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Ahmad Ghozali Ahmad Ghozali
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Nucleolar organizer region (AgNOR) staining on fibrocystic change of the breast. Ahmad Ghozali, Ahmad Ghozali
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 02 (1997)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.478 KB)

Abstract

In the past the fibrocystic change of breast was considered as a precancerous lesion, consequently the management of a fibrocystic patient was often overdone. Later, after thorough researches, it has been histologically (Page classification) proven that only small part of the changes have high risk to become invasive carcinoma. The leading factor which increases the risk is the grade of proliferation of the gland epithelia. AgNOR stain is a staining method to evaluate cell proliferation activity which has been proven as one of tools for the assessment of the prognosis of several malignant tumors including breast cancer. in this study the amount of AgNOR in fibrocystic change was studied based on Page classification. Nineteen fibrocystic cases classified by Page were stained with colloidal silver. NORs were counted manually. The mean of AgNOR of each classification, normal gland, and carcinoma was compared. There were significant differences of AgNOR count found between each classification, normal gland and carcinoma. The AgNOR count of non proliferative lesion were 2.074 ± 0.320, proliferative disease without atypia 2.416 ± 0.35, atypical hyperplasia 2.876 ± 0.249, normal gland 1.637 ± 0.330, and in carcinoma 4.407 ± 0.340. The result demonstrated that the AgNOR staining is a reliable marker for proliferation activity, and can differentiate atypical hyperplasia from carcinoma. The determination of AgNOR count can be done routinely to follow up and monitor the high risk lesions.Key words: fibrocystic change - Page classification - nucleolar organizer.
Breast fibrocystic change and Pages classification Ahmad Ghozali, Ahmad Ghozali
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 01 (1994)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.487 KB)

Abstract

Fibrocystic change is a benign breast lesion commonly found in women. In the past this lesion was regarded as having a high potential malignancy. By using Pages classification, Dupont and Page histologically proof that most of fibrocystic lesions (69,7%) have equal risk for malignancy with normal women population. Only 4% of the benign breast lesion have high risk to become breast carcinoma.The study of Dupont and Page has changed the terminology and point of view regarding malignant potency of the fibrocystic lesion of the breast. In the future pathologists are recommended to apply Pages classification in order to treat the patient with fibrocystic lesion more properly.Key words: fibrocystic change-carcinoma in situ of the breast-Pages classification-a typical hyperplasia-breast cancer
Cytologic examination of the thoracocenthesis fluid for the diagnosis of a malignant mesothelioma and adenocarcinoma. A comparative diagnosis. Ahmad Ghozali, Ahmad Ghozali
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 03 (1993)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (135.735 KB)

Abstract

Reccurent pleural effusions are frequently the first manifestation of a diffuse malignant pleural mesothelioma. Pleural effusion of the malignant mesothelioma is frequently indistinguishable from the pleural effusion due to adenocarcinoma. The prognosis of this tumor is poor, but immediate and accurate therapy will render prolonged remission. For these reasons, microscopic examination of thoracocenthesis fluid is necessary, because it may provide an immediate diagnosis.Unfortunately, the reliability of cytologic diagnosis is still disputable. Based on microscopic examination, there is no single pathognomonic feature. The cytologic diagnosis of a malignant pleural examination is based on the constellation of findings. The history of the course of the disease, optimal sample preparation, and special stains are important requirements to provide definitive diagnosis.Key Words: mesothelioma adenocarcinoma thoracocenthesis fluid air-dried May Grunwald - Giemsa monoclonal antibody B72.3
Nucleolar organizer region (AgNOR) staining on fibrocystic change of the breast. Ahmad Ghozali Ahmad Ghozali
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 02 (1997)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.478 KB)

Abstract

In the past the fibrocystic change of breast was considered as a precancerous lesion, consequently the management of a fibrocystic patient was often overdone. Later, after thorough researches, it has been histologically (Page classification) proven that only small part of the changes have high risk to become invasive carcinoma. The leading factor which increases the risk is the grade of proliferation of the gland epithelia. AgNOR stain is a staining method to evaluate cell proliferation activity which has been proven as one of tools for the assessment of the prognosis of several malignant tumors including breast cancer. in this study the amount of AgNOR in fibrocystic change was studied based on Page classification. Nineteen fibrocystic cases classified by Page were stained with colloidal silver. NORs were counted manually. The mean of AgNOR of each classification, normal gland, and carcinoma was compared. There were significant differences of AgNOR count found between each classification, normal gland and carcinoma. The AgNOR count of non proliferative lesion were 2.074 ± 0.320, proliferative disease without atypia 2.416 ± 0.35, atypical hyperplasia 2.876 ± 0.249, normal gland 1.637 ± 0.330, and in carcinoma 4.407 ± 0.340. The result demonstrated that the AgNOR staining is a reliable marker for proliferation activity, and can differentiate atypical hyperplasia from carcinoma. The determination of AgNOR count can be done routinely to follow up and monitor the high risk lesions.Key words: fibrocystic change - Page classification - nucleolar organizer.
Breast fibrocystic change and Page's classification Ahmad Ghozali Ahmad Ghozali
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 01 (1994)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.487 KB)

Abstract

Fibrocystic change is a benign breast lesion commonly found in women. In the past this lesion was regarded as having a high potential malignancy. By using Page's classification, Dupont and Page histologically proof that most of fibrocystic lesions (69,7%) have equal risk for malignancy with normal women population. Only 4% of the benign breast lesion have high risk to become breast carcinoma.The study of Dupont and Page has changed the terminology and point of view regarding malignant potency of the fibrocystic lesion of the breast. In the future pathologists are recommended to apply Page's classification in order to treat the patient with fibrocystic lesion more properly.Key words: fibrocystic change-carcinoma in situ of the breast-Page's classification-a typical hyperplasia-breast cancer
Cytologic examination of the thoracocenthesis fluid for the diagnosis of a malignant mesothelioma and adenocarcinoma. A comparative diagnosis. Ahmad Ghozali Ahmad Ghozali
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 03 (1993)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (135.735 KB)

Abstract

Reccurent pleural effusions are frequently the first manifestation of a diffuse malignant pleural mesothelioma. Pleural effusion of the malignant mesothelioma is frequently indistinguishable from the pleural effusion due to adenocarcinoma. The prognosis of this tumor is poor, but immediate and accurate therapy will render prolonged remission. For these reasons, microscopic examination of thoracocenthesis fluid is necessary, because it may provide an immediate diagnosis.Unfortunately, the reliability of cytologic diagnosis is still disputable. Based on microscopic examination, there is no single pathognomonic feature. The cytologic diagnosis of a malignant pleural examination is based on the constellation of findings. The history of the course of the disease, optimal sample preparation, and special stains are important requirements to provide definitive diagnosis.Key Words: mesothelioma adenocarcinoma thoracocenthesis fluid air-dried May Grunwald - Giemsa monoclonal antibody B72.3
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