causing pathogen Cryptococcus neoformans. Resistance to commonly used anti-fungal drugs is prevalent; raising concern that these drugs may no longer be useful for treating moderate or severe fungal infections in West Africa hence calling for countries to promote acceptance of antimicrobial stewardship as a programmatic strategy not just focused on bacterial resistance but also fungal resistance including pharmacy management, laboratory complete mycological investigations and dissemination of standard fungal susceptibility profiles.
Antimicrobial resistance profiles of methicillin resistant coagulase negative Staphylococcus at a reference laboratory in Sierra Leone: implications for infection control Muhindo, Abraham Bwalhuma; Aliero, Adamu Almustapha; Jiba, Darlinda F.; Syalhasha, Festo Mwebaze
International Journal of Public Health Science (IJPHS) Vol 14, No 4: December 2025
Publisher : Intelektual Pustaka Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijphs.v14i4.26835

Abstract

Methicillin-resistant CoNS (MR-CoNS) are increasingly recognized as significant nosocomial pathogens. Sierra Leone lacks data on the prevalence and antibiotic-resistance patterns of these bacteria, which hinders a cross-sectoral approach to tackling antimicrobial resistance as well as regional and global health surveillance. We report on clinical multidrug-resistant MR-CoNS from Freetown, Sierra Leone, West Africa, as emerging pathogens. This study aimed to explore the prevalence and antimicrobial resistance profiles of MR-CoNS isolated from clinical samples in Freetown, Sierra Leone. A cross-sectional study was conducted at the reference laboratory from January 2025 to June 2025. Clinical samples submitted to the microbiology department were screened for Staphylococcus species, and isolates identified as coagulase-negative Staphylococci (CoNS) using standard microbiological techniques. Methicillin resistance in all isolates was tested with a 30 μg cefoxitin disc and further confirmed through an automated Scenker XK Microbial ID and AST system by measuring the minimum inhibitory concentration (MIC) with oxacillin. Antibiotic susceptibility profiles were determined using the Scenker XK Microbial ID/AST system following the Clinical and Laboratory Standards Institute (CLSI) guidelines, and data were analysed using SPSS ver 16. Findings from our study show a prevalence of 18.2% of MR-CoNS with Staphylococcus schleiferi, (26.9%) predominant. Linezolid, vancomycin, and teicoplanin exhibited 100% activity against all the MR-CoNS isolated. However, there was co-and multidrug resistance exhibited to commonly known antibiotics gentamycin (75-100%), levofloxacin (80-100%), clarithromycin (87-100%), including resistance to newer antibiotics as daptomycin (33-50%).
Co-Authors Aliero, Adamu Almustapha Eilu, Emmanuel Jiba, Darlinda F. Mutebi, Joe Ntulume, Ibrahim Odoki, Martin Syalhasha, Festo Mwebaze