Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Ahmad H. Asdie Ahmad H. Asdie
Unknown Affiliation
Immunology & microbiology Neuroscience

Published : 30 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 30 Documents
Search

 1   2   3 
The management of hyperlipidemia Ahmad H. Asdie, Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 23, No 03 (1991)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (410.676 KB)

Abstract

In terest in hyperlipidemia is related to its role in atherogenesis. The connection between bloodcholesterollevels and varibus manifestations of coronary heart disease has long been apparent.However, proof that this connecton is causal has been more elusive. For particular subpopulations it has been demonstrated that lowering elevated cholesterol levels can lead to fewer coronary heart disease events; this provides strong evidence of a causal relationship which can furthermore be favourably influenced.The significant lipid element contributing of plaque formation appears to be low density lipoprotein cholesterol, but its derivation in plaques in quite complicated. Low density lipoprotein and possibly intermediate density lipoprotein, with a somewhat lower cholesterol content, are known to enter sub-in finial spaces directly and they may do so in association whit cellular migration. Locally produced endothelial-derived relaxing factor.Despite the massive study on the subject of lipids, atherogenesis and its complications, much of our therapeutic endeavour still relates to hypothesis rather than established facts based on observations in humans. Key Words: hyperlipidemia - lipoproteins diet - physical exercise - antilipidemic drugs
Association ofIgpertension with diabetes mellitus Ahmad H. Asdie, Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 24, No 01 (1992)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.971 KB)

Abstract

The clinical impression of association between hypertension and diabetes mellitus has not been consistently confirmed by epidemiological studies. The variety of methodological problems in this area of research includes the choice of appropriate patients and control group, the measurement techniques used, and consideration of many possible confounding variables.Hypertension in diabetes mellitus patients contributes substantially to the increased cardiovascular morbidity and mortality, and should be actively treated as accurately as diabetes mellitus itself. The first therapeuticstep is reduction of overweight, saltintake, and stopsmoking; the omission of interfering drugs and adequate education. Prescription of diuretic drugs or alternatively of calcium antagonists, vasodilators of hydralazin or prazosin. The adds of minoxidil or cap topril to the previousdrugsshouldonlybe taken after evaluation of the overall situation. It should be kept in mind that all anti-hypertensive agents have disadvantages, some of them serious, when used for diabetic patients Key Words: diabetes mellitus - hypertension - cardiovascular mortality - anti-hypertensive treatment - overweight
Dengue Hemorrhagic Fever in adolescents and young adults in the Department of Internal Medicine, Gadjah Mada Ahmad H. Asdie, Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 5, No 02 (1973)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.152 KB)

Abstract

A short history of Dengue, the etiology of Dengue Hemorrhagic Fever and the vectors are reviewed. A classification and nomenclature for diseases suspected to be of dengue or chikungunya virus etiology, as suggested by WHO is given.Six cases and two additional cases of Dengue Hemorrhagic Fever in adolescents and young adults are reported.The bone marrow findings in our cases compared with those found in the literature.The pathogenesis of Dengue Hemmorrhagic Fever is reviewed in short.
The genetics of diabetes mellitus Ahmad H. Asdie, Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 22, No 02 (1990)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (409.758 KB)

Abstract

It is now clear that diabetes mellitus is not a disease in classical sense but is a genetically heterogeneous group of disorders which share glucose intolerance in common. Genetic heterogeneity, the concept that diabetes can have many different causes, was first suggested by the existence of rare genetic syndromes with diabetes, ethnic differences of clinical features, and genetic heterogeneity in animal models.This paper describes the background for genetic heterogeneity of diabetes mellitus which has major implications for the research and care of diabetic patients since the precise etiology, risk of complications and genetic counselling are likely to vary among these different disorder that result in diabetes.Key Words: diabetes mellitus - genetic heterogeneity - mode of inheritance - genetic counselling - antoinunune process
Management of myocardial infarction and the post-infarction patient Ahmad H. Asdie, Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 24, No 02 (1992)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.359 KB)

Abstract

Acute myocardial infarction is the most common form of premature death in the industrial world. Its early recognition and active intervention are becoming important in the light of recent advances, particularly the use of streptokinase shortly after the onset of the infarct. Cardiopulmonary resuscitation (CPR) is important both inside and outside the hospital. General practitioners should be confident in performing both basic life support and advanced cardiac life support since the potential needs for resuscitation is becoming great.In semi-rural areas where the general practitioner is usually the first to be called for assistance, the use of advanced resuscitation and life support does save lives. The defibrillator is an essential piece of equipment for monitoring, diagnosis, management and treatment in these cases.Following myocardial infarction the family physician has a major role to play in rehabilitation and tertiary prevention by prescribing beta-blockers, starting within two weeks of the infarct.Key Words: myocardial infarction - premature death - CPR - streptokinase - defibrillator
Diabetes Mellitus dan Sulfonilurea Ahmad H. Asdie, Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 21, No 01 (1989)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (527.96 KB)

Abstract

Diabetes mellitus characterized by increased blood glucose level (hyperglycemia) is currently recognized to be a heterogenous disorder. Although there has been general acceptance of the classification adopted by WHO Expert Committee on Diabetes Mellitus in 1980, the WHO Study Group revised the classification in 1985. The most important change from the previous classification is the appearance of malnutrition-related diabetes mellitus as a major subclass, ranking with IDDM (insulin-dependent diabetes mellitus) or type I diabetes mellitus and NIDDM (non-insulin- dependent diabetes mellitus) or type II diabetes mellitus.Sulfonylurea orally administered hypoglycemic agents have been used in the treatment of NIDDM for more than 30 years. Despite this fact, the mechanism responsible for hypoglycemic action of sulfonylurea agents remains controversial. Sulfonylureas are now generally thought to act by improving both the ability of pancreatic islets to secrete insulin and the response of tissues to insulin. There are two kinds of sulfonylureas, so-called first•generation sulfonylureas (tolbutamide and chlorpropamide) and second-generation sulfonylureas (glybenclamide, glyclazide, glypizide, and glyquidone), now available in Indonesia. The indications, contraindications, and guidelines for the use of these agents, as well as their mechanisms of action and the differences among them, are reviewed in this article.Key Words: classification of diabetes mellitus - sulfonylureas - hyperglycemia - malnutrition -- insulin
The Role of Lipids in Atherogenesis Ahmad H. Asdie, Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 26, No 02 (1994)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.991 KB)

Abstract

Hiperkolesterolemia, hipertensi, diabetes dan merokok telah lama diakui sebagai faktor risiko utama penyakit jantung koroner. Komponen utama bercak aterosklerotik adalah timbunan lipid, terutama ester kolesterol dan kolesterol, proliferasi dan perubahan sel otot polos intima arteri. Timbunan lipid dalam intima arteri terutama berasal dari low-density lipoprotein (LDL) yang telah termodifikasi dalam darah. Hal ini terjadi sebelum proliferasi otot polos intima timbul. Walaupun hubungan kausal antara hiperkolesterolemia dan penyakit jantung koroner sudah lama diterima para pakar, namun mengenai peran trigliserida dan jenis lipoprotein lainnya (high density lipoprotein, HDL) masih belum didapatkan kesepakatan. Dalam makalah ini dibahas pecan lipid dalam proses aterogenesis.Disimpulkan bahwa kelainan lipid yang berupa peninggian kolesterol (dan LDL) dan trigliserida (VLDL, terutama VLDL-sisa), dan.penurunan HDL merupakan faktor risiko bebas aterogenesis. Faktor hormonal ikut berperan dalam proses aterogenesis, dan diduga melalui efek hormon terhadap metabolisme lipid.Key Words : atherosclerosis - lipid - lipoprotein - apolipoprotein - coronary heart disease
Insulin receptor and insulin resistance in type -2 diabetes Ahmad H. Asdie, Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 24, No 02 (1992)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (206.181 KB)

Abstract

Resistance to the glucoregulatory effects of insulin is well-documented in type -2, non-insulindependent diabetes. Two separate factors may contribute in the pathogenesis, namely the obesity-related and the non-obesity-related.Obesity-related insulin resistance is associated with hyperinsulinemia, reduced numbers of insulin receptors on target cells. The mechanism by which the insulin receptor number is decreaSed is not clearly understood. This phenomenon is called "down regulation". If the defect in glucose transport can not be overcome at any insulin concentration, insulin unresponsiveness is present. This is caused by unidentified abnormalities distal to the receptor, "postreceptor defect".In non-obesity-related, a-cell dysfunction, secretion of abnormal insulin, failure to convert proinsulin to insulin, or hormonal antagonist to insulin, is thought to be responsible for the resistance.Key Words: type -2 diabetes mellitus - insulin receptor - insulin resistance - insulin antagonist - obesity-related and non-obesity-related factors
Diagnosis dan Kelasifikasi Diabetes Mellitus Ahmad H. Asdie, Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 20, No 02 (1988)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (324.994 KB)

Abstract

This paper presented the main recommendations for the definition and classification.of diabetes mellitus and of impaired glucose intolerance in non-pregnant adults.Diabetes mellitus is not a disease in the classical sense but is more probably a syndrome best characterized as a state of chronic hyperglycemia of various etiology. It may present with acute symptoms that include polyuria, polydipsia and unexplained weight loss and these can progress to life threatening ketoacidosis or hyperosmolar coma. Chronic hyperglycemia may be asymptomatic, but it has long been recognized as a predisposing factor for specific microvascular complications, namely neuropathy, retinopathy and nephropachy.Blood glucose concentration is the most common, variable used to define diabetes mellitus, but the increased blood glucose is not the sole pathological manifestation, nor has it been proved beyond doubt to be first in the pathological sequence. The limit between physiological and pathological values of blood glucose concentration is still debatable. An area of particular difficulty is the evaluation of situation that are near the physiological limit.New criteria for the diagnosis of diabetes mellitus and other catagories of glucose intolerance have been developed by National Diabetes Data Group (1979) and these have been endorsed by World Health Organization in 1980 and revised in 1985.Key Words: diabetes mellitus — target screening — chronic hyperglycemia — glucose intolerance -- hyperosmolar coma
Hypothyroidism in patient with Graves disease treated with antithyroid agent: A case report Ahmad H. Asdie, Ahmad H. Asdie
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 25, No 02 (1993)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (100.852 KB)

Abstract

The paper presented a case of hypothyroidism in patient with Graves disease after have long been treated with antithyroid agent. The cause of hypothyroidism in this case might be (1) the effect of anti-thyroid agent, (2) natural history of Graves disease as a result of autoimmune mechanism, and (3) coincidental presentation of Graves disease and condition causes hypothyroidism (hashitoxicosis).A 39 year old woman, household , admitted to Sardjito Hospital because of general fatigue and facial edema. She was previously treated as Graves disease with PTU (propylthiouracil) 100 mg 3 times 100 mg/day for 2 years. Because of allergic reaction against PTU, the drug was replaced by Neomercazol®. One year later the patient complaining body weight (BW) gain, with the laboratory investigation showed T3 = 0.78 µg/d1 (N: 0.6-1.9); T4 = 2436 µg/d1 (N: 45-100). Six months before admission she has not taken any drugs. On admission, BW 60 kg, other vital signs were in normal limits, palpebral edema, T3 = 0.3 itg/d1; Ta = 2.0 jig/d1; Total cholesterol 329 mg/dl; LDL-cholesterol 238 mg/dl; triglycerides 298 mg/d1; Anti-thyroglobulin 1/1280 (N: negative); anti-microsomal negative; other laboratory results revealed normal values. She was diagnosed as hypothyroidism post treatment of Graves disease. She was treated with Thyrax® 1 tablet daily, and one year later she was in a normal condition.All patients with Graves disease should be followed up regularly eventhough the clinical condition already subsided, since other autoimmune disease may coincidentally present.Key Words: hypothyroidism Graves disease hashitoxicosis antithyroid agents autoimmune disease
Co-Authors